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Can you name the More Viruses?

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HintVirusExtra
NS2/NS3 proteases
Very stable outside the host
Infects liver macrophages (Kupffer)
Proteins produced from one reading frameLater polyprotein processing
Prevent activation of PRR cascadeDecreases IFN gamma
Inhibits JAK-STAT pathway
Soluble cytokine receptors
Produce dNTPs
Capsid assembles spontaneouslyHelical capsid
Cancer - nasopharyngeal
Latency
ZoonoticHarder to eliminate, less herd immunity
Binds to sialic acid with HAHA is a trimer
Lacks env proteinRequires co-infection with helper, src instead
Entry uses E1 and E2
Acute hepatitis
Buds through cell membrane
Expressed viral IL-10
sGP with immunomodulatory functionAlso reduces antibody count
Can grow in macrophages
Down-regulate CD4 and inhibit NFkBVpu and Vpr proteins
HintVirusExtra
Systemic infection
Block transport of peptides into ERDecreases CTL action
Shed in concs of 10^9 pfu/ml
Hep - Drugs>Vaccine
VG35 Inhibits IRF3 and binds dsRNADecreases IFNa/b release
Soluble cytokine receptors
Bullet-shaped
Inhibit ISG proteinsPKR, OAS
Infects cerebellar Purkinje cells
MHC - proteolytic degradationRemains largely cell-associated (like measles)
NS2 induces change in gene expression
Incubation, pre-haemorrhagic and haemorrhagic
Retains MHC intracellularlyMay result in NK missing self
VP24 blocks STAT1 entering nucleusBinds nuclear pore proteins
Destroys ribosome cap-binding complexShuts off host protein synthesis in an hour (IRES)
Temporally distinct gene classesPox - early, intermediate, late
Enters by gp340 binding to CD21
DNA with Virion transcriptaseTranscription of viral promoters
10^6 mutant viruses produced/day
Cancer - Kaposi's sarcoma
Antigenic shift and drift
HintVirusExtra
Virions formed by internal budding into ER
Cancer - hepatocellular
Acute and chronic hepatitis
Dane particles (42nm) and lipoproteins (22nm)
Hep - Vaccine>Drugs
Soluble IFNa/b binding proteins
Gag, pol and envGag 1st, Pol frameshift, Env splicing
Stimulate cell into cell cycle
3.2kb genome4 reading frames
High frequency genetic recombination
Virus clearance requires seroconversion
Asymptomatic for ~10 years
Expressed EGF to improve adjacent cellsInduces hypoxic response - biochem reactions
Resistant to low pH and protease
Cancer - cervical or penile
Surface glycoprotein HBsAgNeutralises antibodies
Cytopathic effect
Cleave mRNA caps
Carried by biting insects
Capsid (p24) with envelope (gp41, gp120)Gp120 binds CD4 and CCR5/CXCR4
Cancer - Burkitt lymphoma

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Extras

Created May 14, 2016ReportNominate
Tags:Extra, Virus

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