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Can you name the PHAR 303 Random 2?

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HintAnswer
International/Interagency ECVAM
fibroblasts have inducible ____ activity
Bacterial test seeing chemical is mutagen
T or F: Retinoids affect homeobox gene
deaths of cancer for males due to cancer in this order (3)
Animal test assumptions (2)
mech of thalidomide
issues for scientists regarding animal testing (2)
The BaP_-_diol_-_epoxide is the carcinogenic one (fill the numbers)
structure activity relationship and kinetic modelling acronym
DES mechanisms (one word)
planar or non planar cell binds AhR
European committee validating alternative methods
IARC probably carcinogenic to humans
IARC not classifiable for humans
carcinogens that require bioactivation, and attach DNA , mutagenic, no theoretical threshold
Name one major drawback of in vitro skin irritancy tests
IARC possible carcinogenic to humans
T or F: MIR, ultrasound, CT, PET, SPECT, optical imaging are examples of non-invasive imaging in rodents
the carcinogen that actually forms adducts and causes genotox
non mutagenic carcinogens, alter DNA methylation, and cell prolif, homronal actions, enz induction etc, can be complete carcinogens by themselves
these mimic thyroid homrones, androgens or estrogens
what vitamin decreases incidence in neural tube defects and spina bifida
veratrum californicum is found in
HintAnswer
computational tox acronym
1931: his guy wrote really obvious things about use of experimental animals usch as do experiments with least infliction of suffering or avoid an exp if already done
Three stage of cancer (3) in order
SHH signaling mechanism depends on this substance
ethanol affects this HOX gene
ethanol kills___ (3 words)
T or F: pH, eval of skin irrit, strucutre activity relationship correlation, alternative tests, one animal two animals are the steps to avoiding the Draize test
TCDD and dioxins binds to
breast cancers cells make induce fibroblasts using these (2) cytokines
IARC agent is carcinogenic to humans
Cl found in the ___ position creates a non planar dioxin
parent carciniogen that enters body is termed
thalidomide as a therapeutic for
the major symptom of the teratogen thalidomide is
measure the quality of vaccines and other drugs of bio origin and check for contamination
this guy created teratogen principles
TCE or trichloroehtylene binds to what receptor
genotoxic carcinogens that do not require bioactivations
hypospadia, increased cryptominism, cancer, testicular cancer, symptoms of what
TCDD is a what? starts with d
IARC no carcinogenic for humans
two types of toxicity tests, broad, (2)
term meaning to test for enviro effects of chemicals, used on fish, algae and water fleas
name regulatory parameters (7)
HintAnswer
phorbols inhibit what
genotoxic carcinogens that do require bioactivation eg PAHs
reasosn for decrease of death from birth defect
3Rs:
issue for public regarding animal testing (2)
EtOH while preggers leads to
intermediate btween procarcinogen and ultimate carcinogen
name two in vitro skin corrosivity test kits
sex hormones DES and BPA binds to what receptor
chronic toxicology dosage time vs assay time
_-_quinone of estrogen is the highly mutagenic one
the _-_ aflotoxin epoxide is the carcinogenic one
T or F: more animals are used in acute than in chronic toxicity
T or F: adipocytes have higher aromatase activity
T or F: UF and MF are unitless
subchronic tox dosage time vs assay time (m for month)
name another indirect carcinogen that we covered that is not PAHs or aflotoxin
name the refinement alternatives we covered (3 acronyms)
interdigitate deficiciencies caused by
acute toxicology dosage time vs assay time
disrupts cholesterol synthesis
name the three pluripotent embryonic stem cells we covered (3)
aromatases makes ___ into ___
this method replaced GPMS

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