Exam 6 Drugs

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Can you name the Exam 6 Drugs?

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MechanismDrugDisease / Use
Inhibition of cyclo-oxygenases, intended to block production of inflammatory prostaglandinsInflammatory pain, prevention of neuropathic pain
Peripheral µ receptor antagonists, intended to reverse narcotic-induced constipationNarcotic-induced constipation
Inhaled glucocorticoid + rapidly-acting, long duration β2 agonistAsthma prophylaxis (Steps 3-6), prophylaxis for COPD that includes chronic bronchitis
β1/β2 antagonist, reduces the production of aqueous humourOpen angle glaucoma
Muscarinic antagonistBest prophylaxis for COPD
Carbonic anhydrase inhibitor, reduces the production of aqueous humourOpen angle glaucoma
Slow-acting, long duration β2 agonist (long-lasting bronchodilation with some anti-inflammatory activity of uncertain utility)Use only as Advair
Bind γ regulatory subunit of voltage-gated calcium channels, others?Prevention of generalized tonic-clonic and partial seizures
Analogue of prostaglandin F2α, agonist for FP receptor, increases outflow of aqueous humour through the uveoscleral routeOpen angle glaucoma
µ receptor agonists, intended to depress spinal cord and brain pain pathways (highly lipophilic)Pre- and intra-operative analgesia
µ receptor agonists, intended to depress spinal cord and brain pain pathways and the cough reflexPostoperative outpatient analgesia, chronic pain, cough
µ receptor agonist, activates the dopamine reward pathwayAddictive drug
Rapidly-acting, short duration β2 agonist (bronchodilation)Acute asthmatic attack (Steps 1-6)
H1/muscarinic antagonist Allergy, insomnia, motion sickness, symptoms of upper respiratory infection
Binds SV2A synaptic vesicle protein, modulates excessive transmitter releasePrevention of generalized tonic-clonic and partial seizures
Stabilizes inactivated state of sodium channel, inhibits GABA metabolism, inhibits low threshold calcium current, inhibits HDAC, others?Prevention of generalized tonic-clonic, partial, and absence seizures
Stabilize inactivated state of the sodium channel/prevent high frequency firing or bind γ regulatory subunit of voltage-gated calcium channelsNeuropathic pain
µ/δ/κ receptor competitive antagonist, blocks all effects of endogenous opioids and narcoticsNarcotic overdose
H1 antagonistAllergy
GABA transport inhibitor, intended to increase extracellular GABA concentration in CNSPrevention of generalized tonic-clonic and partial seizures
µ receptor agonist, intended to depress spinal cord and brain pain pathwaysPostoperative analgesia in hospital, end-of-life analgesia
Inhibition of low threshold calcium current, intended to prevent burst discharge of thalamic relay neuronsPrevention of absence seizures
Indirect perturbation of ion channel functionGeneral inhalation anesthetics
κ receptor agonist, partial µ receptor agonistAnalgesia without euphoria
Stabilize inactivated state of sodium channel, prevent high frequency firingPrevention of generalized tonic-clonic and partial seizures
Partial µ receptor agonist, occupies µ receptors in the reward pathwayMaintain abstinence from narcotics
Inhaled glucocorticoid + slow-acting, long duration β2 agonistAsthma prophylaxis (Steps 3-6), prophylaxis for COPD that includes chronic bronchitis
MechanismDrugDisease / Use
Stabilize inactivated state of sodium channel, prevent high frequency firingPrevention of generalized tonic-clonic, partial, and absence seizures
Rapidly-acting, long duration β2 agonist (long-lasting bronchodilation with some anti-inflammatory activity of uncertain utility)Use only as Symbicort
Agonists of benzodiazepine site on GABAA receptorSedation and amnesia
Reversible anticholinesterase, intended to prevent hydrolysis of ACh in peripheryTerminate action of non-depolarizing neuromuscular blocking agents
Inhaled glucocorticoid (inhibition of mast cell mediator synthesis, reduced leukocyte chemotaxis, up regulation of β2 receptor number and agonist sensitivity)Asthma prophylaxis (Steps 2-6)
Block of NMDA channelDissociative anesthesia
Muscarinic antagonist, intended to produce brief mydriasisPreparing the eye for examination
Monoclonal antibody against IgEAsthma-allergy prophylaxis (Consider Steps 5-6)
Humanized monoclonal antibody against VEGF, intended to block blood vessel formation behind the retinaWet age-related macular degeneration
µ receptor agonist, intended to depress spinal cord and brain pain pathways and to occupy µ receptors in the reward pathway Chronic pain, maintain abstinence from narcotics
α2 agonist, reduces the production of aqueous humour, increases outflow of aqueous humour through the uveoscleral routeOpen angle glaucoma
Rapidly-acting, short duration β2 agonist + muscarinic antagonist (longer bronchodilation than achievable with albuterol alone) Severe acute asthmatic attack (Steps 1-6), acute bronchoconstriction in COPD
CysLT1 antagonist (bronchodilation and anti-inflammatory activity)Asthma prophylaxis (Alternative Steps 2-4, add-on Step 5), chronic allergy
Skeletal muscle nicotinic receptor agonist, relax skeletal muscles during surgery through depolarization blockDepolarizing neuromuscular blocking agent
Oral glucocorticoid (inhibition of mast cell mediator synthesis, reduced leukocyte chemotaxis, up regulation of β2 receptor number and agonist sensitivity)Used after albuterol for acute asthmatic attack, asthma prophylaxis (Step 6)
Partial µ receptor agonist, intended to depress the cough reflexCough
Increase GABAA receptor function, increase amplitude or duration of IPSPs in CNSPrevention of generalized tonic-clonic and partial seizures
Increase GABAA receptor functionInduction of general anesthesia
Block of sodium channel, preferentially block firing in pain fibers (know why)Local anesthetics
Peripheral µ receptor agonist, intended to reduce peristalsisDiarrhea
Glucocorticoid nasal sprays (inhibition of mast cell mediator synthesis, reduced leukocyte chemotaxis)Chronic nasal allergy
α1 agonists, heteroexchange with NE (vasoconstriction)Nasal allergy
Inhibits PDE4 (bronchodilation and anti-inflammatory activity)Asthma prophylaxis (Alternative Steps 2-4, add-on Step 5)
Partial µ receptor agonist, inhibits NE/5-HT transportMild pain
Muscarinic antagonist, intended to produce longer-lasting mydriasis and cycloplegiaPreparing the eye for prolonged examination, diagnosis of refractive errors in children
GABA aminotransferase inhibitor, intended to increase GABA concentration in CNSPrevention of generalized tonic-clonic and partial seizures
Skeletal muscle nicotinic receptor antagonists, relax skeletal muscles during surgeryNon-depolarizing neuromuscular blocking agents

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