Science Quiz / Drugs MVST IB - part 1

Random Science Quiz

Can you name the drugs from MVST IB - part 1?

Quiz not verified by Sporcle

Forced Order
Score 0/156 Timer 20:00
DescriptionDrug nameUse
Indirectly acting sympathomimetic amine - converted to octopamine by DBH - found in various foodstuffs
Competitive inhibitor of tyrosine hydroxylase
Selective beta-1 antagonist (slight effect on beta-2)
Inodilator used to treat canine dilated cardiomyopathy - calcium sensitiser
Blocks transport of adenosine into cells - phosphodiesterase type V inhibitor
Immunosuppressant drug with antiproliferative effects
Inhibits platelet activation by inhibiting binding of ADP to its receptor on platelets
Orally-acting hypoglycaemic agent - sulphonylurea
Plasminogen + anisoylated streptokinase
Calcium sensitiser - increases cardiac Ca2+ binding efficiency to troponin - inhibits phosphodiesterase III
Reversible anticholinesterase - ionic interaction
Depolarising blocker at NMJ
Arteriolar vasodilator - unknown mechanism
Selective antagonist for M3 muscarinic receptor
Indirectly-acting sympathomimetic amine - weak inhibitor of MAO
Experimental cardiac glycoside
Use-dependent block of ganglionic transmission
Carbonic anhydrase inhibitor
Selective non-depolarising neuromuscular blocking agent at NMJ - long action, not hydrolysed
Phosphodiesterase III inhibitor - inodilator
Slightly selective alpha-2 agonist (also alpha-1 actions) - omitting dose can lead to rebound hypertension
Tyrosine kinase inhibitor
Irreversibly alkylates muscarinic receptor
Selective alpha-2 antagonist (slight effect on alpha-1)
Alpha-2 antagonist (some effect on alpha-1)
Nitrovasodilator - produces NO - metabolised in liver to active drug
COMT inhibitor
Progestagen receptor antagonist
Quaternary local anaesthetic analogue - only effective if perfused inside cells
Regulates expression of multiple angiogenic genes
Glucocorticoid receptor antagonist
A1 receptor antagonist - non-selective phosphodiesterase inhibitor
Non-selective, reversible MAO inhibitor
Intracellular tetravalent polyamine - helps produce inward rectification of K+ channels
Blocks Na channels from exterior - no use-dependence
Single chain recombinant human tissue plasminogen activator
Non-peptide inhibitor of glycoprotein IIb/IIIa receptor
Acts on imidazoline receptors
NSAID used to prevent thrombosis
Cholinergic agonist - not selective between nicotinic/muscarinic receptors
Estrogen receptor agonist
Interferes with normal function of microtubule growth
K channel opener
Competitively inhibits plasminogen activation - inhibits severe bleeding from excessive clot lysis
Anion exchange resin - prevents reuptake of bile acids from intestine
ACE inhibitor - prodrug, must be metabolised in liver
Glucocorticoid receptor agonist
Nicotinic receptor antagonist - relatively non-selective between NMJ and ganglion at clinical doses
Non-selective alpha-adrenoceptor antagonist
Non-peptide angiotensin II antagonist - acts on AT1 receptors
Class III antidysrhythmic - prolongs AP and refractory period
Calcium channel antagonist - dihydropyridine - affects L-type but not T-type channels
DescriptionDrug nameUse
Tricyclic antidepressant - blocks NET
Illegal drug - blocks NET
Beta-1 agonist - weak beta-2 agonist
Blocks release of neurotransmitter via phospholipase A2 - localises to membrane by K channel binding moiety
Mineralocorticoid receptor antagonist - potassium-sparing diuretic
Very potent alpha-2 agonist
Inhibits intestinal absorption of cholesterol - circulates enterohepatically
Calcium channel blocker - phenylalkylamine - class IV antidysrhythmic
Nitrovasodilator - produces NO
NOS inhibitor - not very selective for different forms
Phosphodiesterase III inhibitor - inodilator
Double chain recombinant human tissue plasminogen activator
ACE inhibitor
ADP-ribosylates alpha-s - inhibits GTPase activity - sustained activation of adenylyl cyclase
Local anaesthetic - slow onset/offset - use dependence at low rates of stimulation - class IA antidysrhythmic
Selective antagonist for M1 muscarinic receptors
Co-released with NA or ACh - acts on purinoceptors (P2 > P1)
Combined alpha- and beta-adrenoceptor antagonist
Inhibits liver triglyceride production and VLDL secretion - increases levels of tissue plasminogen activator
Non-selective phosphodiesterase inhibitor
K channel opener - also NO donor
SSRI - blocks 5-HT transporter in Uptake 1
Mineralocorticoid receptor agonist
Beta-1 antagonist used in heart failure
Acts on imidazoline receptors
Blocks If current in SA node
Progestagen receptor agonist
K channel opener
Cholinergic agonist - +-isomer hydrolysed by AChE
Irreversible alpha-adrenoceptor antagonist - blocks Uptake 2 (and Uptake 1 at 10x higher concs)
Non-selective phosphodiesterase inhibitor
Selective non-depolarising neuromuscular blocker at NMJ - ester, broken down by spontaneous hydrolysis and plasma esterases
Nitrovasodilator - produces NO - taken sublingually
Inhibits DOPA decarboxylase in periphery
Local anaesthetic - weak base - use-dependence and voltage-dependence
Lowers VLDL (and LDL) by stimulating lipoprotein lipase - may activate PPARs
Binds to synaptobrevin to prevent vesicle release from inhibitory interneuron synapses with motor neurons
Selective alpha-1 agonist (some action on beta-1)
Competitively inhibits plasminogen activation - inhibits severe bleeding from excessive clot lysis
Converted to alpha-methylNA - released as false transmitter - more potent at alpha-2, less potent at alpha-1
Orally-acting hypoglycaemic agent - sulphonylurea
Calcium channel agonist - dihydropyridine
Binds to neurexins, causing massive ACh release from nerve terminals
Blocks transporter carrying ACh into storage vesicles
Competitive antagonist for ganglionic nicotinic receptor - inactive at NMJ
Involved with providing new blood flow to ischaemic tissues
alpha-1 antagonist most commonly used
Uncompetitive inhibitor of phosphatase acting on IP1 --> inositol
ADP-ribosylates alpha-i - prevents activation of Gi in response to stimulation
Thiazide diuretic - blocks Na/Cl transport in early distal tubule
Osmotic diuretic - filtered at glomerulus, not reabsorbed
Selective alpha-2 agonist
DescriptionDrug nameUse
Partial agonist at alpha-adrenoceptors - 5-HT agonist
Direct acting vasodilator - metabolised to NO or cyanide
Muscarinic receptor agonist
Non-selective beta-adrenoceptor antagonist
Local anaesthetic (ester, weak base) - broken down by BuChE
Selective MAO-A inhibitor
Muscarinic receptor antagonist - very long duration of action
Blocks release of NA evoked by APs (repeated low doses/aftermath of large dose) - indirect sympathomimetic actions (large doses)
Beta-adrenoceptor agonist
Depolarising blocker selective for ganglion nicotinic receptor
Irreversible anticholinesterase - organophosphorus agent
Inhibits clotting by inhibiting synthesis of factors II, VII, IX, IX and regulatory proteins C, S, Z
Non-selective agonist for muscarnic receptors
Irreversible anticholinesterase - activated by replacement of sulphur atom with oxygen, deoxified by plasma carboxylesterases
Binds very tightly to VMAT-2, preventing loading of catecholamines into vesicles
Used experimentally to inhibit dopamine beta-hydroxylase - also inhibits aldehyde dehyddrogenase
Irreversible antagonist at nicotinic NMJ receptors (no effect on ganglionic receptors)
Beta-1 antagonist used in heart failure
Selective beta-2 antagonist (slight effect on beta-1)
Selective inhibitor of phosphodiesterase type V (selectively breaks down cGMP)
Depolarising blocker selective for NMJ nicotinic receptor - very short duration of action, broken down by BuChe - deficiency in enzyme activity can lead to prolonged action
Selective beta-2 agonist (slight effect on beta-1)
Local anaesthetic - uncharged
Blocks uptake of choline into neurons
Class IC antidysrhythmic
Tricyclic antidepressant - blocks NET
Monoclonal antibody against glycoprotein IIb/IIIa receptor - prevents platelet aggregation - also binds to vitronectin receptor
Non-selective agonist for muscarinic receptors
Potent, irreversible inhibitor of iNOS in activated macrophages
Loop diuretic - blocks Na/K/2Cl transport in thick ascending limb
Reverse inhibition of AChE by organophosphorus agents
Selective alpha-1 antagonist (slight effect on alpha-2)
Inhibits HMG-CoA reductase - also many pleiotropic effects
Binds to plasminogen activator, increasing generation of plasmin
Medium 'reversible' anticholinesterase - binds to esteratic site and carbamoylates ACh
Selective MAO-B inhibitor
Potassium-sparing diuretic - blocks apical Na+ channels in late distal tubule
Non-specific endothelin receptor antagonist
K channel opener - also hirsutism effects
Estrogen receptor antagonist
PPAR-gamma agonist
Competitive antagonist for ganglionic nicotinic receptors - inactive at NMJ
Binds to SNAREs involved in membrane fusion, preventing ACh release
Calcium channel blocker - benzothiazepine
Selective inhibitor of NOS in neurons
Causes development of new blood vessels
Potassium-sparing diuretic - blocks apical Na+ channels in late distal tubule
Mild partial beta-1 agonist
Angiotensin II partial agonist
Naturally occurring anticoagulant produced by basophils/mast cells - exposes active site of antithrombin III
Cardiac glycoside - inhibits Na/K-ATPase
Cyclic heptapeptide inhibitor of glycoprotein IIb/IIIa receptor

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Sign Up with Email
Log In

You Might Also Like...

Show Comments


Top Quizzes Today

Score Distribution

Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.