Just For Fun / Exam 6 Drugs

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Can you name the Exam 6 Drugs?

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MechanismDrugDisease / Use
Stabilize inactivated state of sodium channel, prevent high frequency firingPrevention of generalized tonic-clonic, partial, and absence seizures
µ receptor agonists, intended to depress spinal cord and brain pain pathways (highly lipophilic)Pre- and intra-operative analgesia
Muscarinic antagonistBest prophylaxis for COPD
Peripheral µ receptor agonist, intended to reduce peristalsisDiarrhea
Rapidly-acting, long duration β2 agonist (long-lasting bronchodilation with some anti-inflammatory activity of uncertain utility)Use only as Symbicort
Inhibition of cyclo-oxygenases, intended to block production of inflammatory prostaglandinsInflammatory pain, prevention of neuropathic pain
Increase GABAA receptor function, increase amplitude or duration of IPSPs in CNSPrevention of generalized tonic-clonic and partial seizures
α2 agonist, reduces the production of aqueous humour, increases outflow of aqueous humour through the uveoscleral routeOpen angle glaucoma
Stabilize inactivated state of sodium channel, prevent high frequency firingPrevention of generalized tonic-clonic and partial seizures
Rapidly-acting, short duration β2 agonist (bronchodilation)Acute asthmatic attack (Steps 1-6)
Inhaled glucocorticoid (inhibition of mast cell mediator synthesis, reduced leukocyte chemotaxis, up regulation of β2 receptor number and agonist sensitivity)Asthma prophylaxis (Steps 2-6)
Reversible anticholinesterase, intended to prevent hydrolysis of ACh in peripheryTerminate action of non-depolarizing neuromuscular blocking agents
Peripheral µ receptor antagonists, intended to reverse narcotic-induced constipationNarcotic-induced constipation
Increase GABAA receptor functionInduction of general anesthesia
Oral glucocorticoid (inhibition of mast cell mediator synthesis, reduced leukocyte chemotaxis, up regulation of β2 receptor number and agonist sensitivity)Used after albuterol for acute asthmatic attack, asthma prophylaxis (Step 6)
µ receptor agonists, intended to depress spinal cord and brain pain pathways and the cough reflexPostoperative outpatient analgesia, chronic pain, cough
α1 agonists, heteroexchange with NE (vasoconstriction)Nasal allergy
Stabilize inactivated state of the sodium channel/prevent high frequency firing or bind γ regulatory subunit of voltage-gated calcium channelsNeuropathic pain
Monoclonal antibody against IgEAsthma-allergy prophylaxis (Consider Steps 5-6)
µ receptor agonist, activates the dopamine reward pathwayAddictive drug
Glucocorticoid nasal sprays (inhibition of mast cell mediator synthesis, reduced leukocyte chemotaxis)Chronic nasal allergy
H1 antagonistAllergy
Stabilizes inactivated state of sodium channel, inhibits GABA metabolism, inhibits low threshold calcium current, inhibits HDAC, others?Prevention of generalized tonic-clonic, partial, and absence seizures
Partial µ receptor agonist, occupies µ receptors in the reward pathwayMaintain abstinence from narcotics
CysLT1 antagonist (bronchodilation and anti-inflammatory activity)Asthma prophylaxis (Alternative Steps 2-4, add-on Step 5), chronic allergy
Carbonic anhydrase inhibitor, reduces the production of aqueous humourOpen angle glaucoma
µ receptor agonist, intended to depress spinal cord and brain pain pathways and to occupy µ receptors in the reward pathway Chronic pain, maintain abstinence from narcotics
MechanismDrugDisease / Use
GABA aminotransferase inhibitor, intended to increase GABA concentration in CNSPrevention of generalized tonic-clonic and partial seizures
Agonists of benzodiazepine site on GABAA receptorSedation and amnesia
GABA transport inhibitor, intended to increase extracellular GABA concentration in CNSPrevention of generalized tonic-clonic and partial seizures
µ receptor agonist, intended to depress spinal cord and brain pain pathwaysPostoperative analgesia in hospital, end-of-life analgesia
Muscarinic antagonist, intended to produce longer-lasting mydriasis and cycloplegiaPreparing the eye for prolonged examination, diagnosis of refractive errors in children
Skeletal muscle nicotinic receptor antagonists, relax skeletal muscles during surgeryNon-depolarizing neuromuscular blocking agents
κ receptor agonist, partial µ receptor agonistAnalgesia without euphoria
Slow-acting, long duration β2 agonist (long-lasting bronchodilation with some anti-inflammatory activity of uncertain utility)Use only as Advair
Binds SV2A synaptic vesicle protein, modulates excessive transmitter releasePrevention of generalized tonic-clonic and partial seizures
Inhaled glucocorticoid + slow-acting, long duration β2 agonistAsthma prophylaxis (Steps 3-6), prophylaxis for COPD that includes chronic bronchitis
Inhibits PDE4 (bronchodilation and anti-inflammatory activity)Asthma prophylaxis (Alternative Steps 2-4, add-on Step 5)
β1/β2 antagonist, reduces the production of aqueous humourOpen angle glaucoma
Block of NMDA channelDissociative anesthesia
Humanized monoclonal antibody against VEGF, intended to block blood vessel formation behind the retinaWet age-related macular degeneration
µ/δ/κ receptor competitive antagonist, blocks all effects of endogenous opioids and narcoticsNarcotic overdose
Inhibition of low threshold calcium current, intended to prevent burst discharge of thalamic relay neuronsPrevention of absence seizures
Rapidly-acting, short duration β2 agonist + muscarinic antagonist (longer bronchodilation than achievable with albuterol alone) Severe acute asthmatic attack (Steps 1-6), acute bronchoconstriction in COPD
Partial µ receptor agonist, intended to depress the cough reflexCough
Skeletal muscle nicotinic receptor agonist, relax skeletal muscles during surgery through depolarization blockDepolarizing neuromuscular blocking agent
Block of sodium channel, preferentially block firing in pain fibers (know why)Local anesthetics
Analogue of prostaglandin F2α, agonist for FP receptor, increases outflow of aqueous humour through the uveoscleral routeOpen angle glaucoma
H1/muscarinic antagonist Allergy, insomnia, motion sickness, symptoms of upper respiratory infection
Bind γ regulatory subunit of voltage-gated calcium channels, others?Prevention of generalized tonic-clonic and partial seizures
Partial µ receptor agonist, inhibits NE/5-HT transportMild pain
Muscarinic antagonist, intended to produce brief mydriasisPreparing the eye for examination
Inhaled glucocorticoid + rapidly-acting, long duration β2 agonistAsthma prophylaxis (Steps 3-6), prophylaxis for COPD that includes chronic bronchitis
Indirect perturbation of ion channel functionGeneral inhalation anesthetics

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