Science Quiz / Infectious Disease Block 6 - Fungus

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Can you name the Infectious Disease Block 6?

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QuestionAnswerAdditional information
Tx for Zygomycetes
Tx for histoplasmosis, spirotrichosis, and blastomyces. Taken with food/coca cola. Side effects: Adrenal excess (edema, hypertension, hypokalemia) nausea, vomiting. Long term - per
Strain of cryptococcus on the west coast and hits non-immuncompromised
Dose dependent Candida strain
candida strain resistant to azoles
prophylaxis for pneumocystis and toxoplasmosis
Parental drug addict mucormycosis
HIV, Thailand, Red pigment
right angle hyphae
Drug with multiple double bonds and intercalates into fungal plasma membranes creating lytic pores
Antifungal drug whose mechanism is similar to that of penicillin to bacteria. Tx for candida and aspergillus.
Rapid O2 desaturation upon exertion. Life threatening pneumonia in AIDS. Ubiquitous
Low Alkaline phosphatase, LDH less than 300, Leukocytopenia. Diagnosed via urine serology
Massive laryngeal mass causing obstruction - South americam agricultural worker
Treats ring worm and nail infections. Inhibits nucleic acid synthesis
Need to suppliment with potassium, magnesium and EPO because of its renal toxicity.
Side effects are: Shake and Bake (fever chills, headache, nausea, vomiting) mediated through release of prostaglandin E. Renal toxicity is closely watched.
Risk factor for yeast infection
When in serum grows pseudohyphae. Retinal presentations
DNA synthesis inhibitor. Goes to the CNS. Can Cause hemorrhagic colitis and pancytopenia
Dx stain for Cryto
Skinny white male with COPD gets this fungal infection. pneumoia pericarditis, adrenal disease, adenocarcinoma like bowel lesions
Serology is great and should ALWAYS be followed
Never use this for diagnosis of cryptococcus
Bone fungal infections
Arizona/mexico border, Confussion/meningitis
erythema nodosum, hilar adenopathy. Apical cavitary disease. Dark skin and pregnancy are risk factors. Meningitis = Tx for life
Drug addict, diabetic w/ ketoacidosis, Bone transplant recipient, Renal Failure. Black necrosis of the ororpharynx. Rapid presentation
QuestionAnswerAdditional information
Apical lung fungal ball
Verrucous/warty skin lesions in cooler areas (tip of nose, fingers)
Narrow base budding
Fungal infection causing baldness
Jock Rot 'well demarcated line'
Ring worm
Ubiquitous with hyphae branching at acute angles
Drug that is concentrated in the skin. Side effect is a loss of taste. Effective against dimorphic fungi in nails and skin
Serology is terrible and is often false positive for histoplasmosis
Bind to fungal heme iron in cytochrome P-450
diaper rash
Tx for cryptococcus meningitis (Abv.)
Halo sign, wedge shaped pulmonary emboli infarct, immune compromised
Diabetic mucormycosis
Strain of cryptococcus that hits immunecompromised
Broad base budding, In soil. Great lakes. Beavers. Hits Normal immune systems. Fisherman, campers, hunters
Immunecompromised w/ old dressings or IVs mucormycosis
Antifungal to treat fungal UTI's and has CSF penetration. Great pharmacokinetics.Treats coccidioides.
Athletes foot
Bone marrow recipients/leukemic pts. mucormycosis
Pseudo membrane in oropharynx - thrush.
Fungal infection that runs along lymphatic vessel. Rose growers disease
Anti-fungal with Side effects of adrenal Insufficiency and hepatic necrosis. Needs gastric acid for absorption
HIV Finger nail infection
MCC of fungal meningitis in AIDS pts. Pidgeon poop.
Distal finger nail infection
Intracellular fungus, Spelunking, prisons, chicken coops
Anti-fungal with 3 fluorides. Tx for aspergillus. S/E - Bone pain, alteration in electroretinogram, increased alkaline phos, periostitis, Visual scatoma. Multiple drug interactions

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