Science Quiz / Virology 5240 Exam 3

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Can you name the Virology Terms?

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An accessory auxiliary protein in HIV which causes the downregulation of CD4 and MHC class I on the cell surface, preventing further HIV infection of the cell and preventing immune
The prototypic Reovirus, with 10 genes, a two layer coat, and 12 vertices out of which the genome is released after lysosomal digestion
Noninfectious viral particles with truncated polymerase units; when they coinfect a cell along with a normal PFP, no IPs are produced
The prototypic oncovirus which results in insertional activation of c-onc
A drug which blocks the ion channel of the M2 Protein of Influenza, serving as a lysosomotrope
The naming scheme for influenza strains
Created a live attenuated polio vaccine by passing the virus so many times that it accumulated a large number of mutations
A -RNA virus family including Hantavirus
The protein product produced by src, the v-onc of RSV
The process that results from accumulations of point mutations, evidenced by the fact that after many passages an antibody against the original strain is less effective against the
A form of contact inhibition which does not restrict transformed cells, allowing them to grow to very high density
More basic amino acids, especially this amino acid, near the fusion protein tend to increase influenza pathogenicity
A +RNA family of virus including the Norwalk Virus
A +RNA family of virus including the Yellow Fever virus
Transformed cells are able to grow within soft agar, as they are no longer __________
Portions of the poliovirus genome which allow for ribosomal binding in lieu of cap binding complexes; they may be inserted in front of genes to engineer increased production
Of the 8 genes of influenza, these three are subunits of the polymerase
A polyprotein which weighs as much as the entire expected weights of all poliovirus gene products, indicating the translation of the whole genome at once
Retroviruses which are slow acting and tend to kill their host cell
The co-receptors (along with CD4) necessary for HIV uptake by cells, absent in ~10% of people
An influenza virus which is passaged at increasingly low temperatures so that it cannot replicate in the lower respiratory tract
These bind the two identical 35s RNA strands of retroviruses together as a single 70s unit, allowing RT to jump from one strand to the other to produce a complete genome
An influenza protein which facilitates the movement of the RNA into/out of the nucles
An influenza gene which produces two products: NEP and NS1
A protein produced by the PB1 gene which is associated with an increase in pathogenicity as a result of increased apoptosis; lacked by Swine H1N1
An influenza gene product which binds cellular TFs and DNA in a 'sponge like' manner, preventing cellular message expression; a defect will often allow for greater interferon induc
An inhibitor of DNA dependent RNA synthesis, used to show that influenza is dependent on DNA synthesis
A regulatory auxiliary protein in HIV which stimulates transcription of viral message by binding a looped out region known as TAR, promoting TF recruitment, hyperstimulating RNA Po
This region of retrovirus RNA/DNA attracts cellular polymerases and transcription factors, resulting in enhanced transcription
Enders/Wellers/Robin grew polio virus in these cells, rather than in neural cells where they have their action
Of the three capsid surface proteins of Reovirus, this protein was found to be responsible for sensitivity to activation via chymotrypsin by Fields
A virus which was given to many people as a result of growing polio in green monkey kidney cells
An antiviral drug which works by interfering with fidelity checkpoints, causing viruses to accumulate mutations
A compound used in conjuction with centrifugation to create a cytoplast, lacking a nucleus
The retrovirus gene segment consisting of the surface and transmembrane genes
The name for the circular loop of +/-DNA created by reverse transcriptase which is transported into the nuclease
A +RNA family of virus including the SARS virus
Conducted an experiment which suggested the existence of reverse transcriptase by using BUdR + serum starved cells in the S phase + RSV + serum + blue light to show that there was
A gene product produced by SV40 which disables p53, much as does HBV X protein
Cells in the respiratory tract which release a tryptase necessary for the presentation of the HA Fusion Protein
A process whereby influenza 'steals' the 7-methylguanosine cap from cellular mRNA, allowing the virus to undergo translation
Must be added to green monkey kidney cells in order to culture influenza on them, as it facilitates HA0 cleavage
Retroviruses which tend to transform their host cells
The retrovirus gene segment consisting of the matrix, capsid, nucleocapsid, and protease genes
A clump of cells which will form for each 10^4 RSV IPs added to a monolayer
Made a polio vaccine by using formalin to denature the virus while maintaining antigenicity; infected some patients due to viral clumping
A family of +/- dsRNA viruses containing Rotavirus, a leading cause of infant death
The retrovirus gene segment consisting of the reverse transcriptase and integrase genes
Complexes required by cellular mRNA for protein synthesis which are cleaved by poliovirus, preventing cells from expressing their own proteins
May be created by hybridizing a src deletion mutant's +RNA with normal -DNA produced by RSV RT; the src gene may then be cleaved with DNAse and used to probe the host cell genome f
Activation of a cellular oncogene due to the insertion of viral DNA next to the c-onc, resulting it its overtranscription
A type of RNA which can initially only translate one of two proteins due to a loop out, and which must be transcribed to produce the other gene product
Created by phenotypic mixing, these viruses may posses capsid proteins of two strains, making them doubly neutralizable
An increased amount of this activity, evidenced by the binding of plant lectins in tight clumps of receptors, demonstrates that a cell has been transformed
A regulatory auxiliary protein in HIV which binds RRE, allowing RNA to be exported from the nucleus to the cytoplasm
A family of -RNA viruses including Influenza
A +RNA family of virus including the Rubella Virus
An animal which often serves as a reservoir for multiple influenza strains, producing reassortants of difficult-to-predict pathogenicity
The process that results from significant genome changes due to reassortment
The enzyme which removes the +RNA strand from the -DNA strand produced by RT
A virus family in which the vaccine antigens were in fact enterotoxins
Seven additional genes present in HIV which allow it to better self-regulate
The cytokine used by Gallo to induce CD4+ T-cell division, allowing for the isolation of Human Lymphotropic Virus and eventually of HIV
A common anti-flu drug which is a competitive inhibitor of Neuraminidase, binding HA in lieu of sialic acid

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