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a big confounding factor
name of extrapolation linear straight to zero eg for carcinogens (1 word)
T or F: neoantigens can alter proteins directly or indirectly
movement between cells
uses agarose gel, and measuring length of stuff
Canada's FDA
study that gives probable causation, retrospective only, disease vs non-disease, trying to figure what crucial factor is
recombination: During G2, use of 2 chromatids, using one as template, less error prone than counterpart
1952 Act to clean England's airs
Canada's workplace safety
small particles withing tiny water droplets, oth
T or F: potency vs efficacity is pretty much horizontal shifts vs max y-value, repectively
the primary substance, pure, not mix, that causes tox effect
Test name for Arsenic
Germany 2011 epidemiology example
IOC banned this before 1976 olympics in mtl
Indirect detection of DNA damage (1 way)
Assumptions underying DE relationship (3)
mech of shiga toxin (2)
tributyltin causes ____ in shellfish
outcomes of toxicodynamics (3, single words)
study that looks for a correlation, can't set causation, ODDS ratio
Pharmacodynamics two ways (mech) (2, many words)
uncontrollable and not observable eg
First food and drug law (USA) to band elixirs and stuff and their poisonings
Identification of chr abnormalibity by molecular hybridization of a labelled DNA probe
agent caues gain or less of chr during chromatin condensation
RW Pount member of IOC creates this group, dedicated to test for doping drugs
recombination: Grabs a piece of DNA not sister chromatid and can lead to chromo aberrations
Xeroderma Pigmentosum XP is caused by defects in which enzymes
T or F: coroners have judicial role while medical have to be doctors; they deal with live patients
two contols for air pollution experiment (2)
tributyltin is a ____ (class of compound)
cell responses to DNA damage (2, single words)
T or F: acetylation is more active in caucasians than in asians
sampling schemes (4) in the order in class
T or F: LD50 must be extrapolated
attributes of target criteria (3) right order
name the two combination sep/ID procedures we learned (2) right order
surface water sampled using this technique
name 3 kinetic 'special' locations (3 acronyms for 1)
ways to create SS break
PAHs causes which type of cancer
Mammalinan cytogenetic assays (3, use acronyms)
synthetic frameshift inducer
key word for epidemiology: study of ___ that modify health
endogenous frameshift inducer
less than 1% of pop, usually harmful genomic change ass with human disease of increase or risk
HPLC, mass spec, immunodetection involved in detecting these
pesticide list, 2000 active ingredients, on this list
group of people together that came down with something
Alter bio enviro 4 ways (4) right order
two types of reaction types (2)
T or F: genital area less vulnerable than other areas
3 components of health risk assessment:
T or F: industrial revolution = lots of development in tox field
direct repair via this one-time-use enz
T or F:single base substitution, indel, duplication, translocation / single base, insertion and deletion, duplication, and translocation are the four types of mutations
to hide presence of illegal drugs
movement through cells
positive y-intercept DR extrapolation name
way to create DS break
eg of hormesis given by TS (4 full name)
four assesment of toxicodynamics (4) in right order
agent to create DNA-DNA crosslink
USA list of industrial chemicals (name)
this creates CPDs aka T=T
codeine is broken down by which cyp
useful of interchr rearrangements, has the word paint
health risk perception two factors (2, single words)
list including substances used for manufacturing purposes or manufacture in or imported into Canada @ greater or equal to 100kg/year
ways to create DNA-protein cross link
probit unit 3-7 would include what % of pop
use of a substance by any route, for non-theapy reasons to enhance performance
a single base change in DNA observed among individuals groups, or pop occuring in at least 1% of pop, neither detrimental nor beneficial
why results don't match with study (3 factors, single words)
this is a mutation hotspot
measure of distribution
Direct detection of DNA damage (3, two single words, one many)
T or F: increase of rare disease, increase in an unusual population and increase in common disease / rare disease, unusual pop and common disease are presentation of disease cluste
99% of all males have T/E ratio of
extraction is the process of making a ____ sample
average number of SNPs in haplotype
indirubins bind this at low conc
NER and two types of repair
measure of elim
acetylation of amine groups done by?
T or F: saturation kinetics involves half-lives
agent which induces increase freq of mutations
this group created the IOC
act requiring data on food, drug and cometics additives
greater or equal to one million pounds/yr
Distrubution occurs via two systems:
T or F: p is long arm
separation is usually done by ____ techniques
St anthony's fire fungal name
three types of SNPs (3) right order
people have common polymorphisms in these type of enzymes
4 types of mixture effects (4 single words)
drug used in micronuclei assay to block further cell division
Repair pathways (4, use acronyms)
T or F: UDS preferably on non-prolif cells (because S-phase has strong BrdU staining)
name of extrapolation used for interactans and goes to zero on x-axis (1 word)
four ways to dope (4 single acronyms) in right order
sequential SNPs, or alleles, on sinle chr, rare sep by recombination
three routes of exposure (3 single words) order we learned + 4th is injection
study that takes a group of people, one factor and see outcomes, can be prospective or retro
any substance foreign to a bio system
three types of forensic toxicology (3) in right order
1947: act saying that a susbtance that was neither drug had to be shown to be safe and efficacious
identification is usually done by (3)
Recombination repair consists of these 2:
two types of exposures (2 single) in lecture 5 MC
plant toxin that could kill you in small amounts
three grid system soil samplings (3)

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