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measure of distribution
positive y-intercept DR extrapolation name
two types of reaction types (2)
extraction is the process of making a ____ sample
ways to create DNA-protein cross link
group of people together that came down with something
pesticide list, 2000 active ingredients, on this list
Identification of chr abnormalibity by molecular hybridization of a labelled DNA probe
name of extrapolation linear straight to zero eg for carcinogens (1 word)
list including substances used for manufacturing purposes or manufacture in or imported into Canada @ greater or equal to 100kg/year
T or F: saturation kinetics involves half-lives
T or F: LD50 must be extrapolated
T or F: genital area less vulnerable than other areas
acetylation of amine groups done by?
USA list of industrial chemicals (name)
movement through cells
name 3 kinetic 'special' locations (3 acronyms for 1)
3 components of health risk assessment:
health risk perception two factors (2, single words)
St anthony's fire fungal name
outcomes of toxicodynamics (3, single words)
PAHs causes which type of cancer
this is a mutation hotspot
this group created the IOC
study that looks for a correlation, can't set causation, ODDS ratio
three types of SNPs (3) right order
greater or equal to one million pounds/yr
T or F: acetylation is more active in caucasians than in asians
codeine is broken down by which cyp
drug used in micronuclei assay to block further cell division
ways to create SS break
T or F: industrial revolution = lots of development in tox field
1952 Act to clean England's airs
measure of elim
First food and drug law (USA) to band elixirs and stuff and their poisonings
4 types of mixture effects (4 single words)
indirubins bind this at low conc
Xeroderma Pigmentosum XP is caused by defects in which enzymes
this creates CPDs aka T=T
Alter bio enviro 4 ways (4) right order
cell responses to DNA damage (2, single words)
agent to create DNA-DNA crosslink
small particles withing tiny water droplets, oth
T or F: neoantigens can alter proteins directly or indirectly
four ways to dope (4 single acronyms) in right order
a big confounding factor
Test name for Arsenic
tributyltin causes ____ in shellfish
four assesment of toxicodynamics (4) in right order
three grid system soil samplings (3)
Canada's workplace safety
study that takes a group of people, one factor and see outcomes, can be prospective or retro
two contols for air pollution experiment (2)
name the two combination sep/ID procedures we learned (2) right order
1947: act saying that a susbtance that was neither drug had to be shown to be safe and efficacious
T or F: potency vs efficacity is pretty much horizontal shifts vs max y-value, repectively
separation is usually done by ____ techniques
T or F: UDS preferably on non-prolif cells (because S-phase has strong BrdU staining)
use of a substance by any route, for non-theapy reasons to enhance performance
T or F:single base substitution, indel, duplication, translocation / single base, insertion and deletion, duplication, and translocation are the four types of mutations
direct repair via this one-time-use enz
name of extrapolation used for interactans and goes to zero on x-axis (1 word)
three types of forensic toxicology (3) in right order
plant toxin that could kill you in small amounts
surface water sampled using this technique
sampling schemes (4) in the order in class
mech of shiga toxin (2)
IOC banned this before 1976 olympics in mtl
endogenous frameshift inducer
T or F: p is long arm
identification is usually done by (3)
study that gives probable causation, retrospective only, disease vs non-disease, trying to figure what crucial factor is
eg of hormesis given by TS (4 full name)
movement between cells
any substance foreign to a bio system
agent caues gain or less of chr during chromatin condensation
two types of exposures (2 single) in lecture 5 MC
Distrubution occurs via two systems:
people have common polymorphisms in these type of enzymes
Assumptions underying DE relationship (3)
Recombination repair consists of these 2:
synthetic frameshift inducer
average number of SNPs in haplotype
uncontrollable and not observable eg
Canada's FDA
a single base change in DNA observed among individuals groups, or pop occuring in at least 1% of pop, neither detrimental nor beneficial
recombination: During G2, use of 2 chromatids, using one as template, less error prone than counterpart
99% of all males have T/E ratio of
Indirect detection of DNA damage (1 way)
three routes of exposure (3 single words) order we learned + 4th is injection
probit unit 3-7 would include what % of pop
T or F: coroners have judicial role while medical have to be doctors; they deal with live patients
Repair pathways (4, use acronyms)
RW Pount member of IOC creates this group, dedicated to test for doping drugs
attributes of target criteria (3) right order
Direct detection of DNA damage (3, two single words, one many)
HPLC, mass spec, immunodetection involved in detecting these
why results don't match with study (3 factors, single words)
useful of interchr rearrangements, has the word paint
Mammalinan cytogenetic assays (3, use acronyms)
less than 1% of pop, usually harmful genomic change ass with human disease of increase or risk
Pharmacodynamics two ways (mech) (2, many words)
sequential SNPs, or alleles, on sinle chr, rare sep by recombination
to hide presence of illegal drugs
uses agarose gel, and measuring length of stuff
NER and two types of repair
way to create DS break
recombination: Grabs a piece of DNA not sister chromatid and can lead to chromo aberrations
act requiring data on food, drug and cometics additives
Germany 2011 epidemiology example
T or F: increase of rare disease, increase in an unusual population and increase in common disease / rare disease, unusual pop and common disease are presentation of disease cluste
tributyltin is a ____ (class of compound)
agent which induces increase freq of mutations
key word for epidemiology: study of ___ that modify health
the primary substance, pure, not mix, that causes tox effect

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