Science Quiz / PHAR 303 Random 2

Random Science Quiz
Score 0/72 Timer 20:00
HintAnswer
this method replaced GPMS
breast cancers cells make induce fibroblasts using these (2) cytokines
interdigitate deficiciencies caused by
issues for scientists regarding animal testing (2)
veratrum californicum is found in
term meaning to test for enviro effects of chemicals, used on fish, algae and water fleas
reasosn for decrease of death from birth defect
non mutagenic carcinogens, alter DNA methylation, and cell prolif, homronal actions, enz induction etc, can be complete carcinogens by themselves
IARC possible carcinogenic to humans
parent carciniogen that enters body is termed
TCDD is a what? starts with d
thalidomide as a therapeutic for
what vitamin decreases incidence in neural tube defects and spina bifida
intermediate btween procarcinogen and ultimate carcinogen
acute toxicology dosage time vs assay time
TCE or trichloroehtylene binds to what receptor
the _-_ aflotoxin epoxide is the carcinogenic one
IARC agent is carcinogenic to humans
disrupts cholesterol synthesis
T or F: UF and MF are unitless
IARC no carcinogenic for humans
3Rs:
T or F: MIR, ultrasound, CT, PET, SPECT, optical imaging are examples of non-invasive imaging in rodents
1931: his guy wrote really obvious things about use of experimental animals usch as do experiments with least infliction of suffering or avoid an exp if already done
HintAnswer
ethanol kills___ (3 words)
IARC not classifiable for humans
T or F: more animals are used in acute than in chronic toxicity
_-_quinone of estrogen is the highly mutagenic one
International/Interagency ECVAM
two types of toxicity tests, broad, (2)
The BaP_-_diol_-_epoxide is the carcinogenic one (fill the numbers)
these mimic thyroid homrones, androgens or estrogens
structure activity relationship and kinetic modelling acronym
the carcinogen that actually forms adducts and causes genotox
phorbols inhibit what
this guy created teratogen principles
issue for public regarding animal testing (2)
T or F: adipocytes have higher aromatase activity
T or F: pH, eval of skin irrit, strucutre activity relationship correlation, alternative tests, one animal two animals are the steps to avoiding the Draize test
genotoxic carcinogens that do require bioactivation eg PAHs
planar or non planar cell binds AhR
aromatases makes ___ into ___
the major symptom of the teratogen thalidomide is
chronic toxicology dosage time vs assay time
Cl found in the ___ position creates a non planar dioxin
Bacterial test seeing chemical is mutagen
carcinogens that require bioactivation, and attach DNA , mutagenic, no theoretical threshold
subchronic tox dosage time vs assay time (m for month)
HintAnswer
name the three pluripotent embryonic stem cells we covered (3)
DES mechanisms (one word)
ethanol affects this HOX gene
deaths of cancer for males due to cancer in this order (3)
hypospadia, increased cryptominism, cancer, testicular cancer, symptoms of what
Name one major drawback of in vitro skin irritancy tests
sex hormones DES and BPA binds to what receptor
mech of thalidomide
name another indirect carcinogen that we covered that is not PAHs or aflotoxin
SHH signaling mechanism depends on this substance
genotoxic carcinogens that do not require bioactivations
T or F: Retinoids affect homeobox gene
name regulatory parameters (7)
fibroblasts have inducible ____ activity
EtOH while preggers leads to
IARC probably carcinogenic to humans
Three stage of cancer (3) in order
European committee validating alternative methods
name the refinement alternatives we covered (3 acronyms)
TCDD and dioxins binds to
computational tox acronym
name two in vitro skin corrosivity test kits
measure the quality of vaccines and other drugs of bio origin and check for contamination
Animal test assumptions (2)
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Created Feb 15, 2012ReportNominate

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