Science Quiz / Cell Bio Test 4 Proteins/Molecules

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Can you name the Cell Bio Test 4 Proteins/Molecules?

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Rat Sarcoma, monomeric G-protein, membrane bound, proto-oncogene, activates Raf pathway
Lipid compound found in animal membranes, high concentration in membrane rafts, allow fluid movement of membrane elements
Type of receptor, ligand binds to a transmembrane channel that can open or close to allow ions into/out of cell
Removes phosphate groups from proteins
Transmembrane protein, binds to ECM and actin filaments
Between Actin and Microtubules in size, keratins, lamins, neurofilaments, vimentins, 10 nm
Converts ATP to cAMP, can be activated by alpha subunit of g-protein
Type of receptor, ligand passes through membrane and binds to receptor in cytosol, usually with steroid signals
Phospholipase C,has SH2 domain, phosphoylated form converts PIP2 into IP3 and DAG
Cytoskeletal motor protein, moves toward microtubule minus end, two heavy chain ends 'walk' along microtubule
Type of signal, usually peptide chemicals that exist in neurons, diffuse across synapse after action potential
Glucagon Pathway: Activated by phosphorylase kinase+ATP, converts glycogen to Glucose 1-Phosphate
Formation of eicosanoids, targeted by aspirin, NSAIDS
Part of MAPK pathway, has NLS, activates ELK1
Glycosaminoglycans, chain of carbohydrate, very polar, in joints, acts as a lubricant
Type of receptor, seven alpha helices across membrane, modified with carbohydrate on exterior, associated with heterotrimeric protein with GTPase activity
Straight, hollow cylinders, cell structure, spindle fibers, made of alpha & beta tubulin dimers, 25 nm, - end has alpha tubulin exposed, + end has beta tubulin exposed
Cytoskeletal motor protein, moves toward positive end of microtubule
Mitogen Activated Protein Kinase, series of Serine/ Threonine kinases, Raf, MEK, ERK, ELK1
Phosphoinositide Dependent Kinase 1, has PH domain to bind to PIP3, activates Akt
Desmosome that is connected to ECM rather than another cell, can include integrin proteins
Son of Sevenless, GEF protein for Ras, contains SH3 domain, binds to GRB2 at proline-rich sequences
HintAnswer
Mode of cell signaling, signals to nearby cells
Gas derived from arginine, diffuses across cell membranes, activates guanylyl cyclase in smooth muscle cells
Most common ECM protein, consists of a triple helix of polypeptide chains which pack together to form a large fibril, glycine and proline residues
Serine/Threonine kinase, activated by Ras, activates MAP, ERK Pathways
Modified lipid found in cell membranes, no net charge of head groups, plays roles in cell signaling
Scattered across basalateral surface, cadherins cross intercellular space, intermediate filaments connect cytoplasmic plaque to cytoskeleton
Globular form of actin, has ATPase activity to hydrolyze ATP into ADP
Binds to tubulin dimers, prevents microtubule formation
Type of signal, most common, include growth factors, bind to receptors
Forms microfilaments, has globular (G) or filament (F) form, connects transmembrane proteins, movement of cells, 7 nm
Type of signal, ringed fatty acids, lipid soluble, can pass through cell membranes
Sarcoma Homology 2, protein domain that binds to phosphorylated tyrosines and nearby residues, found in GRB2 bridge proteins
Membranes of adjacent cells form a seal with proteins, occluding, on basalateral surface near apical surface
Also known as Protein Kinase B, 'life protein', S/T kinase, activated by PIP3, signals for cell survival, has PH domain to bind to PIP3
Phosphorylated from PIP2 by PI-3 kinase, activates AKT, PDK1, both have PH domains
Glucagon Pathway: Kinase with 4 subunits-2 Receptor (R), 2 Catalytic (C), C-subunit has NLS, 2 cAMP molecules bind to each R group, releases and activates both C groups
Diacylglycerol, in membrane, formed from hydrolysis of PIP2, activates protein kinase C
Has two sites for binding Ca2+ ion on either end of protein, binds to Ca2+/Calmodulin dependent protein kinases
Disease caused by accumulation of beta amyloid protein in neurons, exacerbated by mutation in Presenilins I gene
Intermediate filament, makes up outer layer of skin, hair, and fingernails
cAMP Response Element Binding, Transcription Factor, binds to CRE, phosphorylated by C-subunit of PKA in nucleus with a cofactor, has two subunits that form a leucine zipper
Connexon channels that connect adjacent cells, channel crosses both membranes and intercellular space
HintAnswer
Transcription Factor, induces transcription of Bad and BIM- apoptosis genes, Akt Phosphorylates FOXO and inactivates it
Binds to beta tubulin, prevents depolymerization of microtubule of spindle fiber
29 residue protein, produced in response to low glucose levels by alpha cells of pancreas, targets liver cells
Inositol 1,4,5 Phosphate, hydrolyzed from PIP2, binds to ER channel to release Calcium Ions
Breaks 3' bond to phosphate group in cAMP to create 5' AMP
Transcription factor, helix-turn-helix, activated by ERK in MAPK pathway, binds to Serum Response Element (SRE)
Glucagon Pathway: Forms glycogen for storage, inactivated by PKA C-subunit+cAMP
Mechanistic Target of Rapamycin, activates Akt
Mode of cell signaling, signal targets signaling cell
Type of receptor, ligand activates receptor and generates a product or a response
Glucagon Pathway: Activated by C-subunit of PKA+ATP, activates Glycogen Phosphorylase with ATP
Phosphatidylinositol 4,5-bisphosphate, part on inner leaflet of membrane, fatty acid with attaced inositol with 3 phosphates
Actin filaments in cell bind to beta-catenins, cadherins bind to beta-catenins and cross intercellular space to form a lattice of structure
Mode of cell signaling, far distances, uses circulatory system
cAMP Response Element, sequence of DNA that can be bound by CREB, found in several genes, has sequence TGACGTAC
Alpha and Beta forms, dimers make up microtubules
Epidermal Growth Factor, binds to Receptor Tyrosine Kinases, stimulates cell growth, division, and differentiation
Nitric Oxide Synthetase, converts arginine into citrulline and nitric oxide with NADPH+O2
Enzyme receptor, consists of two transmembrane dimers, ligand binds to each receptor, causes dimerization, dimers phosphorylate tyrosines on each others' intracellular domain
Heterotrimeric chain of ECM, forms most of basal lamina, adhesion protein, one chain with two coiling chains
Type of signal, lipid signaling molecules, break down rapidly, used in paracrine and autocrine signaling, prostaglandin, prostacyclin

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