Exam 10 Drugs

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Can you name the Exam 10 Drugs?

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MechanismDrugDisease or Use
Non-absorbable saltsBowel prep
Inhibitors of urate reabsorption in the kidneyChronic gout
Viscous gel at acidic pH, intended to protect the mucosa from gastric acid and pepsin by creating a physical barrierPeptic ulcer disease
Reversible, non-selective inhibitors of cyclooxygenasesPain, inflammation, osteoarthritis, acute gout attack
SERM, same actions as estrogenPrevention of osteoporosis
Neutralize stomach acidPeptic ulcer disease (acute symptoms), gastroesophageal reflux disease (acute symptoms)
Fully human monoclonal antibody against RANKL (the primary signal to promote maturation of pre-osteoclasts to osteoclasts)Prevention and treatment of osteoporosis, bone metastases, drug-induced bone loss
Kill Helicobacter pylori (Quadruple/backup therapy. Name a drug other than a PPI)Peptic ulcer disease, MALT lymphoma
Kill H. pylori and other bacteria, inhibit prostaglandin-mediated inflammation and intestinal hypermotility, inhibit intestinal secretionPeptic ulcer disease, mild diarrhea
H1 receptor + muscarinic receptor antagonists, intended to reduce influence of the vestibular system on the chemoreceptor trigger zoneMotion sickness
NK1 receptor antagonist, intended to block substance P activation of the vagus nerve and chemoreceptor trigger zoneNausea and vomiting associated with cancer chemotherapy/radiation, postoperative nausea and vomiting
Kill Helicobacter pylori (First line therapy. Name a drug other than a PPI)Peptic ulcer disease, MALT lymphoma
Binds bile salts and some bacterial toxinsDiarrhea caused by excessive bile salts and some bacteria
Osteoporosis treatmentOsteoporosis
Reversible, non-selective inhibitors of cyclooxygenasesPain, fever, inflammation, osteoarthritis, acute gout attack
ClC-2 channel activator, intended to increase chloride secretion into the intestinal lumenChronic constipation
H2 receptor antagonists, remove histamine control of gastric acid secretionPeptic ulcer disease, gastroesophageal reflux disease
Fully human monoclonal antibody against TNF-αRheumatoid arthritis, inflammatory bowel disease resistant to infliximab
Reversible, somewhat COX-2 selective inhibitorPain, inflammation, osteoarthritis
Calcineurin inhibitor, immunosuppressantRefractory rheumatoid arthritis
Glucocorticoid receptor agonist (several mechanisms)Nausea and vomiting associated with cancer chemotherapy/radiation, postoperative nausea and vomiting
Immunoglobulin fusion protein that binds to antigen-presenting cells and blocks costimulatory signals required for T-cell activationRefractory rheumatoid arthritis
Purine synthesis inhibitor, immunosuppressantInflammatory bowel disease, refractory rheumatoid arthrtis
Humanized chimeric monoclonal antibody against TNF-αInflammatory bowel disease, rheumatoid arthritis
Inhibits microtubule assembly, intended to block replication of inflammatory cellsAcute gout attack
Irreversible, non-selective inhibitor of cyclooxygenasesPain, fever, inflammation
Anti-inflammatory glucocorticoid receptor agonists, immunosuppressantsInflammatory bowel disease (acute flareups), osteoarthritis, acute gout attack, rheumatoid arthritis
Pyrimidine synthesis inhibitorRheumatoid arthritis
MechanismDrugDisease or Use
PGE2 receptor agonist (PGE1 analog), intended to replace prostaglandin eliminated by NSAID useNSAID-induced peptic ulcer disease
5-HT3 receptor antagonist, intended to block serotonin activation of the vagus nerve and the chemoreceptor trigger zoneNausea and vomiting associated with cancer chemotherapy/radiation, postoperative nausea and vomiting
Parathyroid hormone agonist, stimulation of osteoblast action more than osteoclast action (with intermittent injection), increases GI calcium absorption, increases renal tubular caSevere osteoporosis
Promote peristalsisConstipation
Non-absorbable sugarsConstipation
Pyrophosphate analogs, inhibition of osteoclast action, induce osteoclast apoptosisPrevention and treatment of osteoporosis, malignancy-associated hypercalcemia, bone metastases, Paget’s disease
Hygroscopic indigestible fiber (absorb water in intestinal lumen or draw water into the intestinal lumen, increase bulk- can either liquefy or soldify stool)Diarrhea, constipation
Reversible, non-selective inhibitor of cyclooxygenase, inhibitor of urate reabsorption in the kidneyAcute gout attack
Softener of formed stools by attracting fat and water to the stool (essentially “grease”)Constipation, to avoid straining after MI or surgery
Weak µ receptor agonistsOsteoarthritis
Inhibitor of cyclooxygenase and 5-lipoxygenase in GI tract, modulator of B-cell responses and angiogenesis (sulfasalazine metabolized to mesalamine by colon bacteria)Inflammatory bowel disease, rheumatoid arthritis
Non-absorbable saltConstipation
TNF-α receptor fused to Fc regionRheumatoid arthritis
Muscarinic receptor antagonist, intended to reduce influence of the vestibular system on the chemoreceptor trigger zoneMotion sickness
Reversible, relatively-selective COX-2 inhibitorPain, inflammation, osteoarthritis
D2 receptor antagonists (metoclopramide also a muscarinic receptor agonist), intended to block dopamine activation of the chemoreceptor trigger zone and vomiting centerPostoperative nausea and vomiting
Reduced breakdown of proteoglycans, protease inhibition, inhibition of prostaglandin synthesisOsteoarthritis (increase joint lubrication, relieve pain)
Kill Helicobacter pylori (First line therapy for penicillin allergy. Name the drug substituted for amoxicillin)Peptic ulcer disease, MALT lymphoma
Inhibitor of dihydrofolate reductase, inducer of adenosine releaseRheumatoid arthritis
Peripheral µ receptor agonist (slows GI motility)Traveler’s diarrhea, diarrhea associated with inflammatory bowel disease and irritable bowel syndrome, diarrhea associated with cancer chemotherapy/radiation
Recombinant IL-1 receptor antagonistRheumatoid arthritis
Inhibition of osteoclast action, induces osteoclast apoptosisPrevention of osteoporosis
Weak, reversible, non-selective inhibitor of cyclooxygenases mainly in CNSPain, fever, osteoarthritis
Modulator of cytokine secretion, inhibitor of lysosomal enzyme release, inhibitor of macrophage functionEarly or mild rheumatoid arthritis
Inhibitors of xanthine oxidase, intended to reduce uric acid synthesisChronic gout
Irreversible proton pump (H+/K+-ATPase) inhibitors, block secretion of gastric acidPeptic ulcer disease of all etiologies, Zollinger-Ellison syndrome, gastroesophageal reflux disease
Synthetic calcitonin analog, inhibition of osteoclast actionPaget’s disease, prevention and treatment of osteoporosis, malignancy-associated hypercalcemia, vertebral fracture

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