Science Quiz / MNE Metabolic Pathway Questions

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Can you name the Metabolic Components?

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HintAnswer
Mg2+ is a necessary cofactor for PFK-1, phosphoglycerate kinase, and which other enzyme?
ATP contains two high energy _______ bonds.
What is another name for the 'uncoupling protein' present in brown fat?
Which compound aids in the digestion of triacylglycerols (TAG's)?
Oxaloacetate is reduced to which compound before being imported inot the mitochondrial matrix?
Cyanide poisoning interferes with the normal functioning of which complex of the ETC?
Acetyl-CoA promotes the phosphorylation and subsequent inhibition of the E1 domain of the pyruvate dehyrdogenase complex. Which other compound promotes this phosphorylation?
Aspartate enters the mitochondrial matrix through an antiporter that exports which compound?
Which electron-carrier cofactor of the pyruvate dehydrogenase complex is riboflavin-based?
Which enzymatic portion of the pyruvate dehydrogenase complex carries out an irreversible step?
Beta-hydroxybutyrate is one ketone body that is able to be used for energy in peripheral tissues. What is the other?
Each of the following is a regulator of PFK-1 EXCEPT: citrate, succinate, AMP, ATP.
Which enzyme is responsible for the reaction that makes glucose unable to leave the cell?
Nucleotides, coenzymes, DNA, and RNA are all derived from which important derivative of the pentose phosphate pathway?
What thiamine deficiency disease is typically seen in anorexic patients?
Beta oxidation can be halted by inhibiting CAT1 (carnitine acyltransferase 1) with which intermediate of FA synthesis?
In the Metabolic Stress & Starvation module of self-directed learning videos, what is the name of the child who obtained his father's gun and got capped by his friend with it?
NADH can be generated in the brain from the breakdown of ketones using which enzyme?
Which cofactor of the pyruvate dehydrogenase complex is NOT dervied from a B vitamin?
In the heart, liver, and kidney, we use a slow shuttle system to replenish NAD+. What is its name?
Which enzyme is responsible for catalyzing the highly endergonic reaction of cleaving fructose-1,6-bisphosphate?
The reason the liver cannot utilize ketone bodies for energy is that it lacks this enzyme.
To prevent the F0F1 ATPase/ATP synthase enzyme from operating in the reverse direction during ischemia (lack of adequate oxygenation), this enzyme binds to the complex.
Pyruvate is the alpha ketoacid of which amino acid?
Acetyl-CoA is released from beta-ketoacyl-CoA by which enzyme of beta oxidation?
HintAnswer
Where in the cell is the pyruvate dehydrogenase complex located?
Beta oxidation of palmitate (16 carbon FA) yields how many acetyl-CoA molecules?
Oxygen radicals are cleared by which compound that is regenerated by a product of the pentose phosphate pathway?
Which cation activates enzymes in the TCA cycle?
The beta oxidation of odd-numbered FA chains will lead to which TCA intermediate?
This symporter utilizes the proton gradient to bring in a proton along with an inorganic phosphate molecule that will LATER be used to make ATP.
What is the alpha ketoacid of glutamate?
What is the alpha ketoacid of aspartate?
The enzyme PFK1, which carries out the first committed step of glycolysis, is inhibited by which TCA intermediate?
Low concentrations of oxaloacetate drive the reaction of this enzyme in the mitochondria, despite its unfavorable (positive) free energy change.
Which enzyme phosphorylates perilipin and hormone-sensitive lipase to allow for the relase of TAG's (triacylglycerols) into free FA's?
Ketogenesis starts with the reversal of the last step of which metabolic process?
Major up-regulators of the enzyme in the first committed step of glycolysis are ADP, AMP, and ____
The malate transporter is an antiporter that moves malate along with which other compound?
Citrate synthase, isocitrate dehydrogenase, and alpha ketoglutarate dehydrogenase all have in common that they are ACTIVATED (up-regulated) by ____
Pyruvate can be used to generate acetyl-CoA, oxaloacetate, and which other TCA intermediate?
Which cofactor of the pyruvate dehydrogenase complex is derived from pantothenic acid?
How many total protons are pumped into the intermembrane space of the mitochondria when electrons are input into the ETC in the form of succinate
How many protons are required to form 1 ATP using F0F1 ATP synthase?
Where is succinate dehydrogenase located in the cell?
Which enzyme of the TCA cycle can use either NADP+ or NAD+ to carry out its catalysis, depending on the particular isoform?
What is the oxidized form of the cofactor of glycerol-3-phosphate?
Which type of fuel can only provide a maximum of 30% of the brain's energy demands?
FA's are transported in aggregated compounds known as what?
What is the name of the three carbon compound that is left over at the end of beta oxidation of an odd-numbered FA chain?

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