| Air Date and Host | Musical Guest |
| January 22, 2005 Paul Giamatti | |
| February 5, 2005 Paris Hilton | |
| February 12, 2005 Jason Bateman | |
| February 19, 2005 Hilary Swank | |
| March 12, 2005 David Spade | |
| March 19, 2005 Ashton Kutcher | |
| April 9, 2005 Cameron Diaz | |
| April 16, 2005 Tom Brady | |
| May 7, 2005 Johnny Knoxville | |
| May 14, 2005 Will Ferrell | |
| May 21, 2005 Lindsay Lohan | |
| October 1, 2005 Steve Carrell | |
| October 8, 2005 Jon Heder | |
| October 22, 2005 Catherine Zeta-Jones | |
| October 29, 2005 Lance Armstrong | |
| November 12, 2005 Jason Lee | |
| November 19, 2005 Eva Longoria Parker | |
| December 3, 2005 Dane Cook | |
| December 10, 2005 Alec Baldwin | |
| December 17, 2005 Jack Black | |
| January 14, 2006 Scarlett Johansson | |
| January 21, 2006 Peter Sarsgaard | |
| Februrary 4, 2006 Steve Martin | |
| March 4, 2006 Natalie Portman | |
| March 11, 2006 Matt Dillon | |
| April 8, 2006 Antonio Banderas | |
| April 15, 2006 Lindsay Lohan | |
| May 6, 2006 Tom Hanks | |
| May 13, 2006 Julia Louis-Dreyfus | |
| May 20, 2006 Kevin Spacey | |
| September 30, 2006 Dane Cook | |
| October 7, 2006 Jaime Pressly | |
| | Air Date and Host | Musical Guest |
| October 21, 2006 John C. Reilly | |
| October 28, 2006 Hugh Laurie | |
| November 11, 2006 Alec Baldwin | |
| November 18, 2006 Ludacris | |
| December 2, 2006 Matthew Fox | |
| December 9, 2006 Annette Bening | |
| December 16, 2006 Justin Timberlake | |
| January 13, 2007 Jake Gyllenhaal | |
| January 20, 2007 Jeremy Piven | |
| Februrary 3, 2007 Drew Barrymore | |
| February 10, 2007 Forest Whitaker | |
| February 24, 2007 Rainn Wilson | |
| March 17, 2007 Julia Louis-Dreyfus | |
| March 24, 2007 Peyton Manning | |
| April 14, 2007 Shia LeBeouf | |
| April 21, 2007 Scarlett Johansson | |
| May 12, 2007 Molly Shannon | |
| May 19, 2007 Zach Braff | |
| September 29, 2007 LeBron James | |
| October 6, 2007 Seth Rogen | |
| October 13, 2007 Jon Bon Jovi | |
| November 3, 2007 Brian Williams | |
| February 23, 2008 Tina Fey | |
| March 1, 2008 Ellen Page | |
| March 8, 2008 Amy Adams | |
| March 15, 2008 Jonah Hill | |
| April 5, 2008 Christopher Walken | |
| April 12, 2008 Ashton Kutcher | |
| May 10, 2008 Shia LaBeouf | |
| May 17, 2008 Steve Carrell | |
| September 13, 2008 Michael Phelps | |
| September 20, 2008 James Franco | |
| | Air Date and Host | Musical Guest |
| September 27, 2008 Anna Faris | |
| October 4, 2008 Anne Hathaway | |
| October 18, 2008 Josh Brolin | |
| October 25, 2008 Jon Hamm | |
| November 1, 2008 Ben Affleck | |
| November 15, 2008 Paul Rudd | |
| November 22, 2008 Tim McGraw | |
| December 6, 2008 John Malkovich | |
| December 13, 2008 Hugh Laurie | |
| January 10, 2009 Neil Patrick Harris | |
| January 17, 2009 Rosario Dawson | |
| January 31, 2009 Steve Martin | |
| February 7, 2009 Bradley Cooper | |
| February 14, 2009 Alec Baldwin | |
| March 7, 2009 Dwayne Johnson | |
| March 14, 2009 Tracy Morgan | |
| April 4, 2009 Seth Rogen | |
| April 11, 2009 Zac Efron | |
| May 9, 2009 Justin Timberlake | |
| May 16, 2009 Will Ferrell | |
| September 26, 2009 Megan Fox | |
| October 3, 2009 Ryan Reynolds | |
| October 10, 2009 Drew Barrymore | |
| October 17, 2009 Gerard Butler | |
| November 7, 2009 Taylor Swift | |
| November 14, 2009 January Jones | |
| November 21, 2009 Joseph Gordon-Levitt | |
| December 5, 2009 Blake Lively | |
| December 12, 2009 Taylor Lautner | |
| December 19, 2009 James Franco | |
|