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Cell Signalling and Protein Transport
Can you name the Cell Signalling and Protein Transport Components from Bio 2B03?
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Peroxisomal Protein Targeting
Cytosolic protein that recognizes the PTS1 targetting sequence
Peroxisome membrane protein, receptor for [above]
Amino acid sequence of the PTS1 signal peptide, found at the extreme C-terminus
A monomer of the protein translocon channel (name any)
Protein responsible for peroxisome membrane biogenesis
Mitochondrial Protein Targeting
Sequence recognized by the mitochondrial import receptor; has an amphipathic helix
Any monomer of the mitochondrial import receptor
Facilitates protein movement from cytoplasm to intermembrane space
Translocon connecting intermembrane space and matrix
ATP-dependent chaperone that keeps polypeptides unfolded
Type of sequence that targets a protein to the inner membrane
Unfolded Protein Response
Binds to unfolded proteins
Forms a dimer when [above] dissociates
Transcription factor that upregulates UPR proteins
A type of unfolded protein response enzyme
ER Protein Targeting
Protein that recognizes a 16-30 N-terminal residue that has a positive, hydrophobic, and polar domain, from the N to C terminus direction.
Alpha subunit of this protein binds to [above]
Generic name for a membrane protein that allows a protein to pass through a membrane; binds to beta subunit of [above]
ER membrane protein that cleaves signal sequences of proteins that have passed into the ER lumen
Type of sequence required to integrate protein into ER membrane, with N-terminal in lumen (Type I)
Type of sequence required to integrate protein in ER membrane, with C terminal in lumen (Type II) [or, N terminal in lumen with bulk of the protein on the cytosol side (type III)]
COPII Vesicle Formation
GTP-ase that anchors to ER membrane when activated with GTP
Equivalent for [above] in the COPI or clathrin vesicle formation model
Membrane protein that is a receptor for [two above]
One of the COPII coat proteins
G-protein that releases the vesicle from the membrane
GTPase that binds to a vesicle to control its docking
Interacts with [above] to bring vesicles to target membrane
Complex that links vesicle to target membrane
Red Blood Cell Formation
Cytokine that signals bone marrow cells to reproduce
Receptor for [above]; dimerizes when bound to signal protein.
Bound to [above]; Phosphorylated when [above] is dimerized, and promotes phosphorylation of receptor to form docking site for [below]
Transcription factor that regulates genes such as Bcl-XL that prevent cell death of bone marrow cells.
Sequence exposed in [above] when phosphorylated and dimerized.
Domain of a protein that recognizes phosphorylated tyrosines
Phosphatase that deactivates pathway for short-term regulation
Protein that recruits [below] to degrade receptor proteins for long-term regulation
Enzyme that marks a protein for degradation
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