Science Quiz / Atherosclerosis

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Can you name the Atherosclerosis?

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Example of post-translational import
Familial hypercholesterolemia is due to a mutation in the _________
Chylomcrions are transported to ____, _______, and _______
LDL Mechanism: ______ allow monocytes to get into the endothelium
Inherited elevated blood cholesterol
Oligosaccharides is ______ that is linked to amide nitrogen on _____
Liver turns chylomicrons into _________ which once taken up by cells are turned into _________
A hydroxyl radical and a lipid together react to get _____ and a ________radical
________ produces superoxide and peroxide continuously at low levels
LDL Mechanism: Monocytes become _________ and secrete ______
Co Import Mechanism: On the mRNA there is a ____ that ____ recognizes causing ____ to stop
LDL Mechanism: Macrophages ingest everything becoming _____ and eventually ____ occurs, dumping everything
Co Import Mechanism: ___ chops off the signal sequence
With clathrin surrounding the vesicle is it known as _____
Clathrin is made of __ heavy chains and __ light chains
The default destination for co import is ___
___ % of all cardiovascular deaths result from atherosclerosis
_____ are cholesterol synthesis inhibitors
Differential diagnoses: a tear in aorta
controlled tissue death
Blood type AB is known as universal _____ while type O is known as universal ________
Differential diagnoses: inflammation of gall bladder
LDLs are ____ and considered ___ cholesterol
Atherosclerosis pathogenesis: _____ form causing blockagein blood vessel
In Po import, a _____ directs protein to mitochondria
A _____ can direct a co-translation import somewhere specified
Differential diagnoses: inflammation of pericardium
excess sweating
LDLs are composed of a ____ membrane with an interior of _____ and _______
_____ enhances LDL uptake (drug)
Acid hydrolyases made in the ER are shipped to the _____ where enzymes recognize it and add a ________ group to it
Eample of co-translation import protein
Triglycerides are a preferred energy source for ____ and ____
strep throat bacteria, causes heart disease if untreated
The Nucleus has a ___ envelopes which is continuous with the ____ and _____
In famililal hypercholesterolemia, there is a mutation in the _____
LDLs are considered a _______ system
LDLs are marked by _____
In Po import, a _____ directs protein to nucleus
Middle layer of arteries is______ and it contains ___________ cells
The ER environemt _______ form, _______ of proteins occur, ______ off things occurs, and _______ assembly occurs, and _______
Atherosclerosis pathogenesis: Fat accumulation in intima
Atherosclerosis pathogenesis: Depots of fats that are under transparent layer of cells in intima
Transport: from the ER to outside
HDLs are also secreted by the liver and marked by _____, and once taken by cells are turned into
In the presence of ____ another lipid radical is formed (after o2)
Transport: from the outside to the ER
The environment of an endosome is ____
Not oxygenated
Protein imported into rough ER at the same time it is being translated
LDL Mechanism: LDL becomes _____, stimulating the ____ to recruit______
Antioxidants include: (4), with the last one cells make by themselves
______ terminates radical chain reactions
Oligosaccharides is _____ that is linked to hydroxyl oxygen on ______ or _________
An ____ protein links _____ to receptors (endocytosis)
The ___ has 70% of the body's LDL receptors
Differential diagnoses: gall stones
These act as handles or identifiers for lipoproteins
The layer of artery containing nerves, connective tissue, and fat
Most common surgery: removal of _____
Cholesterol goes to cells making enzymes in the ____ and inhibits them
In the presence of oxygen, lipid radicals turn into _______ radical and a _________ radical again
Protein manufactured in cytoplasm and then imported into rough ER
Disease of large and medium arteries, results in accumulates of smooth muscle cells and lipids within intima
In the endosome, ligands fall of because the _____, changes the _____ of proteins
Co Import Mechanism: The pore protein sits right above the _____, allowing the protein to be shoved into the lumen.
Atherosclerosis does not occur in the _____
Blood Types: The inheritance of _____ transferase for A antige, _____ transferase for B antigen
Hardening of arteries is _____ caused by ____ deposits in connective tissue
The _____ receptor recognizes mannose-6-phosphate and a _____ vesicle is made
O-linked are ____, while N-linked are ____
Atherosclerosis pathogenesis: Blood rip endothelial cells due ot force exposing media
Dietary ion-exchange resins bind to _____
For any tranfusion to work out, you need the same _____ type, ____ factor, and _____ complex
Clinical term for stroke
trouble breathing
A ____ sequence is 20 amino acids long, binding inside the pore membrane
the _________ and _________ reactions produce a ______ radical
Intima is composed of __________ and a ____ layer of _____ cells
Chest pain
LDL Mechanism: LDL floating around blood gets into the _______
Bacteria in athero plaques are the same as those in ______ disease
Co Import Mechanism: The _____ holds the ribosome, while _____ is used to boot out ____ to allow translation to start
Cell sorting facility
Uncontrolled tissue death
Clinical term for heart attack
____ binds to a protein made with an NLC signal and the ____ recognizes it and lets it in

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