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Can you name the PHAR 303 Random 2?

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HintAnswer
European committee validating alternative methods
fibroblasts have inducible ____ activity
genotoxic carcinogens that do require bioactivation eg PAHs
T or F: UF and MF are unitless
subchronic tox dosage time vs assay time (m for month)
T or F: adipocytes have higher aromatase activity
SHH signaling mechanism depends on this substance
T or F: more animals are used in acute than in chronic toxicity
the major symptom of the teratogen thalidomide is
IARC possible carcinogenic to humans
aromatases makes ___ into ___
_-_quinone of estrogen is the highly mutagenic one
sex hormones DES and BPA binds to what receptor
the carcinogen that actually forms adducts and causes genotox
thalidomide as a therapeutic for
reasosn for decrease of death from birth defect
T or F: MIR, ultrasound, CT, PET, SPECT, optical imaging are examples of non-invasive imaging in rodents
IARC no carcinogenic for humans
deaths of cancer for males due to cancer in this order (3)
what vitamin decreases incidence in neural tube defects and spina bifida
hypospadia, increased cryptominism, cancer, testicular cancer, symptoms of what
DES mechanisms (one word)
phorbols inhibit what
IARC probably carcinogenic to humans
HintAnswer
name the refinement alternatives we covered (3 acronyms)
T or F: pH, eval of skin irrit, strucutre activity relationship correlation, alternative tests, one animal two animals are the steps to avoiding the Draize test
1931: his guy wrote really obvious things about use of experimental animals usch as do experiments with least infliction of suffering or avoid an exp if already done
carcinogens that require bioactivation, and attach DNA , mutagenic, no theoretical threshold
non mutagenic carcinogens, alter DNA methylation, and cell prolif, homronal actions, enz induction etc, can be complete carcinogens by themselves
computational tox acronym
Name one major drawback of in vitro skin irritancy tests
veratrum californicum is found in
IARC agent is carcinogenic to humans
measure the quality of vaccines and other drugs of bio origin and check for contamination
EtOH while preggers leads to
T or F: Retinoids affect homeobox gene
issue for public regarding animal testing (2)
parent carciniogen that enters body is termed
TCE or trichloroehtylene binds to what receptor
acute toxicology dosage time vs assay time
these mimic thyroid homrones, androgens or estrogens
chronic toxicology dosage time vs assay time
IARC not classifiable for humans
disrupts cholesterol synthesis
this guy created teratogen principles
3Rs:
the _-_ aflotoxin epoxide is the carcinogenic one
Three stage of cancer (3) in order
HintAnswer
International/Interagency ECVAM
mech of thalidomide
this method replaced GPMS
genotoxic carcinogens that do not require bioactivations
name another indirect carcinogen that we covered that is not PAHs or aflotoxin
breast cancers cells make induce fibroblasts using these (2) cytokines
intermediate btween procarcinogen and ultimate carcinogen
ethanol affects this HOX gene
Animal test assumptions (2)
term meaning to test for enviro effects of chemicals, used on fish, algae and water fleas
name two in vitro skin corrosivity test kits
interdigitate deficiciencies caused by
planar or non planar cell binds AhR
name the three pluripotent embryonic stem cells we covered (3)
Cl found in the ___ position creates a non planar dioxin
The BaP_-_diol_-_epoxide is the carcinogenic one (fill the numbers)
ethanol kills___ (3 words)
TCDD and dioxins binds to
two types of toxicity tests, broad, (2)
issues for scientists regarding animal testing (2)
TCDD is a what? starts with d
name regulatory parameters (7)
structure activity relationship and kinetic modelling acronym
Bacterial test seeing chemical is mutagen

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Created Feb 15, 2012ReportNominate

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