Science Quiz / Viral Drugs

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Can you name the Anti-Viral Drugs?

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Mechanism (+other info)Drug NameType
4x longer half-life than its counterpart, inhibit HIV integration into host
mcl Ab against against HIV
flu A and flu B, perenteral; NA inh for certain pts carrying H1N1, sold only in Jap and S Kor
mcl Ab against GP120, prevention drug, not treatment
mcl Ab against against HIV
PI function + boosts its counterpart (usually in HAART) by inhibiting CYP3A4
HIV, T-analog, azido group, triphosphorylated by host K, competitively inhibits viral RT; 100x affinity for viral host DNA pol (though mito pol sensitive)
altered G; monophospho by HSV TK, effective against HSV, VZV, not CMV; if IV then phlebitis may occur
inhibit HIV integration into host, used in monotherapy, pediatric use.
(two drugs) targets M2 of flu A (M2 is protein channel integral to flu A) --> inhibiting protein entry; GI and CNS effects also PD
Mechanism (+other info)Drug NameType
CMV-retinis, HIV1 and 2; inhibits DNA and RNA pol and RT, pyrophosphate mech
inhibits both replication and assembly, by cleaving nascent HIV proteins GAG and GAGPOL
IV; inhibits pore formation/entry, lines along the GP41 coil, preventing folding; reaction at injection site so need analgesics or new sites
flu A and flu B, inhibits neuraminidase, which cleaves the sialic acids, causes nausea, comiting, diarrhea and abdominal pain, not recommended for pts with COPD and asthma
HIV, A-analog, no-azido group, triphosphorylated by host K, competitively inhibits viral RT; causes nausea, vomiting, diarrhea and lethargy
G-analog, blocks replication, active against CMV retinitis,; needed in trasplantation, BM suppression, given w AZT side effects bad, resistance if viral UL97 kinase mutated
starts w N, inhibit RT allosterically by binding to NNRTI pocket, induces CYP3A4
flu A and flu B, resistance exists for this drug, also capsule or powder = high oral bioavail
starts w E, inhibit RT allosterically by binding to NNRTI pocket, induces CYP3A4

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Created Feb 11, 2012ReportNominate
Tags:drug, viral

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