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Can you name the PHAR 303 Random 2?

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HintAnswer
Bacterial test seeing chemical is mutagen
phorbols inhibit what
the _-_ aflotoxin epoxide is the carcinogenic one
aromatases makes ___ into ___
T or F: UF and MF are unitless
ethanol affects this HOX gene
carcinogens that require bioactivation, and attach DNA , mutagenic, no theoretical threshold
these mimic thyroid homrones, androgens or estrogens
_-_quinone of estrogen is the highly mutagenic one
term meaning to test for enviro effects of chemicals, used on fish, algae and water fleas
IARC probably carcinogenic to humans
name the three pluripotent embryonic stem cells we covered (3)
deaths of cancer for males due to cancer in this order (3)
T or F: more animals are used in acute than in chronic toxicity
1931: his guy wrote really obvious things about use of experimental animals usch as do experiments with least infliction of suffering or avoid an exp if already done
parent carciniogen that enters body is termed
disrupts cholesterol synthesis
Name one major drawback of in vitro skin irritancy tests
T or F: pH, eval of skin irrit, strucutre activity relationship correlation, alternative tests, one animal two animals are the steps to avoiding the Draize test
the carcinogen that actually forms adducts and causes genotox
sex hormones DES and BPA binds to what receptor
fibroblasts have inducible ____ activity
reasosn for decrease of death from birth defect
this guy created teratogen principles
HintAnswer
SHH signaling mechanism depends on this substance
mech of thalidomide
structure activity relationship and kinetic modelling acronym
two types of toxicity tests, broad, (2)
what vitamin decreases incidence in neural tube defects and spina bifida
the major symptom of the teratogen thalidomide is
IARC agent is carcinogenic to humans
The BaP_-_diol_-_epoxide is the carcinogenic one (fill the numbers)
non mutagenic carcinogens, alter DNA methylation, and cell prolif, homronal actions, enz induction etc, can be complete carcinogens by themselves
Three stage of cancer (3) in order
T or F: adipocytes have higher aromatase activity
IARC not classifiable for humans
issue for public regarding animal testing (2)
Animal test assumptions (2)
TCDD and dioxins binds to
hypospadia, increased cryptominism, cancer, testicular cancer, symptoms of what
3Rs:
T or F: Retinoids affect homeobox gene
name regulatory parameters (7)
interdigitate deficiciencies caused by
European committee validating alternative methods
genotoxic carcinogens that do require bioactivation eg PAHs
acute toxicology dosage time vs assay time
IARC possible carcinogenic to humans
HintAnswer
thalidomide as a therapeutic for
intermediate btween procarcinogen and ultimate carcinogen
EtOH while preggers leads to
breast cancers cells make induce fibroblasts using these (2) cytokines
Cl found in the ___ position creates a non planar dioxin
International/Interagency ECVAM
ethanol kills___ (3 words)
planar or non planar cell binds AhR
computational tox acronym
name the refinement alternatives we covered (3 acronyms)
this method replaced GPMS
TCDD is a what? starts with d
name another indirect carcinogen that we covered that is not PAHs or aflotoxin
measure the quality of vaccines and other drugs of bio origin and check for contamination
name two in vitro skin corrosivity test kits
DES mechanisms (one word)
IARC no carcinogenic for humans
chronic toxicology dosage time vs assay time
genotoxic carcinogens that do not require bioactivations
issues for scientists regarding animal testing (2)
TCE or trichloroehtylene binds to what receptor
veratrum californicum is found in
subchronic tox dosage time vs assay time (m for month)
T or F: MIR, ultrasound, CT, PET, SPECT, optical imaging are examples of non-invasive imaging in rodents

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Created Feb 15, 2012ReportNominate

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