Science / Neuropharmacology Part III

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Can you name the drugs matching each description?

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DescriptionDrugNeurotransmitter involved
Name an addictive drug that most adults use that potentiates GABA A receptors and depresses NMDA receptorsGABA, Glutamate
Name a D2-like receptor, 5-HT2 receptor antagonist used to treat the + and - symptoms of schizophreniaDopamine, Serotonin
Name an anti-VEGF antibody that can treat wet age-related macular degeneration by blocking blood vessel formation behind the retina-- (VEGF)
Name a beta 1/beta 2 receptor antagonist that treats glaucoma by reducing aqueous humour production (eyedrops)Epinephrine, Norepinephrine
Name a drug that inhibits reuptake of both 5-HT and NE; treats depression, generalized anxiety, panic disorder, social phobia, PTSDSerotonin, Norepinephrine
Name a first choice non-BZ GABA A agonist drug for insomnia with an intermediate half lifeGABA
Name a short-acting muscarinic receptor antagonist used to dilate the pupils for an eye examAcetylcholine
Name a long-acting muscarinic receptor that produces long-lasting mydriasis and cycloplegia for a prolonged eye examAcetylcholine
Name an alpha 2 receptor agonist that reduces aqueous humour production (eyedrops)Norepinephrine, Epinephrine
Name a drug combination (name two drugs or the trade name of the combo) of an antidepressant and an antipsychotic used to treat bipolar disorder. Use '+' or 'and' to separateDopamine, Serotonin
Name a drug typically considered an anticonvulsant that is also indicated for treatment of bipolar disorder-- (Na+)
Name a prostaglandin analogue, an agonist of the FP receptor that increases aqueous humour outflow through the uveoscleral route (eyedrops)Prostaglandin
Name the classic drug for the treatment of bipolar disorder that inhibits the hydrolysis of inositol-1-phosphate-- (Inositol-1-monophosphate)
*NOT ON DRUG LIST - FROM LECTURE* Name a drug in eyedrops that causes constriction of the ciliary muscles to open the trabecular meshwork (serious miosis)Acetylcholine
DescriptionDrugNeurotransmitter involved
Name the benzodiazepine used for insomnia with the shortest 1/2 life - good for people who need to be alert in the morningGABA
Name a drug used to treat alcohol addiction that is a glutamate antagonist and increases GABA releaseGlutamate, GABA
Name a 5-HT transport inhibitor with alpha 2 agonist and H1 antagonist activity that treats depression and insomniaSerotonin
*NOT ON DRUG LIST - FROM LECTURE* Name a drug in eyedrops that produces mydriasis as an alpha 1 receptor agonist (causes vasoconstriction, too)Epinephrine, Norepinephrine
Name a melatonin receptor agonist used to treat insomnia; interaction only with a particular SSRIMelatonin
Name an SSRI that treats depression by increasing serotonin in the synaptic cleftSerotonin
Name an agonist of the 5-HT 1A receptor that reduces some 5-HT neuron firing. Treats generalized anxiety, anxiety with depressionSerotonin
Name a benzodiazepine, which potentiates the activity of the GABA A receptor, used to treat anxietyGABA
Name a D2-like receptor antagonist used to treat the positive symptoms of schizophrenia (not the negative ones)Dopamine
Name a carbonic anhydrase inhibitor that reduces aqueous humour production (eyedrops)-- (HC03-)
Name a novel antidepressant that has little to no effect on serotonin uptakeDopamine or Serotonin (but not reuptake)
Name a drug that causes acetaldehyde buildup (inhibits aldehyde dehydrogenase) and makes you sick as a dog if you come near alcohol - used to maintain alcohol abstinence-- (aldehyde dehydrogenase)
Name an agonist of the benzodiazepine site on the GABA A receptor that ameliorates some of the sequelae of alcohol withdrawalGABA

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