Thera2-DyslipidemiaDrugs

Can you name the Thera2-DyslipidemiaDrugs?

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HintAnswer
Term for 'muscle aches or weakness without CK (creatinine kinase) elevation.'
T or F: Bile Acid Sequestrant's mechanism of action with statins is intestinal drug binding resulting in INCREASED statin bioavailability.
Lowest dose of Atorvastatin: __mg
Niacin requires ___ monitoring.
Atorvastatin Brand Name
T or F: Patient education for BAS includes: mixing powders with water, juice, or noncarbonated beverages; take with meals; do not hold in mouth or sip for prolonged periods; refrig
T or F: Statins increase clearance of LDL from blood.
T or F: An disadvantage of BAS is that they are systemically absorbed.
T or F: When on statin therapy, the appropriate action to take if there's a modest baseline elevation (< 3x ULN) of LFTs is: perform close follow-ups, but note there is no contrain
Pravastatin 10mg lowers LDL by ___%
Fibric acid derivatives may _______ ezetimibe's bioavailability.
T or F: Gemfibrozil has greater inhibition of glucuronidation than fenofibrate.
BAS are contraindicated in dysbeta-lipoproteinemia and TG > ____ mg/dL.
Brand Name Gemfibrozil
Niacin extended release has increased chance of the patient experiencing _______.
T or F: Omega-3 fatty acids work because they are alternative substrates for TG synthesis and inhibit esterification of TG and other fatty acids.
Atorvastatin 10mg lowers LDL by ___%
Pitavastatin 1mg lowers LDL by ___%
For BAS, it's wise to advise the patient to take other medications __ hour prior or 4 hours after administration.
Adverse effects for fibric acid derivatives include: _________, N/V, skin rash, gallstones, and myopathy.
T or F: XR Niacin has more hepatotoxicity and SR Niacin.
T or F: Contraindications to statin use include active or chronic liver disease, concomitant use of interacting drugs, and pregnancy.
Which of the following is NOT considered a 'pleiotropic effect' of statins: (a) improve endothelial functions, (b) plaque stabilization, (c) increase synthesis of HDL, or (d) decre
T or F: Other adverse effects of statins include: elevated hepatic transaminases, GI disturbance, headache, and rash.
Brand Name long-acting (sustained-release) Niacin
Which statin is most lipophilic and therefore most likely to cause myopathies?
T or F: When on statin therapy, the appropriate action to take if there are muscle Sxs + CK elevation > 10x ULN is to: D/C statin - follow CK weekly.
Rosuvastatin 5mg lowers LDL by ___%
What statin is the most potent in terms of % reduction of LDL?
Ezetimibe dosing is ___mg PO daily - with or without food.
Slo-Niacin's dosing: Initiate ____-500mg/day, titrate slowly.
Which of the following statins should the patient be instructed to take at bedtime: (a) atorvastatin (b) pravastatin (c) rosuvastatin (d) simvastatin (e) pitavastatin.
Statin monitoring: ALT and AST follow-up includes - a baseline, __ weeks after initiation of therapy, then annually (more frequently if indicated).
Lowest dose of Pravastatin: ___mg
Amiodarone's mechanism of interaction with statins is CYP2C9 and CYP____ inhibition.
Niacin accomplishes which of the following: (a) reduces hepatic synthesis of TG and secretion or VLDL (b) inhibits the conversion of VLDL into LDL - increased HDL (c) inhibit mobil
Fibric acid derivates' place in therapy is first line for increased ____ and as additional therapy to statins.
BAS place in therapy is as an add-on therapy to statin (2nd or 3rd line agent) and ________.
T or F: Niacin's MOA is not completely understood, but it could be used as a primary agent since it does everything 'really well.'
Which statin is the least potent in terms of % Reduction in LDL?
T or F: Regarding statin monitoring, CK's follow-up schedule includes - a baseline and as muscle symptoms develop.
T or F: Niacin's place in therapy is for combined hyperlipidemias and as either an additional therapy to statin or as alternative to statin.
Which of the following statins is NOT metabolized by CYP3A4: (a) Simvastatin (b) Pravastatin (c) Lovastatin (d) Atorvastatin?
Niacor dosing: Initiate 50-___mg BID-TID; titrate slowly over 2-3 weeks to achieve goal dose.
HintAnswer
T or F: Equivalent doses of one niacin product may be substituted for another.
The max dose of Fenofibrate is _____mg/day.
T or F: It is advised when using niacin, to avoid switching formulations.
Brand Name Cholestyramine
T or F: When on statin therapy, the appropriate action if there's myopathy Sxs with no CK elevation is to: rule out other causes and monitor, may continue statin.
The starting doses for Fenofibrate are ___mg-145mg/day.
T or F: Gemfibrozil should be given 30 minutes prior to meals.
The max dose per day of Slo-Niacin is: ___g/day.
Omega-3 Fatty Acids' place in therapy is for: ____________.
Omega-3 Fatty acids should be used as an adjunct to diet in patients with a very high TG (> or = ______mg/dL)
Brand Name Pitavastatin
Brand Name Colestipol
Lowest dose of Fluvastatin: ___mg
Brand Name for Omega-3 Fatty Acid
T or F: When on statin therapy, the appropriate action to take if LFT elevates > 3x ULN is to: retest (could be random), if persists, decrease statin dose and monitor (may continue
T or F: Statins decrease LDL receptor activity.
Lowest dose of Rosuvastatin: ___mg
Niacor's usual dose is 1.5g - ___g/day.
Contraindications for Niacin therapy include: chronic liver disease, severe gout, PUD, and _______.
Term for 'muscle symptoms with marked creatinine kinase elevation (> 10x ULN) and creatinine elevation (damage to kidneys).'
Cyclosporine may _______ plasma concentrations of ezetimibe.
Brand Name Pravastatin
Gemfibrozil normal dosing is ____mg BID
Brand Name Colesevelam
Lowest dose of Pitavastatin: ___mg
T or F: the MOA of ezetimibe inhibits absorption of dietary and biliary cholesterol by blocking transport at the brush boarder of the small intestine.
Brand Name Fenofibrate
T or F: Niacin SR is only available with a prescription.
An example of a cholesterol absorption inhibitor is: ________.
T or F: Pharmacodynamic interactions with other myotoxic agents (i.e. fibrates or niacin) can result in additive effects.
Regarding 'statins' MOA, these drugs inhibit _____________, the enzyme that catalyzes the rate limiting step in cholesterol synthesis.
T or F: Bile acid sequestrants do NOT interfere with ezetimibe's absorption.
Which drug class is pregnancy category X?
An important point of patient education for Niacin is to instruct the patient to take it with _______.
T or F: When on statin therapy, the appropriate action to take if there's muscle Sxs + moderate CK elevation (3-10 x ULN) is to: continue statin - follow CK weekly until Sxs resolv
Brand Name Simvastatin
Brand Name Immediate Release Niacin
Fibric acid contraindications include: severe ______ or hepatic disease.
T or F: Ezetimibe should be used in caution in renal or hepatic impairment and are not recommended in moderate or severe hepatic impairment.
Azole Antifungal's mechanism of interaction with statins is CYP3A4 inhibition, P-glycoprotein inhibition, and CYP____ (fluconazole).
T or F: Bile Acid Sequestrants (BAS) MOA includes binding bile acid and preventing bile acid reabsorption.
Adverse effects of BAS include: GI distress, constipation, decreased absorption of other drugs and a 5-10% increase in _______.
Statin monitoring: Muscle soreness, tenderness, or pain's follow-up schedule includes - baseline, __-12 weeks after initiation of therapy, and each follow-up visit.
Which of the following is NOT an adverse effect of ezetimibe: (a) nausea (b) diarrhea (c) flatulence (d) myalgia
HintAnswer
The max dose per day of Niaspan is: ___g/day.
T or F: Slo-Niacin is available as an OTC dietary supplement.
Brand Name Ezetimibe
Brand Name Extended Release Niacin
Fenofibrate has shown reduced risk of ___ events in diabetic and nondiabetic populations.
T or F: Statins are the most effective LDL lowering drugs and are therefore considered first line agents for LDL lowering.
Which of the following are risk factors for myopathy? (a) female sex (b) older age (c) renal insufficiency (d) all of the above
Brand Name Lovastatin
Niaspan dosing: Initiate ____mg HS x 1 month, then increase by _____mg/month until at desired dose
LFT monitoring for niacin therapy should be done: at initiation of therapy, every __-12 weeks for the 1st year, then periodically (1-2x per year).
T or F: Niacor's required multiple daily dosing may worsen compliance.
Ezetimibes place in therapy is for additive ____ lowering in addition to statin.
T or F: Patient education for Omega-3 fatty acids includes taking it immediately prior to meals to decrease fishy taste.
Niacin immediate release has increased chance of the patient experiencing _______.
Simvastatin 5mg lowers LDL by ___%
Clarithromycin and Erythromycin's mechanism of interaction with statins is: CYP_____ inhibition.
Tips to reduce flushing caused by niacin include: take with meal, take ____ 30 minutes prior to use, and avoid hot drinks, alcohol, or hot showers near dose.
T or F: CYP450 drug interactions are NOT a risk factor for myopathy because they result in increased statin concentration
Lovastatin 10mg lowers LDL by ___%
Brand Name Fluvastatin
Which statin undergoes glucuronidation/minimal CYP2C9?
T or F: Regarding statins, the risk of myotoxicity is dose related.
Omega-3 Fatty acid starting dose is: ___ g daily, which may then be increased to 4 grams daily with meals.
Fluvastatin 20mg lowers LDL by ___%
Lowest dose of Lovastatin: ___mg
Fibric Acid Derivative's mechanism of interaction with statins includes: additive effects and _________ inhibition (gemfibrozil).
Fibric acid derivatives' MOA is increasing the functional activity of _______ ________.
Grapefruit Juice's mechanism of interaction with statins is CYP_____ inhibition
Ezetimibe may ________ the anticoagulant effect of warfarin.
Term for 'muscle symptoms with increased creatinine kinase (CK) levels.'
Verapamil, Cyclosporine, Protease Inhibitors, and Diltiazem's mechanism of interaction with statins is CYP____ inhibition.
Patient education for statin's includes take at _______ and report any muscle pain/weakness, or brown urine.
Which of the following is not an adverse effect of Niacin: (a) flushing (b) myopathies (c) hyperglycemia (d) hyperuricemia (e) hepatotoxicity (f) GI upset (g) PUD
Fibric acid derivatives require ____ monitoring every 3 months for the first year, then periodically.
T or F: The combination of Fibric Acid derivatives and statins decreases the risk for myopathy.
Niacin's mechanism of interaction with statins is: _______ effects
Adverse effects of Omega-3 Fatty acids include: dyspepsia, nausea, fishy taste or 'fishy burp', ____ in INR in patients on warfarin with high doses (4g)
Lowest dose of Simvastatin: ___mg
T or F: Statin monitoring parameters include: muscle soreness, tenderness, or pain; CK; and ALT, AST.
T or F: Fenofibrate can be given without regard to meals
T or F: Statin dosing can be determined using the '6% Rule.'
Brand Name Rosuvastatin

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