Science Quiz / PHAR 303 Random

Random Science Quiz
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HintAnswer
extraction is the process of making a ____ sample
greater or equal to one million pounds/yr
useful of interchr rearrangements, has the word paint
agent caues gain or less of chr during chromatin condensation
this creates CPDs aka T=T
people have common polymorphisms in these type of enzymes
a big confounding factor
average number of SNPs in haplotype
three routes of exposure (3 single words) order we learned + 4th is injection
positive y-intercept DR extrapolation name
this group created the IOC
pesticide list, 2000 active ingredients, on this list
Direct detection of DNA damage (3, two single words, one many)
study that looks for a correlation, can't set causation, ODDS ratio
use of a substance by any route, for non-theapy reasons to enhance performance
99% of all males have T/E ratio of
ways to create SS break
way to create DS break
two types of exposures (2 single) in lecture 5 MC
LD1/ED99
St anthony's fire fungal name
this is a mutation hotspot
direct repair via this one-time-use enz
agent which induces increase freq of mutations
IOC banned this before 1976 olympics in mtl
attributes of target criteria (3) right order
Canada's workplace safety
small particles withing tiny water droplets, oth
a single base change in DNA observed among individuals groups, or pop occuring in at least 1% of pop, neither detrimental nor beneficial
Canada's FDA
LD50/ED50
name of extrapolation linear straight to zero eg for carcinogens (1 word)
Alter bio enviro 4 ways (4) right order
separation is usually done by ____ techniques
probit unit 3-7 would include what % of pop
T or F: UDS preferably on non-prolif cells (because S-phase has strong BrdU staining)
T or F: saturation kinetics involves half-lives
codeine is broken down by which cyp
synthetic frameshift inducer
HintAnswer
list including substances used for manufacturing purposes or manufacture in or imported into Canada @ greater or equal to 100kg/year
key word for epidemiology: study of ___ that modify health
outcomes of toxicodynamics (3, single words)
three types of SNPs (3) right order
why results don't match with study (3 factors, single words)
eg of hormesis given by TS (4 full name)
to hide presence of illegal drugs
1952 Act to clean England's airs
uncontrollable and not observable eg
study that gives probable causation, retrospective only, disease vs non-disease, trying to figure what crucial factor is
acetylation of amine groups done by?
recombination: Grabs a piece of DNA not sister chromatid and can lead to chromo aberrations
Mammalinan cytogenetic assays (3, use acronyms)
T or F: potency vs efficacity is pretty much horizontal shifts vs max y-value, repectively
name the two combination sep/ID procedures we learned (2) right order
Test name for Arsenic
drug used in micronuclei assay to block further cell division
uses agarose gel, and measuring length of stuff
4 types of mixture effects (4 single words)
identification is usually done by (3)
1947: act saying that a susbtance that was neither drug had to be shown to be safe and efficacious
First food and drug law (USA) to band elixirs and stuff and their poisonings
ways to create DNA-protein cross link
two types of reaction types (2)
name of extrapolation used for interactans and goes to zero on x-axis (1 word)
sequential SNPs, or alleles, on sinle chr, rare sep by recombination
indirubins bind this at low conc
Identification of chr abnormalibity by molecular hybridization of a labelled DNA probe
Indirect detection of DNA damage (1 way)
recombination: During G2, use of 2 chromatids, using one as template, less error prone than counterpart
surface water sampled using this technique
T or F: genital area less vulnerable than other areas
movement through cells
T or F: industrial revolution = lots of development in tox field
Assumptions underying DE relationship (3)
three grid system soil samplings (3)
endogenous frameshift inducer
measure of distribution
T or F: LD50 must be extrapolated
HintAnswer
Germany 2011 epidemiology example
Distrubution occurs via two systems:
NER and two types of repair
group of people together that came down with something
less than 1% of pop, usually harmful genomic change ass with human disease of increase or risk
T or F: neoantigens can alter proteins directly or indirectly
Xeroderma Pigmentosum XP is caused by defects in which enzymes
mech of shiga toxin (2)
tributyltin causes ____ in shellfish
sampling schemes (4) in the order in class
HPLC, mass spec, immunodetection involved in detecting these
Recombination repair consists of these 2:
cell responses to DNA damage (2, single words)
any substance foreign to a bio system
Repair pathways (4, use acronyms)
T or F: p is long arm
the primary substance, pure, not mix, that causes tox effect
name 3 kinetic 'special' locations (3 acronyms for 1)
two contols for air pollution experiment (2)
T or F: coroners have judicial role while medical have to be doctors; they deal with live patients
movement between cells
health risk perception two factors (2, single words)
T or F:single base substitution, indel, duplication, translocation / single base, insertion and deletion, duplication, and translocation are the four types of mutations
tributyltin is a ____ (class of compound)
Pharmacodynamics two ways (mech) (2, many words)
three types of forensic toxicology (3) in right order
four ways to dope (4 single acronyms) in right order
PAHs causes which type of cancer
T or F: increase of rare disease, increase in an unusual population and increase in common disease / rare disease, unusual pop and common disease are presentation of disease cluste
measure of elim
RW Pount member of IOC creates this group, dedicated to test for doping drugs
plant toxin that could kill you in small amounts
four assesment of toxicodynamics (4) in right order
study that takes a group of people, one factor and see outcomes, can be prospective or retro
T or F: acetylation is more active in caucasians than in asians
agent to create DNA-DNA crosslink
USA list of industrial chemicals (name)
act requiring data on food, drug and cometics additives
3 components of health risk assessment:

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