Science Quiz / MCB 5217 Final

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Can you name the MCB Term?

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Which Ago protein will cleave target mRNA if a perfect match with the miRNA is formed?
What type of phosphodiester bond is found in an mRNA cap?
Showing that the yeast ___ coactivator protein was a HAT provided evidence that acetylation was required for gene ___
What does SILAC stand for?
Which class of HDACs does TSA inhibit?
Class ___ HDACs were identified as art of the aging pathway
__ is used to determine rotational phasing, while ___ is used to determine translational phasing
The GCN5 coactivator in the cell is part of a large complex called the ___complex
During myogenesis, class II HDACs regulate the activity of the ___ TF
Methylation at H3K__ is associated with gene silencing, whereas H3K__ methylation is associated with gene expression
Class I HDACs are frequently overexpressed in ___ cells
Mutations in the ___ genes can suppress mating switch mutations in yeast.
What type of sequnece keeps some DNA from becoming methylated?
What percentage of mRNAs can be regulated by an miRNA?
Prognosis for cancer patient with low HDAC activty:
DCP2 is the
Which type of miRNA gene targeting is most common in mammals? Degradation or inhibition?
In SILAC, proteins are distinguished by ___ due to the incorporation of ___
The histone ____tetramer forms the center of the nucleosome
SWI/SNF complex uses ___ to travel down the ___ molecule
The TRX group proteins silence genes by methylaing promoter-associated nucleosomes at ___
Which DNMT is a de novo DNA methyltransferase?
Drosha is located in the ___
HATs acetylate the ____
___ describes the position of the octomers
(T/F): SWI mutations only affect mating type and have no other defects.
___ contain de-capping enzymes, while ___ do not
Which DNMT is a maintenence DNA methyltransferase?
mRNA facilitates ___ recycling and makes ___ more efficient
For transcription in vitro, what must be added first, TFs or nculeosome?
The ___ domain is found in many proteins associated with HMTs
Which tetrahymena nucleus is highly aceylated?
CpG ___ are usually found near ___ and will remain unmethylated
Gal4 can bind nucleosome DNA once ___ has lifted its DBD off the nucleosome surface
Which HMT methylates histone H3K27
2 mRNA molecules with AU-rich elements in their 3' UTR:
___ is an endonuclease that cleaves linker DNA
What are the four human chromatin-remodeling machines?
Which HMT methylates histone H3K4?
What type of gel system can be used to enumerate the number of acetlyated lysines on a histone protein?
What enzyme processes a stem loop RNA into an miRNA?
Which groove does DNAse I cut?
MLL/SET I acetylates H3K_ and associates with the ____
What was the first HAT to be identified? What species was it from?
The ___ sequencing assay is used to determine whether or not a cytosine is methylated
SWI mutants cannot switch their mating type because they can't activate expression of the ___ gene
mRNA will form a ___ to interact so proteins can bind to the ___ and ___
Polycomb group genes ___ gene silencing
Which X chromosome in females is highly acetlyated?
Two proteins which bind HP1:
Purified GCN5 can acetylate ___ but must be in a ___ complex to acetylate nucleosomes
Trithorax group genes ___ gene silencing
Name two classic endocrine receptors
The ___ group gene products are chromatin associated proteins required for repression of clustered homeotic genes
Where on mRNA do miRNAs usually bind
An ammended SILAC method:
A stress granule stores ___ and prevents it from being ___
Which chromatin is more transcriptionally active, euchromatin or heterochromatin?
Which HMT methylates histone H3K9
Do GCN4 and GCN5 both contain a DBD?
mRNA circularization offcurs as the result of an interaction between two proteins:
mRNA circularizes when 5' and 3' ends interact. This is thought to promote ____ and increased translation efficiency
List 5 elements of mRNA structure
Which histone methylation is found in pericentromeric DNA?
Class III HDACs like Sir2 require ___ to deacetylate histones
What enzyme processes pre-miRNA to a stem loop?
List the Class I HDACS (1-8)
Enzymes that catalyze the acetylation of histones are called
(T/F): H3K6 methylation is more complex in plants than fungi/animals
DNA with a high density of CpGs is associated with the decreased ___ of cytosines
The miRNA strand chosen to target an mRNA has __ base pairing at the 5' end.
What does bisulfite convert unmethylated cytosine to?
How many bp are assosciated with a nucleosome?
How many times does DNA wrap around the nucleosome?
Are most CpG dinucleotides methylated?
The SAGA complex forms a bridge between ___ proteins and proteins in the ___
The basic repeating structural unit of chromatin is the ___ which contains __ histone proteins present at __ copies
___ can be used to determine which groove of the DNA is facing the nucleosome
Rather than removing the nucleosome from DNA, SWI/SNF alters the ____ of DNA on the nucleosome
The ___ mutants do not allow haploid yeast to switch mating types.
What is the ATPase subunit of the Rsc chromatin remodeling complex?
Class II HDACs can shuttle from the ___ to the ___
p15 ___ RNA silences the ___ in tumors
Where does the acetyl group for histone acetylation come from?
Where does the methyl group for histone methylation come from?
As yeast age, circular fragments of ___ accumulate. This can be blocked by increased ___ gene expression
What DNA sequence is methylated in mammals?
List 2 HDAC inhibitors

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