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Can you name the PHAR 303 Random 2?

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TCDD is a what? starts with d
ethanol affects this HOX gene
EtOH while preggers leads to
term meaning to test for enviro effects of chemicals, used on fish, algae and water fleas
what vitamin decreases incidence in neural tube defects and spina bifida
this guy created teratogen principles
reasosn for decrease of death from birth defect
genotoxic carcinogens that do not require bioactivations
acute toxicology dosage time vs assay time
genotoxic carcinogens that do require bioactivation eg PAHs
the carcinogen that actually forms adducts and causes genotox
hypospadia, increased cryptominism, cancer, testicular cancer, symptoms of what
TCE or trichloroehtylene binds to what receptor
T or F: pH, eval of skin irrit, strucutre activity relationship correlation, alternative tests, one animal two animals are the steps to avoiding the Draize test
two types of toxicity tests, broad, (2)
International/Interagency ECVAM
disrupts cholesterol synthesis
name the three pluripotent embryonic stem cells we covered (3)
IARC agent is carcinogenic to humans
breast cancers cells make induce fibroblasts using these (2) cytokines
European committee validating alternative methods
IARC no carcinogenic for humans
Name one major drawback of in vitro skin irritancy tests
the _-_ aflotoxin epoxide is the carcinogenic one
IARC possible carcinogenic to humans
subchronic tox dosage time vs assay time (m for month)
issue for public regarding animal testing (2)
planar or non planar cell binds AhR
these mimic thyroid homrones, androgens or estrogens
carcinogens that require bioactivation, and attach DNA , mutagenic, no theoretical threshold
deaths of cancer for males due to cancer in this order (3)
parent carciniogen that enters body is termed
interdigitate deficiciencies caused by
Animal test assumptions (2)
measure the quality of vaccines and other drugs of bio origin and check for contamination
name regulatory parameters (7)
mech of thalidomide
non mutagenic carcinogens, alter DNA methylation, and cell prolif, homronal actions, enz induction etc, can be complete carcinogens by themselves
name the refinement alternatives we covered (3 acronyms)
The BaP_-_diol_-_epoxide is the carcinogenic one (fill the numbers)
chronic toxicology dosage time vs assay time
1931: his guy wrote really obvious things about use of experimental animals usch as do experiments with least infliction of suffering or avoid an exp if already done
T or F: UF and MF are unitless
T or F: adipocytes have higher aromatase activity
T or F: more animals are used in acute than in chronic toxicity
issues for scientists regarding animal testing (2)
_-_quinone of estrogen is the highly mutagenic one
name another indirect carcinogen that we covered that is not PAHs or aflotoxin
Bacterial test seeing chemical is mutagen
DES mechanisms (one word)
veratrum californicum is found in
intermediate btween procarcinogen and ultimate carcinogen
T or F: Retinoids affect homeobox gene
phorbols inhibit what
aromatases makes ___ into ___
computational tox acronym
Three stage of cancer (3) in order
the major symptom of the teratogen thalidomide is
TCDD and dioxins binds to
name two in vitro skin corrosivity test kits
ethanol kills___ (3 words)
fibroblasts have inducible ____ activity
IARC probably carcinogenic to humans
T or F: MIR, ultrasound, CT, PET, SPECT, optical imaging are examples of non-invasive imaging in rodents
IARC not classifiable for humans
sex hormones DES and BPA binds to what receptor
structure activity relationship and kinetic modelling acronym
Cl found in the ___ position creates a non planar dioxin
this method replaced GPMS
thalidomide as a therapeutic for
SHH signaling mechanism depends on this substance

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