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Can you name the PHAR 303 Random 2?

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name two in vitro skin corrosivity test kits
Cl found in the ___ position creates a non planar dioxin
IARC no carcinogenic for humans
The BaP_-_diol_-_epoxide is the carcinogenic one (fill the numbers)
measure the quality of vaccines and other drugs of bio origin and check for contamination
thalidomide as a therapeutic for
breast cancers cells make induce fibroblasts using these (2) cytokines
SHH signaling mechanism depends on this substance
subchronic tox dosage time vs assay time (m for month)
ethanol kills___ (3 words)
this method replaced GPMS
TCDD and dioxins binds to
IARC possible carcinogenic to humans
mech of thalidomide
the carcinogen that actually forms adducts and causes genotox
genotoxic carcinogens that do require bioactivation eg PAHs
name regulatory parameters (7)
this guy created teratogen principles
DES mechanisms (one word)
parent carciniogen that enters body is termed
term meaning to test for enviro effects of chemicals, used on fish, algae and water fleas
phorbols inhibit what
issues for scientists regarding animal testing (2)
Bacterial test seeing chemical is mutagen
Animal test assumptions (2)
reasosn for decrease of death from birth defect
issue for public regarding animal testing (2)
T or F: Retinoids affect homeobox gene
T or F: more animals are used in acute than in chronic toxicity
interdigitate deficiciencies caused by
Three stage of cancer (3) in order
planar or non planar cell binds AhR
T or F: UF and MF are unitless
T or F: MIR, ultrasound, CT, PET, SPECT, optical imaging are examples of non-invasive imaging in rodents
European committee validating alternative methods
TCDD is a what? starts with d
T or F: adipocytes have higher aromatase activity
structure activity relationship and kinetic modelling acronym
sex hormones DES and BPA binds to what receptor
EtOH while preggers leads to
non mutagenic carcinogens, alter DNA methylation, and cell prolif, homronal actions, enz induction etc, can be complete carcinogens by themselves
the major symptom of the teratogen thalidomide is
1931: his guy wrote really obvious things about use of experimental animals usch as do experiments with least infliction of suffering or avoid an exp if already done
name the refinement alternatives we covered (3 acronyms)
International/Interagency ECVAM
fibroblasts have inducible ____ activity
these mimic thyroid homrones, androgens or estrogens
genotoxic carcinogens that do not require bioactivations
IARC probably carcinogenic to humans
two types of toxicity tests, broad, (2)
disrupts cholesterol synthesis
what vitamin decreases incidence in neural tube defects and spina bifida
IARC agent is carcinogenic to humans
TCE or trichloroehtylene binds to what receptor
ethanol affects this HOX gene
name another indirect carcinogen that we covered that is not PAHs or aflotoxin
IARC not classifiable for humans
deaths of cancer for males due to cancer in this order (3)
Name one major drawback of in vitro skin irritancy tests
acute toxicology dosage time vs assay time
_-_quinone of estrogen is the highly mutagenic one
computational tox acronym
hypospadia, increased cryptominism, cancer, testicular cancer, symptoms of what
carcinogens that require bioactivation, and attach DNA , mutagenic, no theoretical threshold
name the three pluripotent embryonic stem cells we covered (3)
aromatases makes ___ into ___
T or F: pH, eval of skin irrit, strucutre activity relationship correlation, alternative tests, one animal two animals are the steps to avoiding the Draize test
intermediate btween procarcinogen and ultimate carcinogen
veratrum californicum is found in
the _-_ aflotoxin epoxide is the carcinogenic one
chronic toxicology dosage time vs assay time

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