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Can you name the More Viruses?

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Score 0/63 Timer 15:00
HintVirusExtra
Virions formed by internal budding into ER
Resistant to low pH and protease
Cancer - Burkitt lymphoma
Soluble IFNa/b binding proteins
ZoonoticHarder to eliminate, less herd immunity
NS2 induces change in gene expression
Virus clearance requires seroconversion
VP24 blocks STAT1 entering nucleusBinds nuclear pore proteins
Shed in concs of 10^9 pfu/ml
10^6 mutant viruses produced/day
Capsid (p24) with envelope (gp41, gp120)Gp120 binds CD4 and CCR5/CXCR4
Infects liver macrophages (Kupffer)
Can grow in macrophages
Cancer - Kaposi's sarcoma
Inhibit ISG proteinsPKR, OAS
Down-regulate CD4 and inhibit NFkBVpu and Vpr proteins
Expressed viral IL-10
VG35 Inhibits IRF3 and binds dsRNADecreases IFNa/b release
Soluble cytokine receptors
Antigenic shift and drift
sGP with immunomodulatory functionAlso reduces antibody count
HintVirusExtra
Stimulate cell into cell cycle
Expressed EGF to improve adjacent cellsInduces hypoxic response - biochem reactions
Latency
Lacks env proteinRequires co-infection with helper, src instead
Block transport of peptides into ERDecreases CTL action
Destroys ribosome cap-binding complexShuts off host protein synthesis in an hour (IRES)
Systemic infection
Carried by biting insects
Proteins produced from one reading frameLater polyprotein processing
Hep - Drugs>Vaccine
NS2/NS3 proteases
Retains MHC intracellularlyMay result in NK missing self
Acute and chronic hepatitis
Cytopathic effect
Inhibits JAK-STAT pathway
Cancer - hepatocellular
Prevent activation of PRR cascadeDecreases IFN gamma
Entry uses E1 and E2
Asymptomatic for ~10 years
High frequency genetic recombination
Buds through cell membrane
HintVirusExtra
Capsid assembles spontaneouslyHelical capsid
3.2kb genome4 reading frames
Cancer - cervical or penile
Incubation, pre-haemorrhagic and haemorrhagic
Acute hepatitis
Enters by gp340 binding to CD21
Hep - Vaccine>Drugs
Gag, pol and envGag 1st, Pol frameshift, Env splicing
Dane particles (42nm) and lipoproteins (22nm)
Infects cerebellar Purkinje cells
DNA with Virion transcriptaseTranscription of viral promoters
Bullet-shaped
Cancer - nasopharyngeal
Produce dNTPs
Soluble cytokine receptors
Temporally distinct gene classesPox - early, intermediate, late
MHC - proteolytic degradationRemains largely cell-associated (like measles)
Cleave mRNA caps
Very stable outside the host
Binds to sialic acid with HAHA is a trimer
Surface glycoprotein HBsAgNeutralises antibodies

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