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sampling schemes (4) in the order in class
PAHs causes which type of cancer
Germany 2011 epidemiology example
indirubins bind this at low conc
Direct detection of DNA damage (3, two single words, one many)
probit unit 3-7 would include what % of pop
Pharmacodynamics two ways (mech) (2, many words)
T or F:single base substitution, indel, duplication, translocation / single base, insertion and deletion, duplication, and translocation are the four types of mutations
list including substances used for manufacturing purposes or manufacture in or imported into Canada @ greater or equal to 100kg/year
three routes of exposure (3 single words) order we learned + 4th is injection
pesticide list, 2000 active ingredients, on this list
T or F: p is long arm
four ways to dope (4 single acronyms) in right order
1947: act saying that a susbtance that was neither drug had to be shown to be safe and efficacious
Alter bio enviro 4 ways (4) right order
IOC banned this before 1976 olympics in mtl
this creates CPDs aka T=T
acetylation of amine groups done by?
three types of forensic toxicology (3) in right order
any substance foreign to a bio system
tributyltin is a ____ (class of compound)
health risk perception two factors (2, single words)
T or F: acetylation is more active in caucasians than in asians
to hide presence of illegal drugs
ways to create SS break
uncontrollable and not observable eg
name 3 kinetic 'special' locations (3 acronyms for 1)
T or F: coroners have judicial role while medical have to be doctors; they deal with live patients
movement between cells
surface water sampled using this technique
T or F: neoantigens can alter proteins directly or indirectly
average number of SNPs in haplotype
useful of interchr rearrangements, has the word paint
Canada's FDA
outcomes of toxicodynamics (3, single words)
Canada's workplace safety
USA list of industrial chemicals (name)
Distrubution occurs via two systems:
two contols for air pollution experiment (2)
St anthony's fire fungal name
act requiring data on food, drug and cometics additives
less than 1% of pop, usually harmful genomic change ass with human disease of increase or risk
people have common polymorphisms in these type of enzymes
Repair pathways (4, use acronyms)
attributes of target criteria (3) right order
study that looks for a correlation, can't set causation, ODDS ratio
3 components of health risk assessment:
1952 Act to clean England's airs
a single base change in DNA observed among individuals groups, or pop occuring in at least 1% of pop, neither detrimental nor beneficial
sequential SNPs, or alleles, on sinle chr, rare sep by recombination
cell responses to DNA damage (2, single words)
small particles withing tiny water droplets, oth
plant toxin that could kill you in small amounts
HPLC, mass spec, immunodetection involved in detecting these
Recombination repair consists of these 2:
four assesment of toxicodynamics (4) in right order
measure of elim
name of extrapolation linear straight to zero eg for carcinogens (1 word)
endogenous frameshift inducer
extraction is the process of making a ____ sample
Test name for Arsenic
way to create DS break
uses agarose gel, and measuring length of stuff
this is a mutation hotspot
T or F: industrial revolution = lots of development in tox field
mech of shiga toxin (2)
use of a substance by any route, for non-theapy reasons to enhance performance
Indirect detection of DNA damage (1 way)
Mammalinan cytogenetic assays (3, use acronyms)
name the two combination sep/ID procedures we learned (2) right order
codeine is broken down by which cyp
key word for epidemiology: study of ___ that modify health
two types of exposures (2 single) in lecture 5 MC
name of extrapolation used for interactans and goes to zero on x-axis (1 word)
study that takes a group of people, one factor and see outcomes, can be prospective or retro
tributyltin causes ____ in shellfish
group of people together that came down with something
greater or equal to one million pounds/yr
agent caues gain or less of chr during chromatin condensation
T or F: potency vs efficacity is pretty much horizontal shifts vs max y-value, repectively
this group created the IOC
99% of all males have T/E ratio of
RW Pount member of IOC creates this group, dedicated to test for doping drugs
ways to create DNA-protein cross link
NER and two types of repair
Identification of chr abnormalibity by molecular hybridization of a labelled DNA probe
positive y-intercept DR extrapolation name
a big confounding factor
T or F: increase of rare disease, increase in an unusual population and increase in common disease / rare disease, unusual pop and common disease are presentation of disease cluste
measure of distribution
recombination: During G2, use of 2 chromatids, using one as template, less error prone than counterpart
Xeroderma Pigmentosum XP is caused by defects in which enzymes
separation is usually done by ____ techniques
agent which induces increase freq of mutations
First food and drug law (USA) to band elixirs and stuff and their poisonings
three types of SNPs (3) right order
synthetic frameshift inducer
movement through cells
4 types of mixture effects (4 single words)
why results don't match with study (3 factors, single words)
identification is usually done by (3)
study that gives probable causation, retrospective only, disease vs non-disease, trying to figure what crucial factor is
T or F: saturation kinetics involves half-lives
Assumptions underying DE relationship (3)
direct repair via this one-time-use enz
recombination: Grabs a piece of DNA not sister chromatid and can lead to chromo aberrations
T or F: UDS preferably on non-prolif cells (because S-phase has strong BrdU staining)
T or F: genital area less vulnerable than other areas
three grid system soil samplings (3)
the primary substance, pure, not mix, that causes tox effect
T or F: LD50 must be extrapolated
eg of hormesis given by TS (4 full name)
two types of reaction types (2)
agent to create DNA-DNA crosslink
drug used in micronuclei assay to block further cell division

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