Science Quiz / MCB 5217 Final

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QUIZ: Can you name the MCB Term?

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DescriptionTerm
The basic repeating structural unit of chromatin is the ___ which contains __ histone proteins present at __ copies
p15 ___ RNA silences the ___ in tumors
Two proteins which bind HP1:
Which class of HDACs does TSA inhibit?
Class II HDACs can shuttle from the ___ to the ___
In SILAC, proteins are distinguished by ___ due to the incorporation of ___
What type of sequnece keeps some DNA from becoming methylated?
mRNA facilitates ___ recycling and makes ___ more efficient
Where on mRNA do miRNAs usually bind
For transcription in vitro, what must be added first, TFs or nculeosome?
Which groove does DNAse I cut?
What type of gel system can be used to enumerate the number of acetlyated lysines on a histone protein?
Are most CpG dinucleotides methylated?
Which DNMT is a de novo DNA methyltransferase?
Rather than removing the nucleosome from DNA, SWI/SNF alters the ____ of DNA on the nucleosome
The ___ domain is found in many proteins associated with HMTs
Purified GCN5 can acetylate ___ but must be in a ___ complex to acetylate nucleosomes
The ___ sequencing assay is used to determine whether or not a cytosine is methylated
An ammended SILAC method:
How many bp are assosciated with a nucleosome?
HATs acetylate the ____
What enzyme processes a stem loop RNA into an miRNA?
Enzymes that catalyze the acetylation of histones are called
Which HMT methylates histone H3K27
mRNA will form a ___ to interact so proteins can bind to the ___ and ___
DNA with a high density of CpGs is associated with the decreased ___ of cytosines
List the Class I HDACS (1-8)
What is the ATPase subunit of the Rsc chromatin remodeling complex?
What type of phosphodiester bond is found in an mRNA cap?
MLL/SET I acetylates H3K_ and associates with the ____
DescriptionTerm
The miRNA strand chosen to target an mRNA has __ base pairing at the 5' end.
Prognosis for cancer patient with low HDAC activty:
Which tetrahymena nucleus is highly aceylated?
List 2 HDAC inhibitors
Which X chromosome in females is highly acetlyated?
The ___ group gene products are chromatin associated proteins required for repression of clustered homeotic genes
Methylation at H3K__ is associated with gene silencing, whereas H3K__ methylation is associated with gene expression
List 5 elements of mRNA structure
The ___ mutants do not allow haploid yeast to switch mating types.
Which DNMT is a maintenence DNA methyltransferase?
Where does the methyl group for histone methylation come from?
Class III HDACs like Sir2 require ___ to deacetylate histones
SWI/SNF complex uses ___ to travel down the ___ molecule
mRNA circularizes when 5' and 3' ends interact. This is thought to promote ____ and increased translation efficiency
2 mRNA molecules with AU-rich elements in their 3' UTR:
What does bisulfite convert unmethylated cytosine to?
CpG ___ are usually found near ___ and will remain unmethylated
How many times does DNA wrap around the nucleosome?
Which HMT methylates histone H3K9
What DNA sequence is methylated in mammals?
__ is used to determine rotational phasing, while ___ is used to determine translational phasing
Polycomb group genes ___ gene silencing
Which HMT methylates histone H3K4?
The histone ____tetramer forms the center of the nucleosome
What are the four human chromatin-remodeling machines?
Name two classic endocrine receptors
___ is an endonuclease that cleaves linker DNA
A stress granule stores ___ and prevents it from being ___
During myogenesis, class II HDACs regulate the activity of the ___ TF
SWI mutants cannot switch their mating type because they can't activate expression of the ___ gene
DescriptionTerm
Mutations in the ___ genes can suppress mating switch mutations in yeast.
___ contain de-capping enzymes, while ___ do not
___ can be used to determine which groove of the DNA is facing the nucleosome
Class I HDACs are frequently overexpressed in ___ cells
Which Ago protein will cleave target mRNA if a perfect match with the miRNA is formed?
(T/F): SWI mutations only affect mating type and have no other defects.
mRNA circularization offcurs as the result of an interaction between two proteins:
What was the first HAT to be identified? What species was it from?
Drosha is located in the ___
___ describes the position of the octomers
Where does the acetyl group for histone acetylation come from?
Do GCN4 and GCN5 both contain a DBD?
Which histone methylation is found in pericentromeric DNA?
What percentage of mRNAs can be regulated by an miRNA?
The TRX group proteins silence genes by methylaing promoter-associated nucleosomes at ___
Which type of miRNA gene targeting is most common in mammals? Degradation or inhibition?
Which chromatin is more transcriptionally active, euchromatin or heterochromatin?
The SAGA complex forms a bridge between ___ proteins and proteins in the ___
The GCN5 coactivator in the cell is part of a large complex called the ___complex
Trithorax group genes ___ gene silencing
Gal4 can bind nucleosome DNA once ___ has lifted its DBD off the nucleosome surface
What enzyme processes pre-miRNA to a stem loop?
Showing that the yeast ___ coactivator protein was a HAT provided evidence that acetylation was required for gene ___
(T/F): H3K6 methylation is more complex in plants than fungi/animals
As yeast age, circular fragments of ___ accumulate. This can be blocked by increased ___ gene expression
What does SILAC stand for?
DCP2 is the
Class ___ HDACs were identified as art of the aging pathway

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