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Can you name the More Viruses?

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Score 0/63 Timer 15:00
HintVirusExtra
sGP with immunomodulatory functionAlso reduces antibody count
ZoonoticHarder to eliminate, less herd immunity
Soluble IFNa/b binding proteins
Block transport of peptides into ERDecreases CTL action
3.2kb genome4 reading frames
Cancer - Kaposi's sarcoma
High frequency genetic recombination
Binds to sialic acid with HAHA is a trimer
Lacks env proteinRequires co-infection with helper, src instead
MHC - proteolytic degradationRemains largely cell-associated (like measles)
Soluble cytokine receptors
Prevent activation of PRR cascadeDecreases IFN gamma
Virus clearance requires seroconversion
Bullet-shaped
Hep - Drugs>Vaccine
Antigenic shift and drift
Cancer - nasopharyngeal
Temporally distinct gene classesPox - early, intermediate, late
Latency
VG35 Inhibits IRF3 and binds dsRNADecreases IFNa/b release
Very stable outside the host
HintVirusExtra
DNA with Virion transcriptaseTranscription of viral promoters
10^6 mutant viruses produced/day
Surface glycoprotein HBsAgNeutralises antibodies
NS2/NS3 proteases
Cytopathic effect
Entry uses E1 and E2
Cancer - Burkitt lymphoma
Acute and chronic hepatitis
Cancer - cervical or penile
Expressed viral IL-10
Retains MHC intracellularlyMay result in NK missing self
Capsid (p24) with envelope (gp41, gp120)Gp120 binds CD4 and CCR5/CXCR4
Shed in concs of 10^9 pfu/ml
Down-regulate CD4 and inhibit NFkBVpu and Vpr proteins
Incubation, pre-haemorrhagic and haemorrhagic
Resistant to low pH and protease
Expressed EGF to improve adjacent cellsInduces hypoxic response - biochem reactions
Soluble cytokine receptors
Cleave mRNA caps
Asymptomatic for ~10 years
Enters by gp340 binding to CD21
HintVirusExtra
Stimulate cell into cell cycle
Capsid assembles spontaneouslyHelical capsid
VP24 blocks STAT1 entering nucleusBinds nuclear pore proteins
Systemic infection
NS2 induces change in gene expression
Hep - Vaccine>Drugs
Proteins produced from one reading frameLater polyprotein processing
Inhibit ISG proteinsPKR, OAS
Inhibits JAK-STAT pathway
Infects liver macrophages (Kupffer)
Cancer - hepatocellular
Carried by biting insects
Dane particles (42nm) and lipoproteins (22nm)
Buds through cell membrane
Produce dNTPs
Destroys ribosome cap-binding complexShuts off host protein synthesis in an hour (IRES)
Gag, pol and envGag 1st, Pol frameshift, Env splicing
Acute hepatitis
Infects cerebellar Purkinje cells
Virions formed by internal budding into ER
Can grow in macrophages

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