Science Quiz / MCB 5217 Final

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Can you name the MCB Term?

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In SILAC, proteins are distinguished by ___ due to the incorporation of ___
Which HMT methylates histone H3K4?
During myogenesis, class II HDACs regulate the activity of the ___ TF
The ___ mutants do not allow haploid yeast to switch mating types.
What was the first HAT to be identified? What species was it from?
___ describes the position of the octomers
Where does the acetyl group for histone acetylation come from?
Which DNMT is a de novo DNA methyltransferase?
Which Ago protein will cleave target mRNA if a perfect match with the miRNA is formed?
Showing that the yeast ___ coactivator protein was a HAT provided evidence that acetylation was required for gene ___
2 mRNA molecules with AU-rich elements in their 3' UTR:
Prognosis for cancer patient with low HDAC activty:
Class III HDACs like Sir2 require ___ to deacetylate histones
What type of sequnece keeps some DNA from becoming methylated?
What type of phosphodiester bond is found in an mRNA cap?
An ammended SILAC method:
Two proteins which bind HP1:
What enzyme processes a stem loop RNA into an miRNA?
What does SILAC stand for?
Where does the methyl group for histone methylation come from?
Which class of HDACs does TSA inhibit?
mRNA facilitates ___ recycling and makes ___ more efficient
HATs acetylate the ____
Which DNMT is a maintenence DNA methyltransferase?
Are most CpG dinucleotides methylated?
Class I HDACs are frequently overexpressed in ___ cells
___ is an endonuclease that cleaves linker DNA
The ___ group gene products are chromatin associated proteins required for repression of clustered homeotic genes
How many bp are assosciated with a nucleosome?
Which type of miRNA gene targeting is most common in mammals? Degradation or inhibition?
Purified GCN5 can acetylate ___ but must be in a ___ complex to acetylate nucleosomes
Trithorax group genes ___ gene silencing
mRNA circularizes when 5' and 3' ends interact. This is thought to promote ____ and increased translation efficiency
The TRX group proteins silence genes by methylaing promoter-associated nucleosomes at ___
What percentage of mRNAs can be regulated by an miRNA?
The miRNA strand chosen to target an mRNA has __ base pairing at the 5' end.
The SAGA complex forms a bridge between ___ proteins and proteins in the ___
What are the four human chromatin-remodeling machines?
Methylation at H3K__ is associated with gene silencing, whereas H3K__ methylation is associated with gene expression
mRNA will form a ___ to interact so proteins can bind to the ___ and ___
SWI/SNF complex uses ___ to travel down the ___ molecule
Drosha is located in the ___
The histone ____tetramer forms the center of the nucleosome
Rather than removing the nucleosome from DNA, SWI/SNF alters the ____ of DNA on the nucleosome
SWI mutants cannot switch their mating type because they can't activate expression of the ___ gene
For transcription in vitro, what must be added first, TFs or nculeosome?
A stress granule stores ___ and prevents it from being ___
Class ___ HDACs were identified as art of the aging pathway
Which HMT methylates histone H3K27
Where on mRNA do miRNAs usually bind
Which histone methylation is found in pericentromeric DNA?
(T/F): SWI mutations only affect mating type and have no other defects.
Which HMT methylates histone H3K9
List the Class I HDACS (1-8)
List 2 HDAC inhibitors
Which groove does DNAse I cut?
The GCN5 coactivator in the cell is part of a large complex called the ___complex
What DNA sequence is methylated in mammals?
MLL/SET I acetylates H3K_ and associates with the ____
__ is used to determine rotational phasing, while ___ is used to determine translational phasing
DNA with a high density of CpGs is associated with the decreased ___ of cytosines
Which tetrahymena nucleus is highly aceylated?
Class II HDACs can shuttle from the ___ to the ___
List 5 elements of mRNA structure
The basic repeating structural unit of chromatin is the ___ which contains __ histone proteins present at __ copies
p15 ___ RNA silences the ___ in tumors
What does bisulfite convert unmethylated cytosine to?
mRNA circularization offcurs as the result of an interaction between two proteins:
___ can be used to determine which groove of the DNA is facing the nucleosome
Do GCN4 and GCN5 both contain a DBD?
How many times does DNA wrap around the nucleosome?
The ___ sequencing assay is used to determine whether or not a cytosine is methylated
What type of gel system can be used to enumerate the number of acetlyated lysines on a histone protein?
Name two classic endocrine receptors
What is the ATPase subunit of the Rsc chromatin remodeling complex?
Enzymes that catalyze the acetylation of histones are called
CpG ___ are usually found near ___ and will remain unmethylated
___ contain de-capping enzymes, while ___ do not
(T/F): H3K6 methylation is more complex in plants than fungi/animals
As yeast age, circular fragments of ___ accumulate. This can be blocked by increased ___ gene expression
What enzyme processes pre-miRNA to a stem loop?
DCP2 is the
Which X chromosome in females is highly acetlyated?
Which chromatin is more transcriptionally active, euchromatin or heterochromatin?
Mutations in the ___ genes can suppress mating switch mutations in yeast.
Gal4 can bind nucleosome DNA once ___ has lifted its DBD off the nucleosome surface
Polycomb group genes ___ gene silencing
The ___ domain is found in many proteins associated with HMTs

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