Miscellaneous Quiz / Thera2-DyslipidemiaDrugs

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Can you name the Thera2-DyslipidemiaDrugs?

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HintAnswer
Pitavastatin 1mg lowers LDL by ___%
T or F: The combination of Fibric Acid derivatives and statins decreases the risk for myopathy.
Tips to reduce flushing caused by niacin include: take with meal, take ____ 30 minutes prior to use, and avoid hot drinks, alcohol, or hot showers near dose.
Brand Name Immediate Release Niacin
T or F: Niacin SR is only available with a prescription.
Which of the following statins is NOT metabolized by CYP3A4: (a) Simvastatin (b) Pravastatin (c) Lovastatin (d) Atorvastatin?
T or F: Statins decrease LDL receptor activity.
Clarithromycin and Erythromycin's mechanism of interaction with statins is: CYP_____ inhibition.
The max dose per day of Slo-Niacin is: ___g/day.
Slo-Niacin's dosing: Initiate ____-500mg/day, titrate slowly.
T or F: the MOA of ezetimibe inhibits absorption of dietary and biliary cholesterol by blocking transport at the brush boarder of the small intestine.
T or F: Niacin's MOA is not completely understood, but it could be used as a primary agent since it does everything 'really well.'
T or F: Other adverse effects of statins include: elevated hepatic transaminases, GI disturbance, headache, and rash.
Lowest dose of Fluvastatin: ___mg
T or F: Equivalent doses of one niacin product may be substituted for another.
Niacin requires ___ monitoring.
Fibric acid derivates' place in therapy is first line for increased ____ and as additional therapy to statins.
For BAS, it's wise to advise the patient to take other medications __ hour prior or 4 hours after administration.
Which of the following is NOT considered a 'pleiotropic effect' of statins: (a) improve endothelial functions, (b) plaque stabilization, (c) increase synthesis of HDL, or (d) decre
Regarding 'statins' MOA, these drugs inhibit _____________, the enzyme that catalyzes the rate limiting step in cholesterol synthesis.
Niacin immediate release has increased chance of the patient experiencing _______.
Brand Name Colesevelam
T or F: When on statin therapy, the appropriate action to take if there's muscle Sxs + moderate CK elevation (3-10 x ULN) is to: continue statin - follow CK weekly until Sxs resolv
Brand Name Pitavastatin
T or F: Statin dosing can be determined using the '6% Rule.'
Ezetimibe may ________ the anticoagulant effect of warfarin.
T or F: Niacor's required multiple daily dosing may worsen compliance.
Brand Name Gemfibrozil
T or F: When on statin therapy, the appropriate action if there's myopathy Sxs with no CK elevation is to: rule out other causes and monitor, may continue statin.
Brand Name Colestipol
Brand Name Cholestyramine
Which of the following statins should the patient be instructed to take at bedtime: (a) atorvastatin (b) pravastatin (c) rosuvastatin (d) simvastatin (e) pitavastatin.
The starting doses for Fenofibrate are ___mg-145mg/day.
Which of the following is NOT an adverse effect of ezetimibe: (a) nausea (b) diarrhea (c) flatulence (d) myalgia
Niacin's mechanism of interaction with statins is: _______ effects
Niacor's usual dose is 1.5g - ___g/day.
Cyclosporine may _______ plasma concentrations of ezetimibe.
T or F: When on statin therapy, the appropriate action to take if LFT elevates > 3x ULN is to: retest (could be random), if persists, decrease statin dose and monitor (may continue
Lowest dose of Lovastatin: ___mg
Grapefruit Juice's mechanism of interaction with statins is CYP_____ inhibition
T or F: Omega-3 fatty acids work because they are alternative substrates for TG synthesis and inhibit esterification of TG and other fatty acids.
An example of a cholesterol absorption inhibitor is: ________.
Brand Name Fenofibrate
Amiodarone's mechanism of interaction with statins is CYP2C9 and CYP____ inhibition.
HintAnswer
Fibric acid contraindications include: severe ______ or hepatic disease.
T or F: An disadvantage of BAS is that they are systemically absorbed.
Which of the following is not an adverse effect of Niacin: (a) flushing (b) myopathies (c) hyperglycemia (d) hyperuricemia (e) hepatotoxicity (f) GI upset (g) PUD
Omega-3 Fatty acid starting dose is: ___ g daily, which may then be increased to 4 grams daily with meals.
T or F: Contraindications to statin use include active or chronic liver disease, concomitant use of interacting drugs, and pregnancy.
T or F: When on statin therapy, the appropriate action to take if there's a modest baseline elevation (< 3x ULN) of LFTs is: perform close follow-ups, but note there is no contrain
Brand Name Ezetimibe
Niacin extended release has increased chance of the patient experiencing _______.
T or F: XR Niacin has more hepatotoxicity and SR Niacin.
Fibric acid derivatives require ____ monitoring every 3 months for the first year, then periodically.
Lovastatin 10mg lowers LDL by ___%
T or F: Patient education for BAS includes: mixing powders with water, juice, or noncarbonated beverages; take with meals; do not hold in mouth or sip for prolonged periods; refrig
Azole Antifungal's mechanism of interaction with statins is CYP3A4 inhibition, P-glycoprotein inhibition, and CYP____ (fluconazole).
Lowest dose of Pravastatin: ___mg
Statin monitoring: ALT and AST follow-up includes - a baseline, __ weeks after initiation of therapy, then annually (more frequently if indicated).
Adverse effects for fibric acid derivatives include: _________, N/V, skin rash, gallstones, and myopathy.
T or F: When on statin therapy, the appropriate action to take if there are muscle Sxs + CK elevation > 10x ULN is to: D/C statin - follow CK weekly.
Fluvastatin 20mg lowers LDL by ___%
The max dose per day of Niaspan is: ___g/day.
Omega-3 Fatty Acids' place in therapy is for: ____________.
Ezetimibe dosing is ___mg PO daily - with or without food.
Omega-3 Fatty acids should be used as an adjunct to diet in patients with a very high TG (> or = ______mg/dL)
Which statin is most lipophilic and therefore most likely to cause myopathies?
Brand Name Rosuvastatin
T or F: Ezetimibe should be used in caution in renal or hepatic impairment and are not recommended in moderate or severe hepatic impairment.
Brand Name Pravastatin
BAS place in therapy is as an add-on therapy to statin (2nd or 3rd line agent) and ________.
LFT monitoring for niacin therapy should be done: at initiation of therapy, every __-12 weeks for the 1st year, then periodically (1-2x per year).
Niacor dosing: Initiate 50-___mg BID-TID; titrate slowly over 2-3 weeks to achieve goal dose.
Rosuvastatin 5mg lowers LDL by ___%
T or F: Statins are the most effective LDL lowering drugs and are therefore considered first line agents for LDL lowering.
Brand Name Extended Release Niacin
Fibric acid derivatives may _______ ezetimibe's bioavailability.
Which statin is the least potent in terms of % Reduction in LDL?
T or F: Niacin's place in therapy is for combined hyperlipidemias and as either an additional therapy to statin or as alternative to statin.
Brand Name Lovastatin
T or F: It is advised when using niacin, to avoid switching formulations.
T or F: Statin monitoring parameters include: muscle soreness, tenderness, or pain; CK; and ALT, AST.
Term for 'muscle symptoms with marked creatinine kinase elevation (> 10x ULN) and creatinine elevation (damage to kidneys).'
Atorvastatin 10mg lowers LDL by ___%
Niaspan dosing: Initiate ____mg HS x 1 month, then increase by _____mg/month until at desired dose
Fenofibrate has shown reduced risk of ___ events in diabetic and nondiabetic populations.
T or F: Bile Acid Sequestrant's mechanism of action with statins is intestinal drug binding resulting in INCREASED statin bioavailability.
T or F: Slo-Niacin is available as an OTC dietary supplement.
HintAnswer
An important point of patient education for Niacin is to instruct the patient to take it with _______.
Patient education for statin's includes take at _______ and report any muscle pain/weakness, or brown urine.
Contraindications for Niacin therapy include: chronic liver disease, severe gout, PUD, and _______.
Term for 'muscle symptoms with increased creatinine kinase (CK) levels.'
Which of the following are risk factors for myopathy? (a) female sex (b) older age (c) renal insufficiency (d) all of the above
T or F: Fenofibrate can be given without regard to meals
Which statin undergoes glucuronidation/minimal CYP2C9?
Adverse effects of BAS include: GI distress, constipation, decreased absorption of other drugs and a 5-10% increase in _______.
Which drug class is pregnancy category X?
Simvastatin 5mg lowers LDL by ___%
BAS are contraindicated in dysbeta-lipoproteinemia and TG > ____ mg/dL.
T or F: Patient education for Omega-3 fatty acids includes taking it immediately prior to meals to decrease fishy taste.
T or F: Pharmacodynamic interactions with other myotoxic agents (i.e. fibrates or niacin) can result in additive effects.
Fibric Acid Derivative's mechanism of interaction with statins includes: additive effects and _________ inhibition (gemfibrozil).
Fibric acid derivatives' MOA is increasing the functional activity of _______ ________.
What statin is the most potent in terms of % reduction of LDL?
Statin monitoring: Muscle soreness, tenderness, or pain's follow-up schedule includes - baseline, __-12 weeks after initiation of therapy, and each follow-up visit.
Brand Name for Omega-3 Fatty Acid
Lowest dose of Pitavastatin: ___mg
The max dose of Fenofibrate is _____mg/day.
T or F: Gemfibrozil has greater inhibition of glucuronidation than fenofibrate.
T or F: Bile Acid Sequestrants (BAS) MOA includes binding bile acid and preventing bile acid reabsorption.
Adverse effects of Omega-3 Fatty acids include: dyspepsia, nausea, fishy taste or 'fishy burp', ____ in INR in patients on warfarin with high doses (4g)
T or F: Statins increase clearance of LDL from blood.
Niacin accomplishes which of the following: (a) reduces hepatic synthesis of TG and secretion or VLDL (b) inhibits the conversion of VLDL into LDL - increased HDL (c) inhibit mobil
Brand Name Fluvastatin
T or F: Gemfibrozil should be given 30 minutes prior to meals.
Ezetimibes place in therapy is for additive ____ lowering in addition to statin.
Verapamil, Cyclosporine, Protease Inhibitors, and Diltiazem's mechanism of interaction with statins is CYP____ inhibition.
Lowest dose of Atorvastatin: __mg
T or F: Regarding statins, the risk of myotoxicity is dose related.
Brand Name long-acting (sustained-release) Niacin
Lowest dose of Simvastatin: ___mg
T or F: Regarding statin monitoring, CK's follow-up schedule includes - a baseline and as muscle symptoms develop.
Brand Name Simvastatin
Gemfibrozil normal dosing is ____mg BID
Pravastatin 10mg lowers LDL by ___%
Lowest dose of Rosuvastatin: ___mg
Atorvastatin Brand Name
T or F: CYP450 drug interactions are NOT a risk factor for myopathy because they result in increased statin concentration
T or F: Bile acid sequestrants do NOT interfere with ezetimibe's absorption.
Term for 'muscle aches or weakness without CK (creatinine kinase) elevation.'

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