Science Quiz / PHAR 303 Random

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Can you name the PHAR 303 Random?

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any substance foreign to a bio system
LD1/ED99
direct repair via this one-time-use enz
Canada's workplace safety
Recombination repair consists of these 2:
1947: act saying that a susbtance that was neither drug had to be shown to be safe and efficacious
three types of forensic toxicology (3) in right order
list including substances used for manufacturing purposes or manufacture in or imported into Canada @ greater or equal to 100kg/year
T or F: p is long arm
synthetic frameshift inducer
endogenous frameshift inducer
ways to create SS break
pesticide list, 2000 active ingredients, on this list
small particles withing tiny water droplets, oth
T or F: coroners have judicial role while medical have to be doctors; they deal with live patients
probit unit 3-7 would include what % of pop
to hide presence of illegal drugs
recombination: During G2, use of 2 chromatids, using one as template, less error prone than counterpart
agent caues gain or less of chr during chromatin condensation
extraction is the process of making a ____ sample
USA list of industrial chemicals (name)
movement between cells
measure of elim
mech of shiga toxin (2)
recombination: Grabs a piece of DNA not sister chromatid and can lead to chromo aberrations
way to create DS break
Identification of chr abnormalibity by molecular hybridization of a labelled DNA probe
key word for epidemiology: study of ___ that modify health
three routes of exposure (3 single words) order we learned + 4th is injection
this creates CPDs aka T=T
surface water sampled using this technique
separation is usually done by ____ techniques
positive y-intercept DR extrapolation name
less than 1% of pop, usually harmful genomic change ass with human disease of increase or risk
four assesment of toxicodynamics (4) in right order
study that gives probable causation, retrospective only, disease vs non-disease, trying to figure what crucial factor is
Distrubution occurs via two systems:
Alter bio enviro 4 ways (4) right order
two types of exposures (2 single) in lecture 5 MC
HintAnswer
uses agarose gel, and measuring length of stuff
tributyltin is a ____ (class of compound)
useful of interchr rearrangements, has the word paint
a big confounding factor
two contols for air pollution experiment (2)
plant toxin that could kill you in small amounts
attributes of target criteria (3) right order
ways to create DNA-protein cross link
eg of hormesis given by TS (4 full name)
cell responses to DNA damage (2, single words)
name the two combination sep/ID procedures we learned (2) right order
Indirect detection of DNA damage (1 way)
T or F: potency vs efficacity is pretty much horizontal shifts vs max y-value, repectively
greater or equal to one million pounds/yr
the primary substance, pure, not mix, that causes tox effect
name of extrapolation used for interactans and goes to zero on x-axis (1 word)
four ways to dope (4 single acronyms) in right order
T or F: LD50 must be extrapolated
codeine is broken down by which cyp
PAHs causes which type of cancer
St anthony's fire fungal name
T or F: acetylation is more active in caucasians than in asians
this group created the IOC
T or F: genital area less vulnerable than other areas
this is a mutation hotspot
T or F: neoantigens can alter proteins directly or indirectly
use of a substance by any route, for non-theapy reasons to enhance performance
three types of SNPs (3) right order
outcomes of toxicodynamics (3, single words)
indirubins bind this at low conc
drug used in micronuclei assay to block further cell division
study that takes a group of people, one factor and see outcomes, can be prospective or retro
sampling schemes (4) in the order in class
4 types of mixture effects (4 single words)
three grid system soil samplings (3)
RW Pount member of IOC creates this group, dedicated to test for doping drugs
Direct detection of DNA damage (3, two single words, one many)
HPLC, mass spec, immunodetection involved in detecting these
Mammalinan cytogenetic assays (3, use acronyms)
HintAnswer
T or F:single base substitution, indel, duplication, translocation / single base, insertion and deletion, duplication, and translocation are the four types of mutations
Assumptions underying DE relationship (3)
name of extrapolation linear straight to zero eg for carcinogens (1 word)
1952 Act to clean England's airs
99% of all males have T/E ratio of
uncontrollable and not observable eg
sequential SNPs, or alleles, on sinle chr, rare sep by recombination
Test name for Arsenic
3 components of health risk assessment:
IOC banned this before 1976 olympics in mtl
movement through cells
name 3 kinetic 'special' locations (3 acronyms for 1)
group of people together that came down with something
T or F: industrial revolution = lots of development in tox field
average number of SNPs in haplotype
LD50/ED50
Germany 2011 epidemiology example
two types of reaction types (2)
Repair pathways (4, use acronyms)
tributyltin causes ____ in shellfish
T or F: saturation kinetics involves half-lives
NER and two types of repair
why results don't match with study (3 factors, single words)
Pharmacodynamics two ways (mech) (2, many words)
T or F: increase of rare disease, increase in an unusual population and increase in common disease / rare disease, unusual pop and common disease are presentation of disease cluste
health risk perception two factors (2, single words)
measure of distribution
a single base change in DNA observed among individuals groups, or pop occuring in at least 1% of pop, neither detrimental nor beneficial
Xeroderma Pigmentosum XP is caused by defects in which enzymes
acetylation of amine groups done by?
First food and drug law (USA) to band elixirs and stuff and their poisonings
Canada's FDA
act requiring data on food, drug and cometics additives
T or F: UDS preferably on non-prolif cells (because S-phase has strong BrdU staining)
people have common polymorphisms in these type of enzymes
study that looks for a correlation, can't set causation, ODDS ratio
agent to create DNA-DNA crosslink
identification is usually done by (3)
agent which induces increase freq of mutations

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Created Feb 15, 2012ReportNominate

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