Neuropharmacology Part II

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Can you name the drugs matching each description?

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DescriptionDrugNeurotransmitter involved
Name one of two muscarinic receptor antagonists used to treat Parkinson's disease by blocking the tremor circuit, increasing the direct pathway, and decreasing the indirect pathwayAcetylcholine
Name a peripheral mu receptor agonist that is available over the counter for its anti-diarrheal effects because it does not enter the CNSOpioids
This drug, indicated for generalized tonic-clonic and partial seizures, increases GABA concentration in the CNS by acting as a GABA aminotransferase inhibitorGABA
Name any of three anti-seizure drugs indicated for generalized tonic-clonic and partial seizures, but NOT migraines or absence seizures. Stabilize inactive Na channels-- (Na+)
Name one of two drugs, MAO-B inhibitors, that increase DA in the basal ganglia and are used to treat Parkinson's disease early onDopamine
Name a benzodiazepine used to sedate patients and produce amnesia in preoperative patients GABA
Name the class of drugs that blocks both forms of cyclooxygenase and thereby reduces prostaglandin levels to reduce painProstaglandins
Name one of two narcotic drugs given for postoperative outpatient analgesia, Combination with acetaminophen permits use of lower narcotic doses of these drugsOpioids
This is an opiate formerly used to control cough that has since fallen out of favor. A partial mu agonist, it suppresses the cough reflex.Opioids
This opiate is an addictive drug that can be snorted, injected, or smoked. It acts as a mu receptor agonist and activates the dopamine reward pathway.Opioids
Name a long-acting mu/delta/kappa receptor antagonist that is used in treatment of alcoholism to block the euphoric effects produced by endogenous opioids when alcohol is consumedOpioids
Name the drug (or its commercial preparations with peripheral metabolic inhibitors) used to treat Parkinson's by increasing DA in the basal ganglionDopamine
This drug is a low-affinity NMDA blocker that reduces dyskinesia induced by treatment of Parkinson's diseaseGlutamate
Name a drug that blocks NMDA channels to produce dissociative amnesia while sparing opioid receptors (prevents anti-analgesic effect of fentanyl after many high doses)Glutamate
Name one of two D2 receptor agonists used to treat Parkinson's disease by reducing activity in the indirect pathwayDopamine
Name one of two anti-seizure drugs that increase GABA receptor function to increase amplitude or duration of IPSPs. These drugs treat generalized tonic-clonic and partial seizuresGABA
Name one of two drugs that prevent generalized tonic-clonic and partial seizures by binding the gamma regulatory subunit of voltage-gated calcium channels-- (Ca++)
Name one of four drugs that are effective in preventing neuropathic pain as well as treating epilepsy due to their effects on ion channels (sodium, calcium)-- (Na+, Ca++)
Name an inhaled anesthetic that works by indirect ion channel perturbation-- (ion channels)
DescriptionDrugNeurotransmitter involved
Name a lipophilic mu receptor agonist given in lollipops to children for pre-operative anesthesiaOpioids
Name a drug that increases GABA A receptor function and induces general anesthesiaGABA
This is one of the two opiates, not opiods, used in clinical practice. This one can be adminstered as an IV drip and has more clinical efficacy than the other.Opioids
Name a kappa receptor agonist (and partial mu receptor agonist) that provides analgesia without euphoria (and makes the patient feel pretty cruddy, like going through withdrawal). Opioids
This anti-seizure drug works on sodium channels but has efficacy against generalized tonic-clonic, partial, AND absence seizures-- (Na+)
Name the drug (or its combination formulations with naloxone) that is a partial mu agonist/kappa antagonist used to maintain abstinence from narcoticsOpioids
This drug is indicated for absence seizures. It works by inhibiting low threshold calcium current, preventing bursts of discharge from the thalamic relay neurons-- (Ca++)
Name an anti-seizure drug for all seizure types with mechanisms of action including inhibition of sodium channels, GABA metabolism, and low-threshold calcium currentGABA (Na+, Ca++)
Name a very mild partial mu agonist that also blocks NE and 5-HT reuptake that treats mild to moderate pain without the dependence and abuse liability of full mu agonistsOpioids, Norepinephrine, Serotonin
This drug is a GABA transport inhibitor that increases extracellular GABA in the CNS, preventing generalized tonic-clonic and partial seizuresGABA
This lipophilic mu receptor agonist is not available in an oral form, but is faster-acting and more potent than the drug from which it is derived. Pre-operative anesthesiaOpioids
Name the peripheral COMT inhibitor used to increase delivery of dopamine precursors to the CNSDopamine
Name a local anesthetic - you should know why and how they work on pain-- (Na+)
Name the drug (or trade name) that John Travolta should have given Uma Thurman in Pulp Fiction; it acts as a mu/delta/kappa competitive antagonist and blocks all opioid activityOpioids
Name an anti-seizure drug that prevents generalized tonic-clonic and partial seizures as well as migraines by stabilizing inactivated sodium channels-- (Na+)
This anti-seizure drug binds SV2A synaptic vesicle protein and is thought to inhibit excessive neurotransmitter release, preventing generalized tonic-clonic and partial seizuresMultiple
Name the peripheral DOPA decarboxylase inhibitor used to increase delivery of dopamine precursors to the CNSDopamine
This narcotic is slow acting and long-acting; while its low, extended levels of activity are good for narcotic abstinence and chronic pain, overdose is a big riskOpioids
Name one of the two drugs used for their activity as peripheral mu receptor antagonists, reversing narcotic-induced constipationOpioids

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