Miscellaneous Quiz / Thera2-DyslipidemiaDrugs

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Can you name the Thera2-DyslipidemiaDrugs?

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Which statin is the least potent in terms of % Reduction in LDL?
Brand Name Ezetimibe
T or F: Ezetimibe should be used in caution in renal or hepatic impairment and are not recommended in moderate or severe hepatic impairment.
Lowest dose of Simvastatin: ___mg
Fibric Acid Derivative's mechanism of interaction with statins includes: additive effects and _________ inhibition (gemfibrozil).
Brand Name Cholestyramine
LFT monitoring for niacin therapy should be done: at initiation of therapy, every __-12 weeks for the 1st year, then periodically (1-2x per year).
T or F: the MOA of ezetimibe inhibits absorption of dietary and biliary cholesterol by blocking transport at the brush boarder of the small intestine.
Brand Name Fenofibrate
Which of the following is NOT an adverse effect of ezetimibe: (a) nausea (b) diarrhea (c) flatulence (d) myalgia
Fibric acid derivatives' MOA is increasing the functional activity of _______ ________.
Pravastatin 10mg lowers LDL by ___%
T or F: When on statin therapy, the appropriate action to take if LFT elevates > 3x ULN is to: retest (could be random), if persists, decrease statin dose and monitor (may continue
Niacor's usual dose is 1.5g - ___g/day.
Contraindications for Niacin therapy include: chronic liver disease, severe gout, PUD, and _______.
Brand Name Simvastatin
BAS place in therapy is as an add-on therapy to statin (2nd or 3rd line agent) and ________.
T or F: When on statin therapy, the appropriate action to take if there are muscle Sxs + CK elevation > 10x ULN is to: D/C statin - follow CK weekly.
T or F: Statins decrease LDL receptor activity.
Which of the following statins is NOT metabolized by CYP3A4: (a) Simvastatin (b) Pravastatin (c) Lovastatin (d) Atorvastatin?
T or F: When on statin therapy, the appropriate action if there's myopathy Sxs with no CK elevation is to: rule out other causes and monitor, may continue statin.
Simvastatin 5mg lowers LDL by ___%
T or F: Pharmacodynamic interactions with other myotoxic agents (i.e. fibrates or niacin) can result in additive effects.
T or F: Bile acid sequestrants do NOT interfere with ezetimibe's absorption.
Atorvastatin 10mg lowers LDL by ___%
Statin monitoring: Muscle soreness, tenderness, or pain's follow-up schedule includes - baseline, __-12 weeks after initiation of therapy, and each follow-up visit.
Patient education for statin's includes take at _______ and report any muscle pain/weakness, or brown urine.
Regarding 'statins' MOA, these drugs inhibit _____________, the enzyme that catalyzes the rate limiting step in cholesterol synthesis.
T or F: Statins are the most effective LDL lowering drugs and are therefore considered first line agents for LDL lowering.
T or F: Niacin's place in therapy is for combined hyperlipidemias and as either an additional therapy to statin or as alternative to statin.
Brand Name Immediate Release Niacin
Niacor dosing: Initiate 50-___mg BID-TID; titrate slowly over 2-3 weeks to achieve goal dose.
T or F: When on statin therapy, the appropriate action to take if there's a modest baseline elevation (< 3x ULN) of LFTs is: perform close follow-ups, but note there is no contrain
Gemfibrozil normal dosing is ____mg BID
Fenofibrate has shown reduced risk of ___ events in diabetic and nondiabetic populations.
Brand Name Colestipol
Lowest dose of Lovastatin: ___mg
The max dose per day of Niaspan is: ___g/day.
T or F: Other adverse effects of statins include: elevated hepatic transaminases, GI disturbance, headache, and rash.
Brand Name Extended Release Niacin
Fibric acid derivates' place in therapy is first line for increased ____ and as additional therapy to statins.
Which of the following statins should the patient be instructed to take at bedtime: (a) atorvastatin (b) pravastatin (c) rosuvastatin (d) simvastatin (e) pitavastatin.
T or F: Statin monitoring parameters include: muscle soreness, tenderness, or pain; CK; and ALT, AST.
Amiodarone's mechanism of interaction with statins is CYP2C9 and CYP____ inhibition.
The starting doses for Fenofibrate are ___mg-145mg/day.
T or F: CYP450 drug interactions are NOT a risk factor for myopathy because they result in increased statin concentration
Grapefruit Juice's mechanism of interaction with statins is CYP_____ inhibition
Lowest dose of Pitavastatin: ___mg
Statin monitoring: ALT and AST follow-up includes - a baseline, __ weeks after initiation of therapy, then annually (more frequently if indicated).
Rosuvastatin 5mg lowers LDL by ___%
Ezetimibe dosing is ___mg PO daily - with or without food.
Which of the following is not an adverse effect of Niacin: (a) flushing (b) myopathies (c) hyperglycemia (d) hyperuricemia (e) hepatotoxicity (f) GI upset (g) PUD
Fluvastatin 20mg lowers LDL by ___%
What statin is the most potent in terms of % reduction of LDL?
Which statin is most lipophilic and therefore most likely to cause myopathies?
T or F: Patient education for BAS includes: mixing powders with water, juice, or noncarbonated beverages; take with meals; do not hold in mouth or sip for prolonged periods; refrig
BAS are contraindicated in dysbeta-lipoproteinemia and TG > ____ mg/dL.
Brand Name Fluvastatin
T or F: Gemfibrozil has greater inhibition of glucuronidation than fenofibrate.
An example of a cholesterol absorption inhibitor is: ________.
Adverse effects for fibric acid derivatives include: _________, N/V, skin rash, gallstones, and myopathy.
T or F: Equivalent doses of one niacin product may be substituted for another.
Lowest dose of Rosuvastatin: ___mg
T or F: Bile Acid Sequestrants (BAS) MOA includes binding bile acid and preventing bile acid reabsorption.
Pitavastatin 1mg lowers LDL by ___%
Term for 'muscle symptoms with marked creatinine kinase elevation (> 10x ULN) and creatinine elevation (damage to kidneys).'
An important point of patient education for Niacin is to instruct the patient to take it with _______.
The max dose per day of Slo-Niacin is: ___g/day.
Niacin's mechanism of interaction with statins is: _______ effects
Brand Name Colesevelam
Brand Name long-acting (sustained-release) Niacin
Fibric acid contraindications include: severe ______ or hepatic disease.
Tips to reduce flushing caused by niacin include: take with meal, take ____ 30 minutes prior to use, and avoid hot drinks, alcohol, or hot showers near dose.
Lowest dose of Atorvastatin: __mg
Adverse effects of Omega-3 Fatty acids include: dyspepsia, nausea, fishy taste or 'fishy burp', ____ in INR in patients on warfarin with high doses (4g)
Ezetimibes place in therapy is for additive ____ lowering in addition to statin.
T or F: Fenofibrate can be given without regard to meals
T or F: XR Niacin has more hepatotoxicity and SR Niacin.
Lovastatin 10mg lowers LDL by ___%
Ezetimibe may ________ the anticoagulant effect of warfarin.
T or F: An disadvantage of BAS is that they are systemically absorbed.
T or F: Statin dosing can be determined using the '6% Rule.'
Azole Antifungal's mechanism of interaction with statins is CYP3A4 inhibition, P-glycoprotein inhibition, and CYP____ (fluconazole).
T or F: Regarding statins, the risk of myotoxicity is dose related.
Term for 'muscle aches or weakness without CK (creatinine kinase) elevation.'
Brand Name Pitavastatin
Niacin extended release has increased chance of the patient experiencing _______.
Brand Name Rosuvastatin
Which drug class is pregnancy category X?
T or F: Bile Acid Sequestrant's mechanism of action with statins is intestinal drug binding resulting in INCREASED statin bioavailability.
For BAS, it's wise to advise the patient to take other medications __ hour prior or 4 hours after administration.
T or F: The combination of Fibric Acid derivatives and statins decreases the risk for myopathy.
Cyclosporine may _______ plasma concentrations of ezetimibe.
T or F: Niacin SR is only available with a prescription.
Term for 'muscle symptoms with increased creatinine kinase (CK) levels.'
T or F: Contraindications to statin use include active or chronic liver disease, concomitant use of interacting drugs, and pregnancy.
Niaspan dosing: Initiate ____mg HS x 1 month, then increase by _____mg/month until at desired dose
Slo-Niacin's dosing: Initiate ____-500mg/day, titrate slowly.
T or F: Slo-Niacin is available as an OTC dietary supplement.
T or F: Omega-3 fatty acids work because they are alternative substrates for TG synthesis and inhibit esterification of TG and other fatty acids.
T or F: Patient education for Omega-3 fatty acids includes taking it immediately prior to meals to decrease fishy taste.
Atorvastatin Brand Name
Niacin requires ___ monitoring.
Omega-3 Fatty acids should be used as an adjunct to diet in patients with a very high TG (> or = ______mg/dL)
Which of the following are risk factors for myopathy? (a) female sex (b) older age (c) renal insufficiency (d) all of the above
T or F: Statins increase clearance of LDL from blood.
The max dose of Fenofibrate is _____mg/day.
Brand Name Lovastatin
Clarithromycin and Erythromycin's mechanism of interaction with statins is: CYP_____ inhibition.
T or F: Niacin's MOA is not completely understood, but it could be used as a primary agent since it does everything 'really well.'
Fibric acid derivatives may _______ ezetimibe's bioavailability.
Verapamil, Cyclosporine, Protease Inhibitors, and Diltiazem's mechanism of interaction with statins is CYP____ inhibition.
Omega-3 Fatty acid starting dose is: ___ g daily, which may then be increased to 4 grams daily with meals.
T or F: Regarding statin monitoring, CK's follow-up schedule includes - a baseline and as muscle symptoms develop.
Niacin accomplishes which of the following: (a) reduces hepatic synthesis of TG and secretion or VLDL (b) inhibits the conversion of VLDL into LDL - increased HDL (c) inhibit mobil
Which of the following is NOT considered a 'pleiotropic effect' of statins: (a) improve endothelial functions, (b) plaque stabilization, (c) increase synthesis of HDL, or (d) decre
T or F: It is advised when using niacin, to avoid switching formulations.
T or F: When on statin therapy, the appropriate action to take if there's muscle Sxs + moderate CK elevation (3-10 x ULN) is to: continue statin - follow CK weekly until Sxs resolv
Lowest dose of Pravastatin: ___mg
Niacin immediate release has increased chance of the patient experiencing _______.
Which statin undergoes glucuronidation/minimal CYP2C9?
Brand Name for Omega-3 Fatty Acid
T or F: Gemfibrozil should be given 30 minutes prior to meals.
Lowest dose of Fluvastatin: ___mg
Brand Name Pravastatin
Adverse effects of BAS include: GI distress, constipation, decreased absorption of other drugs and a 5-10% increase in _______.
Brand Name Gemfibrozil
Fibric acid derivatives require ____ monitoring every 3 months for the first year, then periodically.
T or F: Niacor's required multiple daily dosing may worsen compliance.
Omega-3 Fatty Acids' place in therapy is for: ____________.

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