Science Quiz / Antihypertensive Drugs

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HintDrugClass fo Drug
Reduces SNS and PNS activity, decreasing TPR and CO; side effects include paralytic ileus, bladder dysfunction, constipation, postural hypotension, blurred vision, and dry mouthGanglionic Blocker
Directly activates presynaptic alpha2-AR receptors; decreases SNS activity, no reflex, and reduces CO, HR, rennin release, and TPRAlpha2-AR Agonist
Inhibits L-type Ca channels in the heart and vasculature, reducing contraction; this leads to lower contractility and CO in the heart, and reduced vasoconstriction and TPRCa Channel Blocker
Blocks Ang I-Ang II conversion in endothelial cells of the lung, leading to natriuresis, decreased TPR, decreased aldosterone, and increased Na excretion; can cause fetotoxicityACE Inhibitor
Inhibits the synthesis of catecholamines by tyrosine hydroxylase; good for management of pheochromocytomaAdrenergic Neuronal Blocker
Depletes CNS and peripheral NE and 5-HT as well as adrenal catecholamines by interfering with storage vesicles; least desirable antihypertensive, but is cheap and effectiveAdrenergic Neuronal Blocker
Blocks peripheral postjunctional adrenergic receptors that cause contraction of vascular SM, decreases TPR and causes reflex increase in HRAlpha1-AR Antagonist
Beta blocker with intrinsic sympathomimetic activityBeta Blocker
Opens K channels on SM; decreases TPR by relaxing arterioles; side effects include rapid drop in TPR, and pronounced tachycardia, hyperglycemia, and hypertrichosisVasodilator
Blocks AT1 receptors to induce vasodilation; also increases Na and water excretion; side effects include 1st dose hypotension, hyperkalemia, hepatic dysfunction, and fetotoxicityAngiotensin Receptor Antagonist
HintDrugClass fo Drug
Unknown target; decreases TPR by relaxing arterioles; vasodilation is followed by reflex tachycardia, increased contractility and increased rennin secretionVasodilator
Decreases Co, HR, contractility, CNS outflow, and rennin release; side effects include bronchospasm, bradycardia, renal vasoconstriction, depression, bad dreams, and fatigueOther
Cardiosolective beta blockerBeta Blocker
Non-Selective beta blockerBeta Blocker
Directly inhibits the protease activity of renin; causes vasodilation and natriuresis; side effects include 1st dose hypotension, hyperkalemia, angiodema, and fetotoxicityRenin Inhibitor
Red blood cells metabolize it into NO, which induces vascular SM relaxation in both arteries and veins; decreases TPR, but also venous poolingVasodilator
Replaces NE in secretory vesicles; does not cross blood-brain barrier, so no CNS effectsAdrenergic Neuronal Blocker
Converted to a false transmitter in CNS neurons; acts centrally to decrease SNS activity, and reduces CO, HR, rennin release and TPROther
Opens K channels on SM; decreases TPR by relaxing arterioles; side effects include rapid drop in TPR, hypertrichosis, tachycardia, and fluid retentionVasodilator
Alpha and beta blockerBeta Blocker
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Created Oct 17, 2010ReportNominate
Tags:class, Drug

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