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cell
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Regeneration & iPS Cells Stats
Can you name the Regeneration & iPS Cells?
By
EffDevBio
15m
50 Questions
4 Plays
4 Plays
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Timer
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Hint
Answer
% Correct
regrowth of amputated body parts of nonfunctioning organs
regeneration
100%
regeneration requires the _
_
_
_
_
_
_
of the tissue
de novo patterning
25%
replacement of singular tissue type
repair
25%
repatterning of existing tissue with little new growth
morphallaxis
25%
dedifferentiation of adult tissues that forms an undifferentiated cell mass that ultimately becomes respecified
epimorphosis
25%
differentiated cells divide while maintaining their differentiated functions
compensatory regeneration
25%
tissue-
specific adult stem cells serve as source of cells for regrowth
stem-cell mediated regeneration
25%
head generator
hypostome
25%
tail/
foot generator
basal disc
25%
adult muscle stem cells
satellite cells
25%
Is cell division required in morphallactic regeneration?
No
25%
direct specific regeneration
morphogens
25%
This gene is a hypostome/
apical hydra morphogen
Wnt
25%
This gene is a basal/
foot hydra morphogen
Shin-guard
25%
best studied example of epimorphosis
salamanders
25%
True or false: all of the different cell types are present in the new limb formed by epimorphosis?
True
25%
Regeneration in amphibians involves formation of a _
_
_
_
_
by epimorphosis
blastema
25%
ability to regenerate by epimorphosis is dependent on cells retaining ability to
re-enter cell cycle
25%
proliferation of epidermal cells adjacent to stump will lead to
apical ectodermal cap
25%
these degenerate at the site of amputation
nerves
25%
transcription decreases in these differentiation genes during epimorphosis
myf5, myoD
25%
transcription increases in these mesenchyme proliferating genes during epimorphosis
msx1
25%
these cells redifferentiate to form the new structures of the limb
blastema
25%
this shares similarities to limb regeneration
limb bud development
25%
the regeneration blastema is analogous to the _
_
_
_
_
in limb bud development
progress zone
25%
Hint
Answer
% Correct
limb regeneration is dependent on interaction between _
_
_
& _
_
_
mesenchyme, ectoderm
25%
These patterning signals control limb regeneration and limb bud development
FGF8 in AER, Shh in ZPA, Wnt7a in dorsal limb
25%
the first step of blastema growth is dependent on
nerve
25%
proliferation in the first step of blastema growth is dependent on
innervation
25%
nerves produce these factors
GGF, FGF2
25%
the second step of blastema growth is dependent on
mesenchyme
25%
proliferation in the second step of blastema growth is dependent on expression of
FGF10
25%
expression of _
_
_
_
induces expression of _
_
_
_
in the overlying ectoderm
FGF10, FGF8
25%
regeneration of newt limbs depends on this protein supplied by limb nerves
nag
25%
during epimorphic regeneration, the structure formed by dedifferentiating tissues is
blastema
25%
a good example of compensatory regeneration lies in the
liver
25%
in zebrafish, differentiated cardiomyocytes are still _
_
_
_
_
_
that can proliferate to form new heart muscle
single cells
25%
in mammals there appears to be a neonatal _
_
_
_
_
_
for regenerative potential
time window
25%
lizards can regenerate
spinal cord, articular cartilage, muscle groups
25%
lizard vertebrae have _
_
_
_
_
break points
autonomous
25%
True or false: Regenerated tail inside is structurally identical to original tail
false
25%
data suggests lizards regenerate by this mechanism
stem cell-mediated regeneration
25%
site of bone stem cells
osteoblasts
25%
site of neuron stem cells
neural stem cells
25%
site of blood cell, dendritic cell, osteoclast stem cells
hematopoietic cells
25%
an example of multi-
potential stem cells are
mesenchymal stem cells
25%
25%
4 Mechanisms of regeneration
morphallaxis, epimorphosis, compensatory regeneration, stem-cell mediated
0%
these cells migrate under the AEC to form the regeneration blastema
bone, cartilage, myocytes, neurons
0%
The 4 iPS genes
Oct4, c-myc, Klf4, Sox2
0%
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