Science / Dr. Smith's Final Drugs

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Can you name the Dr. Smith's Final Drugs?

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DescriptionDrug
If this drug is dosed >7mg/kg, then it becomes an oxidant
Blocks electron flow from cytochrome bH to ubiquinone.
Suicide inhibitor of xanthine oxidase
Carboxylation of glutamate to carboxyglutamate in prothrombin requires the enzyme ________ and cofactor _________
Antibiotic that directly binds to ATP synthase and inhibits both ATP synthesis and the transfer of electrons through the electron transport chain
Herpes treatment
a prodrug of mycophenolic acid (MPA)
Relieves symptoms of gout
Anti-coagulant, binds to ant-thrombin which leads to a conformation change allowing anti-thrombin to bind to thrombin, which inactivates it, inhibiting the activation of fibrinogen
Anticancer and rheumatoid arthritis agent that affects both DNA synthesis and de novo purine synthesis
inhibits IMP dehydrogenase (IMP --> XMP [de novo pathway])
Binds bacterial/protozoal dihydrofolate reductase proteins 10^5 more tightly than human DHFR
Used to treat acetaminophen overdose
Competitively inhibits dihydrofolate reductase and prevents the regeneration of tetrahydrofolate
cytostatic against lymphocytes which almost entirely lack purine salvage and depend on de novo pathway for purines
Covalently binds to transpeptidase thus prevents synthesis of bacterial cell walls. Suicide inhibitor.
Works by increasing the blood concentration of fetal hemoglobin
Drug used to treat sickle cell disease
inhibitor of pancreatic lipase
prevents the necessary 1,3 hydride shift to reduce the CH2 to CH3 on methylenetetrahyrdofolate
Its mechanism is to increase glutathione levels by supplying cysteine for the synthesis of glutathione
Inactivated by xanthine oxidase and thiopurine methyltransferase (TPMT).
non-prescription form of Orlistat
Common treatment for methemoglobinemia
DescriptionDrug
Inhibits inducible nitric oxide synthase
Large, bulky molecules;unable to bind to COX-1
peroxynitrite [ONOO-] scavenging compound
Inhibits the production of prostaglandins;irreversible inhibitor
Has a modified sugar which has 2 fluorine atoms at the 2' position rather than 2 hyrdogens. Can be twice phosphorylated by deoxycytidine kinase and then dCMP kinase and acts as a s
An anti-inflammatory drug metabolized in the colon by intestinal bacteria to produce 5-aminosalicylic acid
Combined antibiotic - sulfamethoxazole and trimethoprim
used as an immunosuppressant in organ transplants and in patients with inflammatory bowel disease
similar structure to vitamin K and competitively inhibits carboxylase.
prodrug of 6-mercaptopurine
It binds to the toxic metabolite (forming mercapturic acid) for excretion in the urine
structure similar to dihydrofolate, thus can be a competitive inhibitor of dihydrofolate reductase.
Nucleotide analog of deoxcycytidine used in treatment of pancreatic cancer
decrease efficiency of fat-soluble vitamin absorption due to their effect on bile acids.
converted to the deoxynucleotide, which inhibits cell division.
Induces hemolysis in patients with glucose 6-phosphate dehydrogenase deficiency
Is converted to fluorodeoxyuridylate (has a similar structure to deoxyuridylate), which irreversibly inhibits thymidylate synthase - suicide inhibition.
Inhibits cyclooxygenase by acetylating the serine residue that lies along the path to the active site and blocks the channel
Inhibitor of pancreatic lipase, side effects are GI problems
Analog of uracil used to treat breast and colorectal cancer.
Phosphorylated by human kinases but selectively interfere with viral replication. Both have modified sugars that lack 3; OH group and in effect terminates DNA synthesis
Inhibits the electron flow from the Fe-S centers of Complex I to ubiquinone, thus blocking oxidative phosphorylation
can also inhibit folate absorption by preventing the excess glutamates from being cleaved off
Inhibits TMP production by preventing the regeneration of methylene-THF; used as an anticancer agent and in the treatment of rheumatoid arthritis
DescriptionDrug
competitively inhibiting HMG CoA reductase to inhibit endogenous cholesterol synthesis
Bind bile acids, thus decrease absorption of exogenous (dietary) cholesterol.
Binds at ubiquinone binding site that is close to cytochrome bH on the matrix side membrane
Inhibits alpha-amylase, alpha-dextrinase, maltase, and sucrase
Increases cytochrome b5 reductase
Marketed by Roche as CellCept(R)
An alpha-glucosidase inhibitor. It delays carbohydrate digestion in the small intestines and thus decreases blood glucose in Diabetics (type II)
Anti cancer drug, can block the synthesis of thymidylate
Inhibits oxidative phosphorylation by binding to one of the ubiquinone binding sites on Complex III
Selective COX-2 inhibitor
It catalyzes the conversion of arachidonic acid to prostaglandins
Side effects: gastrointestinal problems due to fermentation of carbohydrates in large intestines and water holding capacity of the disaccharides.
the committed step of its reaction is the inhibition of the conversion of PRPP into PR-amine
Converted to alloxanthine which binds tightly with xanthine oxidase, which decreases urate production and xanthine and hypoxanthine concentrations rise
Suicide inhibitor; is converted into FdUMP and forms a covalent intermediate with thymidylate synthase that cannot be reversed
Inhibits bacterial synthesis of folate
Anticoagulant, similar to warfarin, which prevents the formation to carboxyglutamate in prothrombin.
Associated with inflammation, cancer, colitis, and arthritis
Phosphorylated by viral encoded thymidine kinase but not human thymidine kinase. Only infected cells efficiently phosphorylate the drugs, which then inhibit DNA replication
Used in treatment of inflammatory bowel disease.
Vasodilator which releases NO
inhibits cell division in a similar manner as 6-mercaptopurine and is also inactivated by thiopurine methyltranserfase

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