| Description | Species |
| Reputation for being tenacious and doing anything to get what they want; hail from planet Earth | |
| They AI that developed sentience and exiled the above species | |
| Giant worms that Commander Shepard can destroy with ease in a Mako | |
| They studied Earth from Mars during Cro-Magnon times | |
| 'We have no beginning and no end. Our victory is inevitable. ' | |
| Hive mind--you have the choice of destroying the 'Last of Its Kind' | |
| Quadrupedal, violent, unintelligent creatures used for meat on planets like Feros | |
| Plans were made to destroy them and replace them with the Geth as regulators of the Citadel | |
| Commander Shepard has the option of calling them 'Big, Stupid, Jellyfish!' | |
| When placed on a Dragon's Tooth, other species' innards decay and are replaced, becoming zombie-like these | |
| | Description | Species |
| Citadel Council species; blue skin, one gender | |
| They have been exiled from their own planet by AI they designed | |
| An enormous plant that spawns 'Creepers' from itself | |
| They speak in monotone, so must state their emotion before talking | |
| Citadel Coucil species; many are scientists or researchers because of theri quick thinking and analyzing minds | |
| Hit by a genophage that raised their infant mortality rate | |
| Never met in Mass Effect, but known to be unfriendly to the Alliance | |
| They live in highly pressurized suits that mach their home environment; they are short and stubby | |
| Citadel Council species; almost bird-like in appearance | |
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