Science Quiz / DNA Replication, Repair, & Recombination

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Can you name the relevant terms of DNA replication, repair, & recombination?

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ClueAnswer
True or false: while there are multiple origins of replication in the eukaryotic genome, there is still only one per chromosome.
This enzyme undoes coils formed upstream of the replication fork due to supercoiling.
_______ excision repair depends on removing an entire segment of DNA containing the defect, such as dimerized bases.
This is the most common nitrogenous base to dimerize in response to UV light exposure.
These proteins are present ONLY during S phase, due to the cell cycle's regulation, and are essential for loading helicase onto DNA.
These proteins are the first to bind to the bacterial chromosome in replication, and do so upstream of the DUE.
True or false: there is a biological advantage to limited mutation.
This is formed during recombination of sister chromatids; its resolution determines the ultimate resulting sequences.
______ excision repair is employed when a mismatched base must be removed, followed by the rest of the nucleotide.
This protein initiates recombination in meiosis.
Replication termination is signaled by ___ proteins binding to ___ sequences, causing the arrest of replication forks.
This type of recombination is limited to particular areas of the chromosome.
This is the most common cause of point deletions, due to hydrolytic attack between the nitrogenous base and sugar.
This segment of DNA at the origin of replication is where the strands first denature in replication.
The number of nucleotides processed by DNA polymerase before its dissociation from DNA is referred to as the polymerase's:
The protein complex that assembles at eukaryotic origins of replication:
The exonuclease activity of DNApol II proceeds in the _'-to-_' direction.
DNA replication is semiconservative, meaning that each daughter molecule has ___ original strand and ___ new strand.
ClueAnswer
Nonhomologous end joining as a form of double-stranded break repair is mediated by ____ proteins, but ultimately leads to the accrual of permanent DNA deletions called _____.
The origin of replication for the bacterial chromosome is also known as:
These proteins continually bind to isolated DNA strands during replication, in order to stabilize and protect them.
The enyzme _________ uses an internal RNA template to extend the ends of chromosomes as a safeguard against degradation, leaving a _' overhang that is tucked into the molecule.
The DUE is rich in the nitrogenous bases ________ and _______, enabling its rapid denaturation.
The helicase involved in DNA replication in eukaryotes is also known as this.
This form of double-stranded break repair depends on recombination with sister chromatids for more effective repair, and is thus limited to the S and G2 phases of the cell cycle.
This enzyme is coupled to polymerase, and unwinds the DNA at the replication fork.
These 'chunks' of DNA, produced during DNA elongation, are the only way to synthesize off the lagging strand, due to the unidirectionality of DNA polymerase.
Associated with each core polymerase domain is a ______, which holds the DNA in place.
This process proceeds DNA replication at eukaryotic origins.
The energy required for elongation in DNA synthesis is provided by the release of _________ from nucleotides.
Another form of DNA damage due to hydrolytic attack, where cytosine is converted to uracil.
Just type in 'heteroduplex'. I'm all quizzed out.
What two molecules can be DIRECTLY synthesized using DNA as a template?
Immediately following DNA replication in the bacterium, the daughter chromosomes are catenated. What TYPE of topoisomerase is required to separate them?
Because DNA polymerase can only polymerize existing nucleic acids, it requires an RNA _____ to begin elongation.

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