| Route | City |
|---|
| I-5 between Los Angeles and Seattle | |
| I-80 between Chicago and Cheyenne | |
| I-15 between Las Vegas and Canadian border (Sunburst, MT) | |
| I-95 between New York and Miami | |
| I-70 between Baltimore and Indianapolis | |
| I-29 between Sioux Falls and Canadian border (Pembina, ND) | |
| I-75 between Tampa and Mackinac Bridge (Mackinaw City, MI) | |
| I-94 between Milwaukee and St. Paul | |
| I-10 between San Antonio and Phoenix | |
| I-65 between Nashville and Indianapolis | |
| I-35 between Kansas City and Minneapolis | |
| I-77 between Columbia, SC and Charleston, WV | |
| I-44 between Oklahoma City and St. Louis | |
| I-20 between Dallas and Atlanta | |
| I-40 between Winston-Salem and Flagstaff | |
| I-90 between Seattle and Boston | |
| I-85 between Montgomery and Spartanburg | |
| I-55 between Joliet and Memphis | |
| I-25 between Las Cruces and Denver | |
| I-64 between Louisville and Richmond | |
Largest Second Place Cities
Cities of New England
Landlocked Cities
