Miscellaneous Quiz / Thera2-DyslipidemiaDrugs

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Can you name the Thera2-DyslipidemiaDrugs?

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HintAnswer
For BAS, it's wise to advise the patient to take other medications __ hour prior or 4 hours after administration.
T or F: Equivalent doses of one niacin product may be substituted for another.
Atorvastatin 10mg lowers LDL by ___%
T or F: When on statin therapy, the appropriate action to take if LFT elevates > 3x ULN is to: retest (could be random), if persists, decrease statin dose and monitor (may continue
Omega-3 Fatty Acids' place in therapy is for: ____________.
Verapamil, Cyclosporine, Protease Inhibitors, and Diltiazem's mechanism of interaction with statins is CYP____ inhibition.
T or F: When on statin therapy, the appropriate action to take if there's muscle Sxs + moderate CK elevation (3-10 x ULN) is to: continue statin - follow CK weekly until Sxs resolv
T or F: Bile acid sequestrants do NOT interfere with ezetimibe's absorption.
An important point of patient education for Niacin is to instruct the patient to take it with _______.
Niacor dosing: Initiate 50-___mg BID-TID; titrate slowly over 2-3 weeks to achieve goal dose.
T or F: Contraindications to statin use include active or chronic liver disease, concomitant use of interacting drugs, and pregnancy.
Lowest dose of Simvastatin: ___mg
T or F: When on statin therapy, the appropriate action to take if there are muscle Sxs + CK elevation > 10x ULN is to: D/C statin - follow CK weekly.
T or F: Regarding statin monitoring, CK's follow-up schedule includes - a baseline and as muscle symptoms develop.
Brand Name for Omega-3 Fatty Acid
T or F: Patient education for Omega-3 fatty acids includes taking it immediately prior to meals to decrease fishy taste.
Slo-Niacin's dosing: Initiate ____-500mg/day, titrate slowly.
Brand Name Pravastatin
The starting doses for Fenofibrate are ___mg-145mg/day.
Brand Name Cholestyramine
What statin is the most potent in terms of % reduction of LDL?
T or F: Gemfibrozil has greater inhibition of glucuronidation than fenofibrate.
Niacin requires ___ monitoring.
Fibric Acid Derivative's mechanism of interaction with statins includes: additive effects and _________ inhibition (gemfibrozil).
Fluvastatin 20mg lowers LDL by ___%
Which drug class is pregnancy category X?
Which of the following is NOT considered a 'pleiotropic effect' of statins: (a) improve endothelial functions, (b) plaque stabilization, (c) increase synthesis of HDL, or (d) decre
T or F: Statins are the most effective LDL lowering drugs and are therefore considered first line agents for LDL lowering.
Brand Name Fluvastatin
Statin monitoring: Muscle soreness, tenderness, or pain's follow-up schedule includes - baseline, __-12 weeks after initiation of therapy, and each follow-up visit.
T or F: The combination of Fibric Acid derivatives and statins decreases the risk for myopathy.
T or F: Statin dosing can be determined using the '6% Rule.'
Lowest dose of Lovastatin: ___mg
Brand Name Ezetimibe
Patient education for statin's includes take at _______ and report any muscle pain/weakness, or brown urine.
T or F: Niacin SR is only available with a prescription.
Ezetimibes place in therapy is for additive ____ lowering in addition to statin.
T or F: Statins decrease LDL receptor activity.
Fenofibrate has shown reduced risk of ___ events in diabetic and nondiabetic populations.
T or F: Bile Acid Sequestrants (BAS) MOA includes binding bile acid and preventing bile acid reabsorption.
Regarding 'statins' MOA, these drugs inhibit _____________, the enzyme that catalyzes the rate limiting step in cholesterol synthesis.
An example of a cholesterol absorption inhibitor is: ________.
T or F: Statins increase clearance of LDL from blood.
Fibric acid derivates' place in therapy is first line for increased ____ and as additional therapy to statins.
HintAnswer
Brand Name Immediate Release Niacin
Rosuvastatin 5mg lowers LDL by ___%
Brand Name Gemfibrozil
T or F: Niacin's place in therapy is for combined hyperlipidemias and as either an additional therapy to statin or as alternative to statin.
Fibric acid derivatives require ____ monitoring every 3 months for the first year, then periodically.
Amiodarone's mechanism of interaction with statins is CYP2C9 and CYP____ inhibition.
Pravastatin 10mg lowers LDL by ___%
T or F: Niacor's required multiple daily dosing may worsen compliance.
T or F: Statin monitoring parameters include: muscle soreness, tenderness, or pain; CK; and ALT, AST.
T or F: CYP450 drug interactions are NOT a risk factor for myopathy because they result in increased statin concentration
Ezetimibe may ________ the anticoagulant effect of warfarin.
T or F: Bile Acid Sequestrant's mechanism of action with statins is intestinal drug binding resulting in INCREASED statin bioavailability.
Lowest dose of Rosuvastatin: ___mg
Omega-3 Fatty acid starting dose is: ___ g daily, which may then be increased to 4 grams daily with meals.
Brand Name Extended Release Niacin
Statin monitoring: ALT and AST follow-up includes - a baseline, __ weeks after initiation of therapy, then annually (more frequently if indicated).
T or F: An disadvantage of BAS is that they are systemically absorbed.
Brand Name long-acting (sustained-release) Niacin
Clarithromycin and Erythromycin's mechanism of interaction with statins is: CYP_____ inhibition.
Cyclosporine may _______ plasma concentrations of ezetimibe.
T or F: the MOA of ezetimibe inhibits absorption of dietary and biliary cholesterol by blocking transport at the brush boarder of the small intestine.
BAS place in therapy is as an add-on therapy to statin (2nd or 3rd line agent) and ________.
Term for 'muscle symptoms with marked creatinine kinase elevation (> 10x ULN) and creatinine elevation (damage to kidneys).'
T or F: Other adverse effects of statins include: elevated hepatic transaminases, GI disturbance, headache, and rash.
Tips to reduce flushing caused by niacin include: take with meal, take ____ 30 minutes prior to use, and avoid hot drinks, alcohol, or hot showers near dose.
T or F: When on statin therapy, the appropriate action if there's myopathy Sxs with no CK elevation is to: rule out other causes and monitor, may continue statin.
T or F: XR Niacin has more hepatotoxicity and SR Niacin.
Brand Name Rosuvastatin
T or F: Ezetimibe should be used in caution in renal or hepatic impairment and are not recommended in moderate or severe hepatic impairment.
T or F: Slo-Niacin is available as an OTC dietary supplement.
Brand Name Colestipol
Atorvastatin Brand Name
Ezetimibe dosing is ___mg PO daily - with or without food.
Which of the following is not an adverse effect of Niacin: (a) flushing (b) myopathies (c) hyperglycemia (d) hyperuricemia (e) hepatotoxicity (f) GI upset (g) PUD
Lowest dose of Fluvastatin: ___mg
Adverse effects of BAS include: GI distress, constipation, decreased absorption of other drugs and a 5-10% increase in _______.
Lowest dose of Pitavastatin: ___mg
Which of the following statins is NOT metabolized by CYP3A4: (a) Simvastatin (b) Pravastatin (c) Lovastatin (d) Atorvastatin?
Which statin is most lipophilic and therefore most likely to cause myopathies?
Which statin undergoes glucuronidation/minimal CYP2C9?
Niacin immediate release has increased chance of the patient experiencing _______.
Pitavastatin 1mg lowers LDL by ___%
Which of the following statins should the patient be instructed to take at bedtime: (a) atorvastatin (b) pravastatin (c) rosuvastatin (d) simvastatin (e) pitavastatin.
T or F: Omega-3 fatty acids work because they are alternative substrates for TG synthesis and inhibit esterification of TG and other fatty acids.
HintAnswer
Niacin extended release has increased chance of the patient experiencing _______.
Fibric acid derivatives may _______ ezetimibe's bioavailability.
Term for 'muscle symptoms with increased creatinine kinase (CK) levels.'
T or F: Pharmacodynamic interactions with other myotoxic agents (i.e. fibrates or niacin) can result in additive effects.
Term for 'muscle aches or weakness without CK (creatinine kinase) elevation.'
The max dose of Fenofibrate is _____mg/day.
Fibric acid contraindications include: severe ______ or hepatic disease.
The max dose per day of Niaspan is: ___g/day.
Brand Name Fenofibrate
Lowest dose of Atorvastatin: __mg
T or F: Gemfibrozil should be given 30 minutes prior to meals.
Brand Name Pitavastatin
Grapefruit Juice's mechanism of interaction with statins is CYP_____ inhibition
Omega-3 Fatty acids should be used as an adjunct to diet in patients with a very high TG (> or = ______mg/dL)
Which statin is the least potent in terms of % Reduction in LDL?
BAS are contraindicated in dysbeta-lipoproteinemia and TG > ____ mg/dL.
Which of the following are risk factors for myopathy? (a) female sex (b) older age (c) renal insufficiency (d) all of the above
Brand Name Lovastatin
Fibric acid derivatives' MOA is increasing the functional activity of _______ ________.
The max dose per day of Slo-Niacin is: ___g/day.
T or F: Patient education for BAS includes: mixing powders with water, juice, or noncarbonated beverages; take with meals; do not hold in mouth or sip for prolonged periods; refrig
Lovastatin 10mg lowers LDL by ___%
LFT monitoring for niacin therapy should be done: at initiation of therapy, every __-12 weeks for the 1st year, then periodically (1-2x per year).
Brand Name Simvastatin
T or F: It is advised when using niacin, to avoid switching formulations.
Brand Name Colesevelam
T or F: Regarding statins, the risk of myotoxicity is dose related.
Niacin's mechanism of interaction with statins is: _______ effects
Azole Antifungal's mechanism of interaction with statins is CYP3A4 inhibition, P-glycoprotein inhibition, and CYP____ (fluconazole).
Adverse effects for fibric acid derivatives include: _________, N/V, skin rash, gallstones, and myopathy.
Simvastatin 5mg lowers LDL by ___%
Niaspan dosing: Initiate ____mg HS x 1 month, then increase by _____mg/month until at desired dose
T or F: Niacin's MOA is not completely understood, but it could be used as a primary agent since it does everything 'really well.'
Niacin accomplishes which of the following: (a) reduces hepatic synthesis of TG and secretion or VLDL (b) inhibits the conversion of VLDL into LDL - increased HDL (c) inhibit mobil
Lowest dose of Pravastatin: ___mg
T or F: When on statin therapy, the appropriate action to take if there's a modest baseline elevation (< 3x ULN) of LFTs is: perform close follow-ups, but note there is no contrain
Niacor's usual dose is 1.5g - ___g/day.
Adverse effects of Omega-3 Fatty acids include: dyspepsia, nausea, fishy taste or 'fishy burp', ____ in INR in patients on warfarin with high doses (4g)
T or F: Fenofibrate can be given without regard to meals
Gemfibrozil normal dosing is ____mg BID
Which of the following is NOT an adverse effect of ezetimibe: (a) nausea (b) diarrhea (c) flatulence (d) myalgia
Contraindications for Niacin therapy include: chronic liver disease, severe gout, PUD, and _______.

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