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Can you name the PHAR 303 Random 2?

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HintAnswer
name another indirect carcinogen that we covered that is not PAHs or aflotoxin
carcinogens that require bioactivation, and attach DNA , mutagenic, no theoretical threshold
structure activity relationship and kinetic modelling acronym
this method replaced GPMS
disrupts cholesterol synthesis
genotoxic carcinogens that do require bioactivation eg PAHs
T or F: Retinoids affect homeobox gene
acute toxicology dosage time vs assay time
TCDD is a what? starts with d
Name one major drawback of in vitro skin irritancy tests
interdigitate deficiciencies caused by
EtOH while preggers leads to
T or F: UF and MF are unitless
planar or non planar cell binds AhR
SHH signaling mechanism depends on this substance
the major symptom of the teratogen thalidomide is
Bacterial test seeing chemical is mutagen
name two in vitro skin corrosivity test kits
TCDD and dioxins binds to
fibroblasts have inducible ____ activity
term meaning to test for enviro effects of chemicals, used on fish, algae and water fleas
T or F: adipocytes have higher aromatase activity
3Rs:
_-_quinone of estrogen is the highly mutagenic one
HintAnswer
subchronic tox dosage time vs assay time (m for month)
breast cancers cells make induce fibroblasts using these (2) cytokines
aromatases makes ___ into ___
ethanol kills___ (3 words)
genotoxic carcinogens that do not require bioactivations
IARC no carcinogenic for humans
veratrum californicum is found in
two types of toxicity tests, broad, (2)
intermediate btween procarcinogen and ultimate carcinogen
thalidomide as a therapeutic for
deaths of cancer for males due to cancer in this order (3)
name the refinement alternatives we covered (3 acronyms)
chronic toxicology dosage time vs assay time
ethanol affects this HOX gene
The BaP_-_diol_-_epoxide is the carcinogenic one (fill the numbers)
issue for public regarding animal testing (2)
T or F: MIR, ultrasound, CT, PET, SPECT, optical imaging are examples of non-invasive imaging in rodents
these mimic thyroid homrones, androgens or estrogens
European committee validating alternative methods
non mutagenic carcinogens, alter DNA methylation, and cell prolif, homronal actions, enz induction etc, can be complete carcinogens by themselves
TCE or trichloroehtylene binds to what receptor
reasosn for decrease of death from birth defect
1931: his guy wrote really obvious things about use of experimental animals usch as do experiments with least infliction of suffering or avoid an exp if already done
measure the quality of vaccines and other drugs of bio origin and check for contamination
HintAnswer
Animal test assumptions (2)
IARC probably carcinogenic to humans
the carcinogen that actually forms adducts and causes genotox
phorbols inhibit what
issues for scientists regarding animal testing (2)
IARC not classifiable for humans
International/Interagency ECVAM
what vitamin decreases incidence in neural tube defects and spina bifida
T or F: pH, eval of skin irrit, strucutre activity relationship correlation, alternative tests, one animal two animals are the steps to avoiding the Draize test
name the three pluripotent embryonic stem cells we covered (3)
name regulatory parameters (7)
computational tox acronym
the _-_ aflotoxin epoxide is the carcinogenic one
Cl found in the ___ position creates a non planar dioxin
IARC agent is carcinogenic to humans
sex hormones DES and BPA binds to what receptor
parent carciniogen that enters body is termed
mech of thalidomide
T or F: more animals are used in acute than in chronic toxicity
DES mechanisms (one word)
Three stage of cancer (3) in order
IARC possible carcinogenic to humans
hypospadia, increased cryptominism, cancer, testicular cancer, symptoms of what
this guy created teratogen principles

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