Science Quiz / PHAR 303 Random 2

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Can you name the PHAR 303 Random 2?

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HintAnswer
EtOH while preggers leads to
1931: his guy wrote really obvious things about use of experimental animals usch as do experiments with least infliction of suffering or avoid an exp if already done
name another indirect carcinogen that we covered that is not PAHs or aflotoxin
breast cancers cells make induce fibroblasts using these (2) cytokines
non mutagenic carcinogens, alter DNA methylation, and cell prolif, homronal actions, enz induction etc, can be complete carcinogens by themselves
disrupts cholesterol synthesis
IARC no carcinogenic for humans
IARC possible carcinogenic to humans
mech of thalidomide
The BaP_-_diol_-_epoxide is the carcinogenic one (fill the numbers)
the carcinogen that actually forms adducts and causes genotox
structure activity relationship and kinetic modelling acronym
interdigitate deficiciencies caused by
parent carciniogen that enters body is termed
issues for scientists regarding animal testing (2)
reasosn for decrease of death from birth defect
DES mechanisms (one word)
issue for public regarding animal testing (2)
T or F: UF and MF are unitless
IARC probably carcinogenic to humans
International/Interagency ECVAM
T or F: more animals are used in acute than in chronic toxicity
T or F: adipocytes have higher aromatase activity
phorbols inhibit what
HintAnswer
_-_quinone of estrogen is the highly mutagenic one
thalidomide as a therapeutic for
T or F: MIR, ultrasound, CT, PET, SPECT, optical imaging are examples of non-invasive imaging in rodents
this guy created teratogen principles
this method replaced GPMS
computational tox acronym
3Rs:
Name one major drawback of in vitro skin irritancy tests
deaths of cancer for males due to cancer in this order (3)
SHH signaling mechanism depends on this substance
T or F: Retinoids affect homeobox gene
these mimic thyroid homrones, androgens or estrogens
intermediate btween procarcinogen and ultimate carcinogen
name regulatory parameters (7)
hypospadia, increased cryptominism, cancer, testicular cancer, symptoms of what
the _-_ aflotoxin epoxide is the carcinogenic one
genotoxic carcinogens that do not require bioactivations
sex hormones DES and BPA binds to what receptor
T or F: pH, eval of skin irrit, strucutre activity relationship correlation, alternative tests, one animal two animals are the steps to avoiding the Draize test
Three stage of cancer (3) in order
genotoxic carcinogens that do require bioactivation eg PAHs
TCE or trichloroehtylene binds to what receptor
Bacterial test seeing chemical is mutagen
acute toxicology dosage time vs assay time
HintAnswer
TCDD and dioxins binds to
term meaning to test for enviro effects of chemicals, used on fish, algae and water fleas
European committee validating alternative methods
planar or non planar cell binds AhR
name the refinement alternatives we covered (3 acronyms)
name the three pluripotent embryonic stem cells we covered (3)
ethanol affects this HOX gene
chronic toxicology dosage time vs assay time
TCDD is a what? starts with d
fibroblasts have inducible ____ activity
subchronic tox dosage time vs assay time (m for month)
the major symptom of the teratogen thalidomide is
ethanol kills___ (3 words)
IARC agent is carcinogenic to humans
Animal test assumptions (2)
carcinogens that require bioactivation, and attach DNA , mutagenic, no theoretical threshold
veratrum californicum is found in
IARC not classifiable for humans
two types of toxicity tests, broad, (2)
aromatases makes ___ into ___
measure the quality of vaccines and other drugs of bio origin and check for contamination
what vitamin decreases incidence in neural tube defects and spina bifida
Cl found in the ___ position creates a non planar dioxin
name two in vitro skin corrosivity test kits

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Created Feb 15, 2012ReportNominate

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