| Character | Actor |
|---|
| Jimmy McNulty | |
| William 'Bunk' Moreland | |
| Kima Greggs | |
| Lester Freamon | |
| Bill Rawls | |
| Ervin Burrell | |
| Cedric Daniels | |
| Reginald 'Bubbles' Cousins | |
| Rhonda Pearlman | |
| Avon Barksdale | |
| Russell 'Stringer' Bell | |
| D'Angelo Barksdale | |
| Frank Sobotka | |
| Spiros 'Vondas' Vondopoulos | |
| Beatrice 'Beadie' Russell | |
| Tommy Carcetti | |
| Roland 'Prez' Pryzbylewski | |
| Howard 'Bunny' Colvin | |
| | Character | Actor |
|---|
| Ellis Carver | |
| Thomas 'Herc' Hauk | |
| Omar Little | |
| Preston 'Bodie' Broadus | |
| Leander Sydnor | |
| Dennis 'Cutty' Wise | |
| Marlo Stanfield | |
| Clarence Royce | |
| Norman Wilson | |
| Chris Partlow | |
| Michael Steintorf | |
| Duquan 'Dukie' Weems | |
| Michael Lee | |
| Maurice Levy | |
| Gus Haynes | |
| Scott Templeton | |
| Alma Gutierrez | |
| Clay Davis | |
|
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