Miscellaneous Quiz / Thera2-DyslipidemiaDrugs

Random Miscellaneous Quiz
Score 0/130 Timer 20:00
T or F: When on statin therapy, the appropriate action to take if there are muscle Sxs + CK elevation > 10x ULN is to: D/C statin - follow CK weekly.
Brand Name Colesevelam
T or F: Ezetimibe should be used in caution in renal or hepatic impairment and are not recommended in moderate or severe hepatic impairment.
Fluvastatin 20mg lowers LDL by ___%
BAS are contraindicated in dysbeta-lipoproteinemia and TG > ____ mg/dL.
Verapamil, Cyclosporine, Protease Inhibitors, and Diltiazem's mechanism of interaction with statins is CYP____ inhibition.
T or F: Patient education for Omega-3 fatty acids includes taking it immediately prior to meals to decrease fishy taste.
Lowest dose of Simvastatin: ___mg
Omega-3 Fatty acid starting dose is: ___ g daily, which may then be increased to 4 grams daily with meals.
Lowest dose of Pravastatin: ___mg
T or F: CYP450 drug interactions are NOT a risk factor for myopathy because they result in increased statin concentration
T or F: XR Niacin has more hepatotoxicity and SR Niacin.
Which of the following statins is NOT metabolized by CYP3A4: (a) Simvastatin (b) Pravastatin (c) Lovastatin (d) Atorvastatin?
Fibric acid derivatives' MOA is increasing the functional activity of _______ ________.
T or F: the MOA of ezetimibe inhibits absorption of dietary and biliary cholesterol by blocking transport at the brush boarder of the small intestine.
T or F: Bile Acid Sequestrant's mechanism of action with statins is intestinal drug binding resulting in INCREASED statin bioavailability.
T or F: Slo-Niacin is available as an OTC dietary supplement.
Term for 'muscle aches or weakness without CK (creatinine kinase) elevation.'
T or F: Statins are the most effective LDL lowering drugs and are therefore considered first line agents for LDL lowering.
T or F: Gemfibrozil has greater inhibition of glucuronidation than fenofibrate.
T or F: Patient education for BAS includes: mixing powders with water, juice, or noncarbonated beverages; take with meals; do not hold in mouth or sip for prolonged periods; refrig
Niacin's mechanism of interaction with statins is: _______ effects
Which statin is most lipophilic and therefore most likely to cause myopathies?
Brand Name Pitavastatin
Brand Name Ezetimibe
Adverse effects of Omega-3 Fatty acids include: dyspepsia, nausea, fishy taste or 'fishy burp', ____ in INR in patients on warfarin with high doses (4g)
T or F: When on statin therapy, the appropriate action to take if there's muscle Sxs + moderate CK elevation (3-10 x ULN) is to: continue statin - follow CK weekly until Sxs resolv
Niacin accomplishes which of the following: (a) reduces hepatic synthesis of TG and secretion or VLDL (b) inhibits the conversion of VLDL into LDL - increased HDL (c) inhibit mobil
Which statin is the least potent in terms of % Reduction in LDL?
Fibric acid derivatives require ____ monitoring every 3 months for the first year, then periodically.
Brand Name Fenofibrate
Fibric acid derivatives may _______ ezetimibe's bioavailability.
Brand Name long-acting (sustained-release) Niacin
What statin is the most potent in terms of % reduction of LDL?
Statin monitoring: Muscle soreness, tenderness, or pain's follow-up schedule includes - baseline, __-12 weeks after initiation of therapy, and each follow-up visit.
Which drug class is pregnancy category X?
T or F: Other adverse effects of statins include: elevated hepatic transaminases, GI disturbance, headache, and rash.
The max dose per day of Slo-Niacin is: ___g/day.
Simvastatin 5mg lowers LDL by ___%
T or F: Gemfibrozil should be given 30 minutes prior to meals.
Rosuvastatin 5mg lowers LDL by ___%
Atorvastatin 10mg lowers LDL by ___%
T or F: Contraindications to statin use include active or chronic liver disease, concomitant use of interacting drugs, and pregnancy.
Patient education for statin's includes take at _______ and report any muscle pain/weakness, or brown urine.
T or F: The combination of Fibric Acid derivatives and statins decreases the risk for myopathy.
An example of a cholesterol absorption inhibitor is: ________.
Brand Name for Omega-3 Fatty Acid
Pravastatin 10mg lowers LDL by ___%
Fibric acid derivates' place in therapy is first line for increased ____ and as additional therapy to statins.
Adverse effects of BAS include: GI distress, constipation, decreased absorption of other drugs and a 5-10% increase in _______.
Lowest dose of Rosuvastatin: ___mg
Brand Name Gemfibrozil
Slo-Niacin's dosing: Initiate ____-500mg/day, titrate slowly.
Fibric acid contraindications include: severe ______ or hepatic disease.
Gemfibrozil normal dosing is ____mg BID
Fenofibrate has shown reduced risk of ___ events in diabetic and nondiabetic populations.
Brand Name Immediate Release Niacin
T or F: Statin dosing can be determined using the '6% Rule.'
T or F: When on statin therapy, the appropriate action to take if LFT elevates > 3x ULN is to: retest (could be random), if persists, decrease statin dose and monitor (may continue
Brand Name Lovastatin
Brand Name Cholestyramine
The max dose per day of Niaspan is: ___g/day.
T or F: Regarding statins, the risk of myotoxicity is dose related.
T or F: Niacin SR is only available with a prescription.
Ezetimibes place in therapy is for additive ____ lowering in addition to statin.
Which statin undergoes glucuronidation/minimal CYP2C9?
Cyclosporine may _______ plasma concentrations of ezetimibe.
The starting doses for Fenofibrate are ___mg-145mg/day.
Brand Name Simvastatin
T or F: Regarding statin monitoring, CK's follow-up schedule includes - a baseline and as muscle symptoms develop.
T or F: Pharmacodynamic interactions with other myotoxic agents (i.e. fibrates or niacin) can result in additive effects.
T or F: It is advised when using niacin, to avoid switching formulations.
Niacor dosing: Initiate 50-___mg BID-TID; titrate slowly over 2-3 weeks to achieve goal dose.
Statin monitoring: ALT and AST follow-up includes - a baseline, __ weeks after initiation of therapy, then annually (more frequently if indicated).
T or F: Bile acid sequestrants do NOT interfere with ezetimibe's absorption.
Lowest dose of Lovastatin: ___mg
T or F: When on statin therapy, the appropriate action if there's myopathy Sxs with no CK elevation is to: rule out other causes and monitor, may continue statin.
Contraindications for Niacin therapy include: chronic liver disease, severe gout, PUD, and _______.
Niacin extended release has increased chance of the patient experiencing _______.
Term for 'muscle symptoms with increased creatinine kinase (CK) levels.'
Amiodarone's mechanism of interaction with statins is CYP2C9 and CYP____ inhibition.
Brand Name Pravastatin
T or F: When on statin therapy, the appropriate action to take if there's a modest baseline elevation (< 3x ULN) of LFTs is: perform close follow-ups, but note there is no contrain
Niacin immediate release has increased chance of the patient experiencing _______.
Brand Name Extended Release Niacin
Term for 'muscle symptoms with marked creatinine kinase elevation (> 10x ULN) and creatinine elevation (damage to kidneys).'
Atorvastatin Brand Name
T or F: Equivalent doses of one niacin product may be substituted for another.
Ezetimibe dosing is ___mg PO daily - with or without food.
Which of the following is not an adverse effect of Niacin: (a) flushing (b) myopathies (c) hyperglycemia (d) hyperuricemia (e) hepatotoxicity (f) GI upset (g) PUD
Brand Name Fluvastatin
BAS place in therapy is as an add-on therapy to statin (2nd or 3rd line agent) and ________.
Omega-3 Fatty acids should be used as an adjunct to diet in patients with a very high TG (> or = ______mg/dL)
Lowest dose of Pitavastatin: ___mg
Grapefruit Juice's mechanism of interaction with statins is CYP_____ inhibition
T or F: Omega-3 fatty acids work because they are alternative substrates for TG synthesis and inhibit esterification of TG and other fatty acids.
Fibric Acid Derivative's mechanism of interaction with statins includes: additive effects and _________ inhibition (gemfibrozil).
T or F: An disadvantage of BAS is that they are systemically absorbed.
T or F: Statins decrease LDL receptor activity.
Niacin requires ___ monitoring.
The max dose of Fenofibrate is _____mg/day.
T or F: Bile Acid Sequestrants (BAS) MOA includes binding bile acid and preventing bile acid reabsorption.
Regarding 'statins' MOA, these drugs inhibit _____________, the enzyme that catalyzes the rate limiting step in cholesterol synthesis.
Niaspan dosing: Initiate ____mg HS x 1 month, then increase by _____mg/month until at desired dose
LFT monitoring for niacin therapy should be done: at initiation of therapy, every __-12 weeks for the 1st year, then periodically (1-2x per year).
T or F: Fenofibrate can be given without regard to meals
T or F: Statins increase clearance of LDL from blood.
Lovastatin 10mg lowers LDL by ___%
Which of the following are risk factors for myopathy? (a) female sex (b) older age (c) renal insufficiency (d) all of the above
Which of the following is NOT considered a 'pleiotropic effect' of statins: (a) improve endothelial functions, (b) plaque stabilization, (c) increase synthesis of HDL, or (d) decre
T or F: Niacin's place in therapy is for combined hyperlipidemias and as either an additional therapy to statin or as alternative to statin.
Tips to reduce flushing caused by niacin include: take with meal, take ____ 30 minutes prior to use, and avoid hot drinks, alcohol, or hot showers near dose.
For BAS, it's wise to advise the patient to take other medications __ hour prior or 4 hours after administration.
T or F: Statin monitoring parameters include: muscle soreness, tenderness, or pain; CK; and ALT, AST.
Clarithromycin and Erythromycin's mechanism of interaction with statins is: CYP_____ inhibition.
Adverse effects for fibric acid derivatives include: _________, N/V, skin rash, gallstones, and myopathy.
Pitavastatin 1mg lowers LDL by ___%
Which of the following statins should the patient be instructed to take at bedtime: (a) atorvastatin (b) pravastatin (c) rosuvastatin (d) simvastatin (e) pitavastatin.
Lowest dose of Fluvastatin: ___mg
Omega-3 Fatty Acids' place in therapy is for: ____________.
Brand Name Colestipol
Which of the following is NOT an adverse effect of ezetimibe: (a) nausea (b) diarrhea (c) flatulence (d) myalgia
T or F: Niacor's required multiple daily dosing may worsen compliance.
Brand Name Rosuvastatin
Niacor's usual dose is 1.5g - ___g/day.
An important point of patient education for Niacin is to instruct the patient to take it with _______.
T or F: Niacin's MOA is not completely understood, but it could be used as a primary agent since it does everything 'really well.'
Lowest dose of Atorvastatin: __mg
Ezetimibe may ________ the anticoagulant effect of warfarin.
Azole Antifungal's mechanism of interaction with statins is CYP3A4 inhibition, P-glycoprotein inhibition, and CYP____ (fluconazole).
Come Together.
Have Fun.
All Virtual.
We all need to come together. Play Sporcle's virtual live trivia to have fun, connect with people, and get your trivia on. Join a live hosted trivia game for your favorite pub trivia experience done virtually. If a virtual private party is more your thing, go here for details.

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Log In

Sporcle TV

Today on Sporcle TV

Watch our educational content, quiz creation guides, and fun videos on Sporcle TV.

Show Comments


Created Mar 5, 2011ReportNominate

Top Quizzes Today

Score Distribution

Paid Content

Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.

Report this User

Report this user for behavior that violates our Community Guidelines.