Science Quiz / Schizophrenia and Depression

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Can you name the Schizophrenia and Depression

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CASIS cluster of early schizophrenia signs stands for...different domains
This disorder is twice as common in women as in men.
Haloperidol and phenothiazines (chlorpromazine) are examples of this kind of drug.
The ___ suppression test doesn't work in depressed individuals.Their cortisol levels go right back up.
The hypofrontality + glutamate + dopamine hypothesis begins with increased ___ ___ in adolescence.
These drugs inhibit reuptake of serotonin AND norephinephrine.Effexor, Pristiq, Cymbalta
Twins who share placenta are called...both have increased risk of schizophrenia.
Some ___ receptors form complexes with 5HT2A receptors, so when they are blocked the function of ___ receptors is increased.same word both blanks
To treat depression, TMS often targets this area.
If this gene is suppressed during progenitor phase, PFC neurons become abnormal after puberty.in fetal mice
Clozapine, risperidone, and olanzapine are this kind of drug.
Depressed patients have elevated circulating ___,
suggesting excessive ___ released by pituitary.
Normally, glutamate in PFC excites ___ in VTA which ___ release of dopamine to NAcc.Scz less glutamate, less ___, more dopamine in NAcc
These drugs inhibit reuptake of serotonin and norepinephrine.Desipramine, Imipramine, Clomipramine
Condition with high levels of circulating glucocorticoids.besides depression; a precursor?
Schizophrenia risk may be increased by this deficiency during gestation.
This depression is used more in older adults; memory loss is side effect.
This model of schizophrenia development involves stressors like urban living, birth complications, maternal illness during gestation.plus genetic susceptibility
This depressive tendency is associated with increased errors on the Wisconsin Card Sorting Task.
Common side effect of atypical neuroleptics.
The subgenual ACC is under the genu of the...
These are enlarged in both schizophrenia and bipolar disorder.predicts mediation response in scz
In this rare treatment for depression, a probe stimulates the subgenual cingulate cortex.
Atypical neuroleptics block these receptors in addition to D2 receptors.
HintAnswerExtra Info
ECT involves a shock throughout the ___.
Decreased emotional expression, eye tracking deficits, and motor problems are early signs of this disorder.
PCP is an antagonist of these receptors.Effects mimic schizophrenia symptoms
Elevated resting glucose metabolism in this area is associated with increased treatment response for depression
A treatment for depression is ___ ___ deprivation.
This disorder involves disorganization of pyramidal cells in the limbic system.
Common side effect of typical neuroleptics.odd muscle movements, esp oral
In schizophrenia, glutamate in the PFC is dysfunctional, leading to less inhibition by GABA from the VTA and increased dopamine in the
Reduced volume in this area predicts longer depression duration and is correlated with increased severity and worse executive function and attentional bias.
PCP and ___ cause scz-like symptoms by inhibiting NMDA receptor activity, esp in DLPFC.
Exposure to this disease during gestation increases risk of developing schizophrenia by 10-20x.
Atypical neuroleptics are ___ ___ of dopamine receptors.may increase DA in PFC and decrease in mesolimbic system
Schizophrenia Hypothesis: Dysfunction of DLPFC, reduced density dendritic spines in frontal cortex.
An NMDA antagonist will block the calcium channel, preventing ___ from having usual effects.
Typical neuroleptics block these receptors.
Reduced volume in this emotion regulation area is related to lower treatment response.reduced white matter integrity here associated with tx-refractory depression
Hypofrontality may be caused by decreased ___ in the PFC.
Schizophrenia Hypothesis: Positive symptoms caused by excessive neurotransmitter in mesolimbic pathway (VTA--NAcc).came from typical neuroleptic effectiveness
Exposure to this disease during gestation increases risk of schizophrenia by 3-7x.
These drugs inhibit the enzymatic breakdown of monoamines, but have broad action including in the gut.Nardil, Marplan, Parnate; also special diet to keep bp down
Schizophrenic patients typically have a ___ cortex.Thinner or thicker? +abnormal migration in frontal cortex
Diets low in this can lead to lower serotonin in the brain and relapse of depressive episode.
This theory of depression involves the neurotransmitters serotonin, dopamine, and norepinephrine.
This area shows reduced gray matter, but hyperactivity in depression.Direct connex to amygdala; target of DBS
Schizophrenia linked to smaller volume of these two structures in the limbic system.

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