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Haematology - Myeloproliferative disorders
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The four myeloproliferative disorders are myelofibrosis, polycythaemia vera, chronic myeloid leukaemia and what?
A blood film has immature neutrophils with large nuclei and RBCs containing nuclei. What is the name of this picture?
A patient has a slow onset disease, with bruising, fatigue, weight loss and splenomegaly. A blood screen shows increased WBCs, increased platelets, anaemia and high uric acid. Dx?
What would a bone marrow biopsy show in chronic myeloid leukaemia?
A patient's genetics show they have a t9:22 (Philadelphia translocation). What disorder is this diagnostic of?
What is the treatment for chronic myeloid leukaemia?
What is the treatment for myelofibrosis?
A patient has a slow onset of anaemia, weight loss and night sweats, as well as a massively enlarged spleen. They also experience episodic severe pain in the left shoulder. Dx?
Which disorder will have teardrop red cells evident on blood film?
What will a bone marrow biopsy show in myelofibrosis?
An asymptomatic patient with elevated platelets has a bone marrow biopsy which shows many enlarged, mature megakaryocytes. What is the likely diagnosis?
What procedure would be done in essential thrombocythaemia patients to reduce the risk of bleeding or clotting before surgery?
A patient has a blood screen showing increased platelet count, abnormal platelet morphology, marked increase in megakaryocytes, a mild anaemia and normal white blood cell count. Dx
What is the treatment for essential thrombocythaemia
How does albumin respond to inflammation
How does fibrinogen respond to inflammation?
How does von Willebrand factor respond to inflammation?
How does transferrin respond to inflammation?
What cell is CRP synthesised by?
A blood film shows a neutrophil with darker granules, vacuoles and a paler nucleus. What is the cause of this toxic change?
What are Dohle bodies in the neutrophil produced in response to?
A patient has low serum iron, normal serum ferritin and low transferrin. What is the likely diagnosis?
What effect will dehydration have on haemoglobin levels?
What effect will obstructive sleep apnoea have on haemoglobin levels?
What effect will COPD have on haemoglobin levels?
A patient with high haemoglobin and a low EPO level has what condition?
A patient with a high haemoglobin and a high EPO level has what condition?
A patient has had a gradual onset of headache, dizziness, weakness and sweating. On examination, he has red skin, splenomegaly and hepatomegaly. What is the diagnosis?
A patient has lab results showing increased haemoglobin, increased neutrophils, increased platelets, decreased EPO. On bone marrow biopsy, there was hypercellularity. Dx?
Which genetic test is diagnostic for polycythaemia vera?
What is the treatment for polycythaemia vera?
A patient has a high serum iron, high ferritin and a high transferrin saturation. What is the diagnosis?
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