| Strikeouts/ Years | Player | Team(s) |
| 5,714/ 1966-1993 | |
| 4,875/ 1988-2009 | |
| 4,672/ 1984-2007 | |
| 4,136/ 1965-1988 | |
| 3,701/ 1970-1992 | |
| 3,640/ 1967-1986 | |
| 3,574/ 1966-1988 | |
| 3,534/ 1962-1983 | |
| 3,508/ 1907-1927 | |
| 3,371/ 1986-2008 | |
| 3,342/ 1964-1987 | |
| 3,192/ 1965-1983 | |
| 3,154/ 1992-2009 | |
| 3,117/ 1959-1975 | |
| 3,116/ 1988-2007 | |
| 3,084/ 1988-2009 | |
| 2,855/ 1955-1971 | |
| 2,832/ 1963-1978 | |
| 2,813/ 1991-2008 | |
| 2,803/ 1890-1911 | |
| 2,773/ 1973-1993 | |
| 2,668/ 1986-2003 | |
| 2,610/ 1986-2002 | |
| 2,607/ 1987-2008 | |
| 2,583/ 1942-1965 | |
| 2,581/ 1936-1956 | |
| 2,564/ 1880-1893 | |
| 2,556/ 1967-1985 | |
| 2,536/ 1998-present | |
| 2,502/ 1900-1916 | |
| 2,486/ 1956-1969 | |
| 2,478/ 1977-1994 | |
| 2,464/ 1984-1999 | |
| 2,461/ 1959-1983 | |
| 2,453/ 1961-1975 | |
| 2,416/ 1964-1982 | |
| 2,405/ 1986-2010 | |
| 2,401/ 1975-1998 | |
| 2,397/ 1986-2005 | |
| 2,396/ 1955-1966 | |
| 2,362/ 1970-1994 | |
| 2,357/ 1948-1966 | |
| 2,334/ 1939-1963 | |
| 2,316/ 1897-1910 | |
| 2,303/ 1960-1975 | |
| 2,293/ 1984-2000 | |
| 2,266/ 1925-1941 | |
| 2,251/ 1995-2010 | |
| 2,246/ 1901-1917 | |
| 2,245/ 1963-1989 | |
| 2,212/ 1965-1984 | |
| 2,201/ 1987-2007 | |
| 2,198/ 1911-1930 | |
| 2,175/ 1969-1986 | |
| 2,167/ 1954-1971 | |
| 2,156/ 1992-present | |
| 2,149/ 1976-1998 | |
| 2,082/ 1929-1953 | |
| 2,074/ 1980-1997 | |
| 2,045/ 1915-1935 | |
| 2,017/ 2001-present | |
| 2,015/ 1972-1991 | |
| 2,014/ 1983-2000 | |
| 2,012/ 1965-1979 | |
| 2,000/ 1989-2002 | |
| 1,999/ 1945-1964 | |
| 1,994/ 1989-2004 | |
| | Strikeouts/ Years | Player | Team(s) |
| 1,987/ 1924-1947 | |
| 1,978/ 1882-1894 | |
| 1,976/ 1997-present | |
| 1,974/ 1987-2005 | |
| 1,969/ 1978-1994 | |
| 1,968/ 1989-2008 | |
| 1,956/ 1950-1967 | |
| 1,955/ 1986-2001 | |
| 1,942/ 1978-1998 | |
| 1,934/ 1998-present | |
| 1,934/ 1889-1901 | |
| 1,928/ 1988-2009 | |
| 1,928/ 1996-present | |
| 1,918/ 1995-2008 | |
| 1,907/ 1969-1990 | |
| 1,877/ 2000-present | |
| 1,868/ 1890-1906 | |
| 1,850/ 1880-1892 | |
| 1,844/ 1982-1996 | |
| 1,830/ 1880-1891 | |
| 1,803/ 1881-1894 | |
| 1,799/ 1875-1892 | |
| 1,796/ 1939-1955 | |
| 1,791/ 1999-present | |
| 1,778/ 1975-1988 | |
| 1,766/ 1987-2003 | |
| 1,765/ 1998-present | |
| 1,760/ 1965-1983 | |
| 1,759/ 2001-present | |
| 1,758/ 1995-2009 | |
| 1,747/ 1967-1988 | |
| 1,743/ 1983-1997 | |
| 1,742/ 1997-present | |
| 1,741/ 1978-1995 | |
| 1,736/ 1904-1917 | |
| 1,735/ 1983-1999 | |
| 1,734/ 1951-1966 | |
| 1,728/ 1965-1979 | |
| 1,728/ 1957-1973 | |
| 1,727/ 1983-1997 | |
| 1,723/ 1977-1992 | |
| 1,715/ 1994-2010 | |
| 1,715/ 1984-2001 | |
| 1,711/ 1903-1925 | |
| 1,709/ 1955-1968 | |
| 1,704/ 1878-1887 | |
| 1,703/ 1962-1974 | |
| 1,702/ 1903-1919 | |
| 1,700/ 1882-1892 | |
| 1,699/ 1999-present | |
| 1,697/ 1947-1967 | |
| 1,689/ 1980-1994 | |
| 1,683/ 2000-present | |
| 1,679/ 1976-1994 | |
| 1,667/ 1928-1943 | |
| 1,674/ 1930-1946 | |
| 1,673/ 1975-1993 | |
| 1,669/ 1979-1998 | |
| 1,668/ 1991-2002 | |
| 1,667/ 1982-1995 | |
| 1,665/ 1887-1955 | |
| 1,664/ 1992-2006 | |
| 1,663/ 1999-present | |
| 1,659/ 1997-present | |
| 1,651/ 1898-1910 | |
| 1,647/ 1964-1982 | |
| 1,643/ 1991-2006 | |
| | Strikeouts/ Years | Player | Team(s) |
| 1,639/ 1961-1977 | |
| 1,632/ 1959-1977 | |
| 1,632/ 1999-present | |
| 1,629/ 1959-1973 | |
| 1,625/ 1968-1979 | |
| 1,621/ 2001-present | |
| 1,621/ 1897-1912 | |
| 1,621/ 1973-1985 | |
| 1,614/ 1960-1976 | |
| 1,612/ 1957-1975 | |
| 1,611/ 1978-1996 | |
| 1,610/ 1952-1972 | |
| 1,606/ 1984-2002 | |
| 1,605/ 1960-1971 | |
| 1,601/ 1965-1978 | |
| 1,594/ 1983-1995 | |
| 1,594/ 1986-1998 | |
| 1,593/ 1908-1925 | |
| 1,591/ 1993-2008 | |
| 1,590/ 1983-1995 | |
| 1,587/ 1966-1983 | |
| 1,587/ 1988-2002 | |
| 1,576/ 1959-1975 | |
| 1,576/ 1998-present | |
| 1,575/ 1952-1964 | |
| 1,571/ 1881-1890 | |
| 1,554/ 2002-present | |
| 1,553/ 1994-2008 | |
| 1,553/ 1884-1897 | |
| 1,552/ 1898-1918 | |
| 1,542/ 1986-2002 | |
| 1,542/ 2001-present | |
| 1,538/ 1984-1998 | |
| 1,534/ 1961-1971 | |
| 1,534/ 1941-1958 | |
| 1,528/ 1971-1989 | |
| 1,522/ 1957-1974 | |
| 1,519/ 1987-2000 | |
| 1,516/ 1971-1983 | |
| 1,515/ 1885-1890 | |
| 1,515/ 1964-1977 | |
| 1,512/ 1916-1934 | |
| 1,512/ 1962-1975 | |
| 1,512/ 1964-1975 | |
| 1,507/ 1931-1945 | |
| 1,506/ 1997-present | |
| 1,502/ 1972-1994 | |
| 1,493/ 1964-1977 | |
| 1,493/ 1971-1980 | |
| 1,491/ 1975-1992 | |
| 1,491/ 1971-1985 | |
| 1,486/ 1999-present | |
| 1,482/ 1902-1915 | |
| 1,482/ 1989-2001 | |
| 1,481/ 1966-1984 | |
| 1,480/ 1993-2007 | |
| 1,478/ 1976-1989 | |
| 1,475/ 1965-1979 | |
| 1,473/ 1976-1990 | |
| 1,471/ 1914-1933 | |
| 1,469/ 1979-1991 | |
| 1,468/ 1930-1943 | |
| 1,467/ 1995-2006 | |
| 1,459/ 2002-present | |
| 1,455/ 1923-1941 | |
| 1,452/ 1969-1983 | |
|