Science Quiz / GU MNE Lectures 16 and 17

Random Science Quiz

Can you name the GU MNE Lectures 16 and 17?

Quiz not verified by Sporcle

Forced Order
Score 0/89 Timer 20:00
Mammals also employ: Activated choline condenses with _______ to form PC.
CDP-diacylglycerol + Serine =
Phosphatidylglycerol is a _______ backbone, __ _____ _____, and a glycerol head group - made through strategy __ using activated ___________
Sphingolipid defects are ________ early in embryonic development
Mammals synthesize PS via a ______ _______ with PE or PC
______ ______ ______ promotes aggregation of platelets and the release of the vasoconstrictor, serotonin, from platelets
Platelet activating factor also plays an important role in _________ and the allergic response in a variety of tissues.
Some of the _______ _________ are found on the surface of red blood cells and participate in giving them blood-group specificity.
diacylglycerol + ________ =
participate in the cell surface structures associated with blood types
Sphingolipids: Step 2: Attachment of a _____ _____ via an amide bond
Synthesis of plasmalogens: Occurs in two steps: (i) _________, and (ii) addition of ethanolamine from ____-ethanolamine
Galactocerebrosides are an end product but they can be modified by energy activated ________ which adds ______ group
Glycerophospholipid Biosynthesis (iv) (sometimes) alteration or exchange of the __________ to yield the final phospholipid product.
Sphingomyelin has an attachment of ____________
For Tay Sach's diagnosis, use analog of ganglioside that _______ breaks down, and look for fluorescent break-down product
Tay-Sachs disease is a defect in the enzyme ___________ ___
G = _________ and __= 1 SA, ___= 2 SA, ___ = 3 SA, __= 4 SA
Triacylglycerol Synthesis: Using phosphatidic phosphatase to remove a phosphate you get ___________________
______ ______ diseases result from defects of the lysosomal hydrolases, which results in accumulation of the hydrolases’ _______ substrates in the lysosome.
Use energy activated Diacylglycerol (activated with ______) to react with the _____ of a head group
Ataxia, Dystonia, Hypotonia are symptoms of ____ ____ diseases
Plasmalogens are abundant in the membranes of _______ ______ tissue, as well as many single cell organisms
The amino group of sphingosine can form an amide bond with the carboxylic group of fatty acids, yielding ________
In healthy people, the largest quantity of galactocerebroside is found in the _____
DPPC = 2 ______ ______ attached to ________
_________ is the only membrane phospholipid not derived from glycerol.
Glycerol-3-phosphate then has two ____ ____ ____ chains attached to form ______ ______
anionic phospholipids
Bacteria employ the strategy that uses _____-__________ for synthesis
_______ has a long hydrocarbon tail and a polar region that includes an amino group
with the addition of the sulfate, the monosaccharide has a _______ charge, so sulfatides are not neutral sphingoglycolipid
Acidic glycosphingolipids, also known as ________ contain one or more residues of______ ______
Impaired ________ of sphingolipids results in accumulation of membrane lipids
For ganglioside nomenclature: # = __ - moieties (But do NOT count ___)
________ is used
___________ (from C__)inactivates Platelet activating factor
an ester linkage is formed when a _____ group reacts with a _____ _____ in a ______ reaction, which liberates a water molecule
Phospholipids are derived form either ______, a three-carbon alcohol, or ________, a more complex amino-alcohol.
____________ are synthesized from different pathway and building blocks than ESTER-linked phospholipids
A cereamide attached to a Gal and a Glc is called a ________ _________
________ is used to make Glycerol-3-phosphate in kidneys and liver via the enzyme _______ ________
________-__-________ is a precursor for triacylglycerols and glycerophospholipids
alveoli needs surfactant (________) to reduce surface tension
Synthesis of Eukaryotic phospholipids uses _____-__________
Glycerophospholipid Biosynthesis (i) synthesis of the ________ molecule
Ganglioside ___ is the receptor for ______ toxin in the human intestine
__________ is a precursor to all other sphingolipids
__________ is a common lipid in brain, often referred to as “cerebroside”
_______ phospholipids are glycerophospholipids in which the fatty acid at position ___ of glycerol is attached with an ether linkage
Diagnosis of a given sphingolipidosis can be made from a _____ of the involved organ, usually bone marrow, liver, or brain, often looking for morphological changes associated with
The ________ are paracrine hormones derived from polyunsaturated 20-carbon fatty acids, predominantly ________ acid
The phosphate group of phosphatidic acid becomes esterified to the hydroxyl group of
Cardiolipin (high levels in Cardiac tissues) is a combination of 2 ______________
A glycerophospholipid consists of a glycerol backbone, two fatty acid chains, and a ________ ________
PC and PE are both synthesized using energy activated _________
____ is low when premature baby is born so they lack surfactant
Synthesis occurs in the Golgi, unlike ceramide and other phospholipids
most often in glycolipid storage diseases the biosynthetic rate remains normal, but a mutation exists in a structural gene for a _______
Platelet activating factor is a 1-_____-2-_____ ether analog of phosphatidylcholine.
the sugar moieties galactose (Gal), galactosamine (GalNAc), and Nacetylneuraminic acid (NANA), which are donated by ____-galactose, UDP-galactosamine, and _____-N-acetylneuraminic
Mammals synthesize ________ via a headgroup exchange with PE (or PC) NOT from directly from CDP-diacylglycerol, and ________ of PE only occurs in the liver
The synthesis of plasmalogens and other ether-linked phospholipids occurs via _________
simplest of neutral sugars are _________, which contain only ONE sugar residue, either ______ or _______
simplest glycerophospholipid (2 FA ,1 phosphate) is called _________ _______ or __________ __ -__________
Most common lipid storage disease is ________ disease, which cannot remove ________ to make _______
______ gets added to phosphatidic acid to form CDP-diacylglycerol
A _______ is a type of glycosphingolipid with more than one sugar as the side chain
PAPS is transferring Sulfate almost exclusively to the ____ of galactose.
The first steps of glycerophospholipid biosynthesis are shared with the pathway for the synthesis of ___________
_______ leads to diversity in gangliosides
Glycerophospholipid Biosynthesis (ii) attachment of ______ ______ to the backbone in ______ or _____ linkages
Sulfatide biosynthesis utilizes _____ as the source for an activated sulfate group
Glycerophospholipid Biosynthesis (iii) addition of a ______ ______ group joined to the backbone molecule via a ______ bond
Use energy activated head group (activated with ______) to react with OH of ___________
Sphingolipids: Step 3: ________of the alkane chain of acylsphinganine (results in ________)
Sphingolipids: Step 1: Synthesis of ________, an 18 carbon amino alcohol
In bacteria, phospholipid biosynthesis occurs at the plasma membrane; in eukaryotic cells, it occurs primarily at the surface of the ______ _____
One other class of acidic glycosphingolipids are the sulfatides, also known as _______
________ is used to make Glycerol-3-phosphate in ALL tissues
In glycerophospholipids, the hydroxyl groups at ____ and ____ of glycerol are esterified to the carboxyl groups of two ____ ____ chains
More complex _________ have unbranched or branched oligosachharide headgroups, containing up to 10 sugar residues
There are two strategies for the attachment of headgroups, via: (i) activated _________, or (ii) an activated __________
Sphingolipid with a phosphate group
Addition of sugars carried out by a series of _______ ______ (in Golgi) ______ at a time
________ are vinyl ether lipids, with an unsaturated double bond between C1 and C2 of the alkene chain.
sphinganine is an ___ carbon ______ ______
Cerebroside biosynthesis occurs through the use of ______ ______
Sphingolipids: Step 4: ________ attachment

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Sign Up with Email
Log In

You Might Also Like...

Show Comments


Top Quizzes Today

Score Distribution

Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.