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Distrubution occurs via two systems:
IOC banned this before 1976 olympics in mtl
3 components of health risk assessment:
recombination: During G2, use of 2 chromatids, using one as template, less error prone than counterpart
a big confounding factor
plant toxin that could kill you in small amounts
T or F: p is long arm
acetylation of amine groups done by?
this group created the IOC
four ways to dope (4 single acronyms) in right order
sequential SNPs, or alleles, on sinle chr, rare sep by recombination
measure of distribution
eg of hormesis given by TS (4 full name)
1952 Act to clean England's airs
probit unit 3-7 would include what % of pop
key word for epidemiology: study of ___ that modify health
Recombination repair consists of these 2:
mech of shiga toxin (2)
endogenous frameshift inducer
movement through cells
1947: act saying that a susbtance that was neither drug had to be shown to be safe and efficacious
three grid system soil samplings (3)
uncontrollable and not observable eg
act requiring data on food, drug and cometics additives
pesticide list, 2000 active ingredients, on this list
ways to create DNA-protein cross link
extraction is the process of making a ____ sample
Germany 2011 epidemiology example
study that looks for a correlation, can't set causation, ODDS ratio
tributyltin is a ____ (class of compound)
recombination: Grabs a piece of DNA not sister chromatid and can lead to chromo aberrations
study that gives probable causation, retrospective only, disease vs non-disease, trying to figure what crucial factor is
Assumptions underying DE relationship (3)
T or F: saturation kinetics involves half-lives
this is a mutation hotspot
movement between cells
positive y-intercept DR extrapolation name
Canada's FDA
way to create DS break
outcomes of toxicodynamics (3, single words)
agent caues gain or less of chr during chromatin condensation
group of people together that came down with something
greater or equal to one million pounds/yr
four assesment of toxicodynamics (4) in right order
Repair pathways (4, use acronyms)
T or F: increase of rare disease, increase in an unusual population and increase in common disease / rare disease, unusual pop and common disease are presentation of disease cluste
T or F: LD50 must be extrapolated
indirubins bind this at low conc
two types of exposures (2 single) in lecture 5 MC
study that takes a group of people, one factor and see outcomes, can be prospective or retro
T or F: UDS preferably on non-prolif cells (because S-phase has strong BrdU staining)
NER and two types of repair
Pharmacodynamics two ways (mech) (2, many words)
a single base change in DNA observed among individuals groups, or pop occuring in at least 1% of pop, neither detrimental nor beneficial
USA list of industrial chemicals (name)
First food and drug law (USA) to band elixirs and stuff and their poisonings
surface water sampled using this technique
sampling schemes (4) in the order in class
separation is usually done by ____ techniques
Canada's workplace safety
people have common polymorphisms in these type of enzymes
two types of reaction types (2)
three types of forensic toxicology (3) in right order
T or F: genital area less vulnerable than other areas
agent which induces increase freq of mutations
T or F: neoantigens can alter proteins directly or indirectly
identification is usually done by (3)
T or F: coroners have judicial role while medical have to be doctors; they deal with live patients
why results don't match with study (3 factors, single words)
Indirect detection of DNA damage (1 way)
this creates CPDs aka T=T
health risk perception two factors (2, single words)
T or F: acetylation is more active in caucasians than in asians
use of a substance by any route, for non-theapy reasons to enhance performance
codeine is broken down by which cyp
any substance foreign to a bio system
two contols for air pollution experiment (2)
Alter bio enviro 4 ways (4) right order
Mammalinan cytogenetic assays (3, use acronyms)
St anthony's fire fungal name
the primary substance, pure, not mix, that causes tox effect
attributes of target criteria (3) right order
PAHs causes which type of cancer
average number of SNPs in haplotype
RW Pount member of IOC creates this group, dedicated to test for doping drugs
99% of all males have T/E ratio of
tributyltin causes ____ in shellfish
measure of elim
name 3 kinetic 'special' locations (3 acronyms for 1)
4 types of mixture effects (4 single words)
T or F: industrial revolution = lots of development in tox field
small particles withing tiny water droplets, oth
list including substances used for manufacturing purposes or manufacture in or imported into Canada @ greater or equal to 100kg/year
name of extrapolation used for interactans and goes to zero on x-axis (1 word)
less than 1% of pop, usually harmful genomic change ass with human disease of increase or risk
three routes of exposure (3 single words) order we learned + 4th is injection
name of extrapolation linear straight to zero eg for carcinogens (1 word)
ways to create SS break
direct repair via this one-time-use enz
Xeroderma Pigmentosum XP is caused by defects in which enzymes
Test name for Arsenic
name the two combination sep/ID procedures we learned (2) right order
drug used in micronuclei assay to block further cell division
synthetic frameshift inducer
cell responses to DNA damage (2, single words)
agent to create DNA-DNA crosslink
HPLC, mass spec, immunodetection involved in detecting these
uses agarose gel, and measuring length of stuff
to hide presence of illegal drugs
three types of SNPs (3) right order
Identification of chr abnormalibity by molecular hybridization of a labelled DNA probe
T or F:single base substitution, indel, duplication, translocation / single base, insertion and deletion, duplication, and translocation are the four types of mutations
T or F: potency vs efficacity is pretty much horizontal shifts vs max y-value, repectively
useful of interchr rearrangements, has the word paint
Direct detection of DNA damage (3, two single words, one many)

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Created Feb 15, 2012ReportFavoriteNominate

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