| Children/Stepchildren | President |
John (aka Jack), James (aka Chip), Donnell (aka Jeff), Amy | |
| John* | |
Unnamed Baby Girl** (though some sources say she was posthumously called Arabella), Caroline, John (aka John-John), Patrick** | |
| Andrew***, Lincoya (ophaned Indian brought home); Guardian for Caroline, Eliza, Edward & Anthony Butler; John, Andrew & Daniel Donelson; Andrew Hutchings; & sporadically for others | |
| Malia, Natasha (aka Sasha) | |
| Katherine (aka Katie)**, Ida** | |
| Anne, Sarah (aka Knox,Knoxie), Octavia**, Margaret**, Mary Elizabeth (aka Betty), Richard | |
| Millard, Mary Abigail (aka Abby) | |
Robert, Edward (aka Eddie)**, William (aka Willie)**, Thomas (aka Tad)** | |
| William**, Chester (aka Alan), Ellen (aka Nell) | |
| Martha, Charles, Mary, Robert, Andrew | |
| Chelsea | |
| Sardis Birchard (aka Birchard), James, Rutherford, Joseph (aka Jody)**, George**, Frances (aka Fanny), Scott, Manning** | |
Eliza (aka Trot)**, Harry (aka Hal), James, Mary (aka Mollie), Irvin, Abram, Edward** | |
Russell, Mary (aka Mamie), Unnamed Baby Girl**, Elizabeth | |
Margaret (aka Nistha), Jessie, Eleanor (aka Nellie) | |
| Marshall (his wife's nephew who was their ward) | |
| Frederick, Ulysses (aka Buck), Ellen (aka Nellie), Jesse | |
| Eliza, James**, Maria | |
| Abigail (aka Nabby,Amelia), John, Susanna**, Charles, Thomas, Elizabeth** | |
Eugene Marshall* (aka Marshall, Pete), Elizabeth Ann (aka Emma; from extra-marital affair; he supported but wouldn't meet her) | |
| Patricia (aka Tricia), Julie | |
| | Children/Stepchildren | President |
Oscar (illegitimate son he accepted responsibility for but paternity was questionable; adopted by another couple), Ruth**, Esther, Marion, Richard (aka Dick, Rich), Francis | |
| John, Calvin** | |
| Abraham, John, Martin, Unnamed Baby Boy**, Smith, Unnamed Baby Girl** | |
| Barbara, Jenna | |
| Mary, Robert, John, Letitia (aka Letty), Elizabeth (aka Lizzie), Anne**, Alice, Tazewell, David (aka Gardie), John Alexander (Alex), Julia, Lachlan, Lyon, Robert Fitzwalter, Pearl | |
| Lynda (aka Lynda Bird), Luci | |
| Elizabeth (aka Betsy), John Cleves, Lucy, William, John Scott, Benjamin, Mary, Carter, Anna, James** | |
| Mary, Harriet (orphaned nieces were his wards) | |
| Anna, James (aka Jimmy), Franklin**, Elliott, Franklin, John | |
| Michael, John (aka Jack), Steven, Susan | |
John* (aka Jacky), Martha* (aka Patsy)**; ward of stepgrandchildren Eleanor (aka Nelly) & George (aka Wash) | |
| Mary Margaret (aka Margaret) | |
| Doud (aka Ikky)**, John | |
Martha (aka Patsy), Jane**, Unnamed Baby Boy**, Mary (aka Polly or Maria), Lucy**, Lucy II** | |
Alice, Theodore (aka Ted), Kermit, Ethel, Archibald (aka Archie), Quentin | |
| Herbert, Allan | |
Franklin**, Franklin, (aka Frank)**, Benjamin (aka Bennie)** | |
| George, Pauline (aka Robin)**, John (aka Jeb), Neil, Marvin, Dorothy (aka Doro) | |
| George, John, Unnamed Baby Boy**, Charles, Louisa** | |
| Robert, Helen, Charles | |
Maureen, Michael***, Christine**, Patricia (aka Patti), Ronald (aka Ron) | |
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