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Antihypertensive Drugs Quiz Stats

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Hint Drug % Correct
Blocks Ang I-Ang II conversion in endothelial cells of the lung, leading to natriuresis, decreased TPR, decreased aldosterone, and increased Na excretion; can cause fetotoxicityCaptopril (Capoten), Lisinopril (Zestril), or Enalapril (Vasotec)
68.1%
Cardiosolective beta blockerAcebutolol (Sectral) or Metoprolol (Lopressor)
65.2%
Inhibits L-type Ca channels in the heart and vasculature, reducing contraction; this leads to lower contractility and CO in the heart, and reduced vasoconstriction and TPRVerapamil (Calan), Diltiazem (Cardizem), Nifedipine (Procardia), or Nicardipine (Cardene)
65.2%
Blocks AT1 receptors to induce vasodilation; also increases Na and water excretion; side effects include 1st dose hypotension, hyperkalemia, hepatic dysfunction, and fetotoxicityLosartan (Cozaar) or Valsartan (Diovan)
62.3%
Non-Selective beta blockerPropranolol (Inderal), Nadolol (Corgard), or Timolol (Blocadren)
60.9%
Alpha and beta blockerLabetalol (Normodyne) or Carvedilol (Coreg)
49.3%
Blocks peripheral postjunctional adrenergic receptors that cause contraction of vascular SM, decreases TPR and causes reflex increase in HRPrazosin (Minipress), Doxazosin (Cardura), or Terazosin (Hytrin)
47.8%
Depletes CNS and peripheral NE and 5-HT as well as adrenal catecholamines by interfering with storage vesicles; least desirable antihypertensive, but is cheap and effectiveReserpine
43.5%
Beta blocker with intrinsic sympathomimetic activityPindolol (Visken) or Oxprenolol (Trasicor)
43.5%
Unknown target; decreases TPR by relaxing arterioles; vasodilation is followed by reflex tachycardia, increased contractility and increased rennin secretionHydralazine (Apresoline)
43.5%
Hint Drug % Correct
Directly activates presynaptic alpha2-AR receptors; decreases SNS activity, no reflex, and reduces CO, HR, rennin release, and TPRClonidine (Catapres), Guanfacine (Tenex), or Guanabenz (Wytensin)
42%
Directly inhibits the protease activity of renin; causes vasodilation and natriuresis; side effects include 1st dose hypotension, hyperkalemia, angiodema, and fetotoxicityAliskiren (Tekturna)
42%
Decreases Co, HR, contractility, CNS outflow, and rennin release; side effects include bronchospasm, bradycardia, renal vasoconstriction, depression, bad dreams, and fatigueBeta-Blocker
36.2%
Red blood cells metabolize it into NO, which induces vascular SM relaxation in both arteries and veins; decreases TPR, but also venous poolingSodium Nitroprusside
34.8%
Opens K channels on SM; decreases TPR by relaxing arterioles; side effects include rapid drop in TPR, hypertrichosis, tachycardia, and fluid retentionMinoxidil (Loniten)
33.3%
Converted to a false transmitter in CNS neurons; acts centrally to decrease SNS activity, and reduces CO, HR, rennin release and TPRAlpha-methyl Dopa (Aldomet)
27.5%
Inhibits the synthesis of catecholamines by tyrosine hydroxylase; good for management of pheochromocytomaMetyrosine (Demser)
26.1%
Reduces SNS and PNS activity, decreasing TPR and CO; side effects include paralytic ileus, bladder dysfunction, constipation, postural hypotension, blurred vision, and dry mouthTrimethaphan, Mecamyline, or Hexamethonium
21.7%
Opens K channels on SM; decreases TPR by relaxing arterioles; side effects include rapid drop in TPR, and pronounced tachycardia, hyperglycemia, and hypertrichosisDiazoxide (Hyperstat IV)
21.7%
Replaces NE in secretory vesicles; does not cross blood-brain barrier, so no CNS effectsGuanadrel (Hylorel)
18.8%

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Created Oct 17, 2010ReportNominate
Tags:class, drug

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