| Endpoints | Interstate | Cities on Route |
| Cove Fort, UT to Baltimore, MD | |
| Las Cruces, NM to Buffalo, WY | |
| Barstow, CA to Wilmington, NC | |
| Chesapeake, VA to St. Louis, MO | |
| New Orleans, LA to Chicago, IL | |
| San Francisco, CA to Teaneck, NJ | |
| Kansas City, MO to Pembina, ND | |
| Duluth, MN to Laredo, TX | |
| Billings, MT to Detroit, MI | |
| Seattle, WA to Boston, MA | |
| | Endpoints | Interstate | Cities on Route |
| San Ysidro, CA to Blaine, WA | |
| Miami, FL to Houlton, ME | |
| Mobile, AL to Gary, IN | |
| Louisville, KY to Cleveland, OH | |
| Santa Monica, CA to Jacksonville, FL | |
| San Diego, CA to Sweetgrass, MT | |
| Kent, TX to Florence, SC | |
| Miami, FL to Sault Ste. Marie, MI | |
| Dandridge, TN to Fisher's Landing, NY | |
| Montgomery, AL to Petersburg, VA | |
|