Exam 9 Drugs

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Can you name the Exam 9 Drugs?

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MechanismDrugDisease or Use
Decreased hepatic glucose production, potentiation of insulin action in peripheral tissues by increasing cell surface insulin receptors, increasing Glut4 glucose transporters and iType 2 diabetes
Estrogen receptor agonistsContraception, infertility, prostate cancer, HRT
Progesterone receptor antagonistsPregnancy termination
Short-acting KATP channel blockers, increase insulin secretionType 2 diabetes
V2 receptor agonist, replace or supplement vasopressionDiabetes insipidus, nocturnal enuresis
D2 receptor agonist/weak D1 receptor antagonist, intended to reduce the secretion of growth hormone or prolactinAcromegaly, gigantism, hyperprolactinemia
Somatostatin receptor agonists, intended to reduce the secretion of growth hormone in response to any stimulusAcromegaly, gigantism
5-α reductase inhibitors, inhibit production of dihydrotestosteroneBPH, male pattern baldness
Growth hormone receptor antagonist, most effective therapy for normalization of IGF-1Acromegaly, gigantism
V2 receptor antagonistHyponatremia
Estrogen receptor agonists in bone, antagonists in breast, uterus, and brainBreast cancer (treatment and prevention), osteoporosis
Estrogen receptor partial agonist in brainInfertility
Concentration in and destruction of thyroid tissueHyperthyroidism
Replace or supplement T3Myxedema coma
Inhibition of thyroid hormone synthesis and release,Hyperthyroidism preparative to thyroidectomy, reduction of thyroid gland vascularity, reduction of thyroid cell proliferation
Androgen receptor agonistsInfertility, hypogonadism, muscle wasting/atrophy, erythropoiesis, HRT (men), endometriosis
Progesterone receptor agonistsContraception, emergency contraception, endometriosis, dysfunctional uterine bleeding, hormone-refractory breast cancer, HRT (without hysterectomy)
MechanismDrugDisease or Use
Long-acting KATP channel blocker, increases insulin secretionType 2 diabetes
V1A,V2 receptor antagonistHyponatremia
Androgen receptor antagonistProstate cancer
Alternate substrate for thyroperoxidase, inhibition of thyroxin synthesis, inhibition of coupling to form thyroglobulinHyperthyroidism (except during pregnancy and breast feeding)
GnRH receptor agonists, intended to block testosterone secretion through downregulation of pituitary GnRH receptorsProstate cancer
Estrogen receptor agonist in bone and uterus, antagonist in breast and brainBreast cancer (treatment and prevention)
Supplement oxytocinInitiation or improvement of uterine contractions in labor or incomplete abortion, control of postpartum bleeding
Cyp 17,20 lyase inhibitor, inhibit production of testosteroneProstate cancer
GLP-1 agonist; potentiation of insulin secretion, inhibition of glucagon secretionType 2 diabetes
Activation of peroxisome proliferator-activated receptors (PPAR), increase in insulin-stimulated rate of glucose utilization, reduced lipolysis and increased fat storage, reduced cType 2 diabetes
Alternate substrate for thyroperoxidase, inhibition of thyroxin synthesis, inhibition of coupling to form thyroglobulin, inhibition of T4®T3Hyperthyroidism (especially during pregnancy and breast feeding)
Replace or supplement growth hormonePrimary growth hormone deficiency, Turner’s Syndrome, Prader-Willi syndrome, Chronic growth retarding disease, Idiopathic short stature, Chronic renal insufficiency, AIDS wasting syndrome
DPP-IV inhibitor; slows breakdown of GLP-1 and GIPType 2 diabetes
Replace or supplement insulinType 1 and type 2 diabetes
Analogue of amylin (a small peptide normally released from beta cells along with insulin); slows gastric emptying, promotes satiety, inhibits glucagon secretionType 1 and type 2 diabetes
Replace or supplement T4Hypothyroidism

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