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Can you name the Virology 5240 Final Exam?

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The protection of cells infected with an HAD- virus against HAD+ viruses is _____ Interference
The discoverers of IFN
The set of polyoma genes which promotes VP Production/Apoptosis when inserted into the cell as one continuous segment
They discovered Viral Splicing in Adenoviridae by hybridizing hexon gene mRNA to DNA and noticing the loop outs, which were introns
The strain of Herpes responsible for chicken pox/Varicella Zoster Virus
(True/False): Cells which receive more than one VP still produce IFN
A protein which, in the IFN induction pathway, forms an active dimer when it binds dsRNA and activates NFkB, leading to IFN production
Mouse Mx accumulates in the ___; Human Mx accumulates in the ___
This element bound by NFkB and then binds the ISRE in the nucleus to produce IFN action-related gene products
Herpes viruses produce proteins in three stages, each of which translocate to the nucleus to promote the production of the next stage; the first stage is called:
Molecule produced by Polyomaviruses which pushes cells to the S phase, needed for viral replication
This family of enveloped dsDNA viruses with icosahedral nucleocapsids may take up a latent state in their host, forming a lifelong association with the virus
A protein produced by flu viruses which suppresses IFN induction by 'sponge'ing up cellular TFs
New membrane is added to cells at these end segments, making these the areas where HA is most likely to first appear
These poxvirus proteins allow for viral replication
(True/False): Vaccinia can protect co-infecting viruses from IFN effects by inhibiting PKR
This 'fishing' technique was used to distinguish between the two hypotheses of how DIPs functioned
Vaccinia codes for a this protein, a homolog of part of eIF2-alpha, the main target of PKR
A compound which, when phosphorylated, mimics a nucleotide and terminates DNA synthesis; phosphorylated by a thymadine kinase present only in Herpes-infected cells
(True/False): Adding a VSV gene to a pox virus and infecting a human with it will result in Ab against VSV
The interaction between different IFN families in a cell is described as:
A name for the secreted virulence factors of pox viruses
It was discovered that dsRNA induced IFN through experiments with these complimentary RNA compounds (answer: nucleotide letters)
Molecule produced by Polyomaviruses which binds p53, preventing apoptosis, promoting transformation
Vaccinia codes for this protein, which mimics PKR's ability to bind dsRNA ; adding a Reovirus gene to a deletion mutant replicates this function
(True/False): Cells which receive one IP do not always produce a full IFN yield
Cells induced to produce IFN are also induced to produce this compound to degrade the dsRNA
The strain of Herpes which causes Mononucleosis in America, but causes Burkitt's Lymphoma in areas with endemic malaria
As IFN levels in the blood rose, the number of vaccine 'takes' for measles ____
A gene which is activated by IFN, the product of which binds the flu virus nucleocapsid, blocking transcription of the genome
IFN-gamma upregulates the ____ Transcription Factor for IFN-alpha/beta, thereby increasing their effectiveness
He infected mice with viruses and then injected them with anti-IFN, resulting in increased lethality and demonstrating the power of IFN
Even though two infected monolayers may have received the same number of viral particles, those which were passed at high multiplicity will cyclically result in fewer PFP due to:
1 Unit of IFN is defined as the amount which results in a __% reduction in plaque formation
(True/False):Poxviruses (dsDNA) induce IFN through mechanisms not involving dsRNA
A poxvirus used by Burnett to control the Australian rabbit population
A protein in the IFN action pathway which, when activated with dsRNA, produces a protein which dimerizes and activates RNAse L
(True/False):RNAse L preferentially degrades ssRNA which is closely associated with dsRNA
(True/False): Production of DIPs depends on co-infection of the cell with complete virus
Strains specific virus interference which occurs when viruses are continuously passed at high titers
A trisomy of this chromosome, which produces the IFN receptor, will result in increased effectiveness of IFN
IFN acts as a natural ____, stimulating slow antigen release and increased antibody production
According to target theory, polyoma transforming activity declines more slowly than IP activity because _______ is the only target for transformation inhibition:
Proteins (Transcription Factors) abundant in Herpes viruses which are coded for by the virus
Latent Herpes RNA forms this shape in the nucleus of infected neurons:
This compound can separate HeLa cells from a plate while leaving the underlying HA molecules attached to be visualized
(True/False): Even if a cell is infected with an del-NS1 mutant, infection levels will remain high if the host lacks the PKR gene
The largest family of conventional viruses, these dsDNA viruses code for over 100 proteins and contain many TFs and Defense Mechanisms
The NS1 protein interacts with the polymerase complex, preventing its function
The set of polyoma genes which promotes transformation when inserted into the cell as one continuous segment
DIPs may be separated from PFPs with this technique, involving a sucrose density gradient
When chicken IFN was reverse transcribed into green monkey kidney cells and sequenced, the protein was found to have __ cysteines and __ glycsylation sites
IFN Receptors function via _____ pathways, ultimately phosphorylating IkB and thus activating NFkB
These poxvirus proteins produce a second stage uncoating; others exit the cell and stimulate adjacent cell growth; DNA not yet replicating
Outbreaks of this virus demonstrate the dangers other poxviruses pose in a world where no one is immune to smallpox, as poxviruses have common Ags provideing blanket pox immunity
This type of transcription of PFP RNA produces enough capsid proteins for DIP export in the absence of secondary transcription
Influenza DIPs disrupt replication because of a defective _____ subunit which outcompetes the normal protein
Interferon secondary structure contains 5 of these elements
Sustained Large T Antigen production is necessary to maintain a transformed cell, leading to a continuously fluorescent ______ when the LTA is GFP-tagged
(True/False): IFN Suppressing viruses are less sensitive to IFN action
A family of dsDNA viruses with circular supercoiled DNA wrapped around cellular histones
Poxviruses are fairly resistant to Antibody because they exit cells by _____, passing immediately into adjacent cells
(True/False): Interferon production in chicken embryos increases with time
Adenoviruses have this gene, which produces small dsRNA molecules that bind but do not activate PKR
The incredible stability of Herpesviridae allows for this technique to track the source of the infection
A homolog of the IFN-gamma receptor produced by myxoma virus, which reduces sensitivity to IFN
In the IFN action pathway, elevated PKR levels remain latent until dsRNA is present, at which point it phosphorylates __, stopping translation
NS1 (which also sequesters dsRNA) deletion mutants are equally sensitive to IFN action, but produce ___ IFN than normal virus
DIPs form in VSV because of a 5' end of the -RNA strand which transcribes a portion of the ___ gene, which then binds cellular transcriptase at high affinity
Herpes viruses produce these as a defense mechanism against IFN Action:
By infecting cells with a virus without a CPE (HAD-), waiting, and then challenging them with a virus with a CPE (HAD+), these appear on the plate
The most efficient inducer of IFN is a DIP of this virus
HPV (a polyomavirus) vaccines (against types 15+18) are made by inducing this organism to produce empty viral capsids

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