Dick Richard, replaced by Steven Spielberg for (among other reasons) constantly referring to the shark as a whale.
George Cukor, replaced by Victor Fleming due to too slow a pace and rumored disagreements with Clark Gable.
Phil Lord & Chris Miller, replaced by Ron Howard who ended up reshooting up to 70% of the film.
Richard Stanley, replaced by John Frankenheimer after the former was unable to work with Val Kilmer and the producers sided with Kilmer.
Anthony Mann, replaced by Stanley Kubrick after several weeks of filming in what would be Kubrick's only film without complete directorial control.
Tony Kaye, replaced by star Edward Norton in the editing room after Kaye's original cut was deemed unacceptable.
Steven Soderbergh, replaced by Bennett Miller after Soderbergh's script revisions were deemed too artsy and inside-baseball.
Brenda Chapman, replaced by Mark Andrews after creative differences with Pixar heavyweight John Lasseter.
Bryan Singer, replaced by Dexter Fletcher with two weeks left of filming after erratic behavior and clashes with star Rami Malek.
Kevin Reynolds, replaced for the last few weeks of filming by star Kevin Costner after the first Kevin walked off the set.
Colin Trevorrow, replaced by J.J. Abrams due to creative disagreements with producer Kathleen Kennedy.
Philip Kaufman, replaced by star Clint Eastwood after the two differed on the revisionist tone of the Western.
Richard Thorpe, replaced by George Cukor and then Victor Fleming after it was felt Thorpe was rushing production to the detriment of Judy Garland.
Paul Schrader, replaced by Renny Harlin after his horror was more psychological than graphic. Schrader's cut was released as 'Dominion.'
Ted Griffin, replaced by Rob Reiner after falling behind schedule; Aniston stayed but several major roles were recast.
John McTiernan, replaced by source novel author Michael Crichton after poor audience test reaction to the original cut.
Richard Donner, replaced by Richard Lester with more than 75% in the can. Lester finished it (with filming occuring at times two years later) and reshot other scenes.
Martin Brest, replaced by John Badham after Brest's vision was too dark for the studio, who wanted Broderick and Sheedy to be more exciting and less brooding.
Kevin Jarre, replaced officially by George Cosmatos after being overwhelmed, but the real person in the director's chair was star Kurt Russell.
Josh Trank, replaced in post-production by editor Stephen Rivkin after Trank's unpredictable behavior, odd directorial choices, and morose tone proved too much for Fox.
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