Neuropharmacology Part III

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Can you name the drugs matching each description?

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DescriptionDrugNeurotransmitter involved
Name an anti-VEGF antibody that can treat wet age-related macular degeneration by blocking blood vessel formation behind the retina-- (VEGF)
Name an agonist of the benzodiazepine site on the GABA A receptor that ameliorates some of the sequelae of alcohol withdrawalGABA
Name a drug that causes acetaldehyde buildup (inhibits aldehyde dehydrogenase) and makes you sick as a dog if you come near alcohol - used to maintain alcohol abstinence-- (aldehyde dehydrogenase)
Name a novel antidepressant that has little to no effect on serotonin uptakeDopamine or Serotonin (but not reuptake)
Name the benzodiazepine used for insomnia with the shortest 1/2 life - good for people who need to be alert in the morningGABA
Name the classic drug for the treatment of bipolar disorder that inhibits the hydrolysis of inositol-1-phosphate-- (Inositol-1-monophosphate)
Name an agonist of the 5-HT 1A receptor that reduces some 5-HT neuron firing. Treats generalized anxiety, anxiety with depressionSerotonin
Name a first choice non-BZ GABA A agonist drug for insomnia with an intermediate half lifeGABA
Name a drug combination (name two drugs or the trade name of the combo) of an antidepressant and an antipsychotic used to treat bipolar disorder. Use '+' or 'and' to separateDopamine, Serotonin
Name a short-acting muscarinic receptor antagonist used to dilate the pupils for an eye examAcetylcholine
Name a 5-HT transport inhibitor with alpha 2 agonist and H1 antagonist activity that treats depression and insomniaSerotonin
Name a long-acting muscarinic receptor that produces long-lasting mydriasis and cycloplegia for a prolonged eye examAcetylcholine
Name a carbonic anhydrase inhibitor that reduces aqueous humour production (eyedrops)-- (HC03-)
Name a beta 1/beta 2 receptor antagonist that treats glaucoma by reducing aqueous humour production (eyedrops)Epinephrine, Norepinephrine
DescriptionDrugNeurotransmitter involved
Name a D2-like receptor antagonist used to treat the positive symptoms of schizophrenia (not the negative ones)Dopamine
Name an addictive drug that most adults use that potentiates GABA A receptors and depresses NMDA receptorsGABA, Glutamate
Name a melatonin receptor agonist used to treat insomnia; interaction only with a particular SSRIMelatonin
Name a drug that inhibits reuptake of both 5-HT and NE; treats depression, generalized anxiety, panic disorder, social phobia, PTSDSerotonin, Norepinephrine
*NOT ON DRUG LIST - FROM LECTURE* Name a drug in eyedrops that causes constriction of the ciliary muscles to open the trabecular meshwork (serious miosis)Acetylcholine
Name a drug typically considered an anticonvulsant that is also indicated for treatment of bipolar disorder-- (Na+)
Name an SSRI that treats depression by increasing serotonin in the synaptic cleftSerotonin
Name an alpha 2 receptor agonist that reduces aqueous humour production (eyedrops)Norepinephrine, Epinephrine
Name a benzodiazepine, which potentiates the activity of the GABA A receptor, used to treat anxietyGABA
Name a drug used to treat alcohol addiction that is a glutamate antagonist and increases GABA releaseGlutamate, GABA
*NOT ON DRUG LIST - FROM LECTURE* Name a drug in eyedrops that produces mydriasis as an alpha 1 receptor agonist (causes vasoconstriction, too)Epinephrine, Norepinephrine
Name a D2-like receptor, 5-HT2 receptor antagonist used to treat the + and - symptoms of schizophreniaDopamine, Serotonin
Name a prostaglandin analogue, an agonist of the FP receptor that increases aqueous humour outflow through the uveoscleral route (eyedrops)Prostaglandin

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