| Died from... | Character | Episode Title |
| Impaled by Anna | |
| Exploded by Lucifer | |
| Mauled by hell hounds | |
| Burned to death on the ceiling of Sam's nursery | |
| Stabbed to Death | |
| Killed in Explosion of the Roadhouse | |
| Dies in an explosion | |
| Shot by hunters | |
| Shot by the owner of the 'Mystery Spot' | |
| Neck snapped by Lucifer | |
| Incinerated by Michael | |
| Shot by hunters | |
| Died from food poisoning | |
| Killed with Sam's demonic powers | |
| Fell in the shower | |
| Impaled by Sam | |
| Jumped into the pits of hell | |
| Exorcised by Dean | |
| Stabbed by Anna | |
| Killed with Sam's demonic powers | |
| Sold soul to Azazel | |
| Chokes to death | |
| Shot by Dean | |
| | Died from... | Character | Episode Title |
| Decapitated by Sam | |
| Inadvertently axed by Sam | |
| Mauled by a dog | |
| Burned to death on her and Sam's bedroom ceiling | |
| Obliterated by Archangels | |
| Mauled by hellhounds | |
| Impaled by Dean | |
| Neck snapped by Azazel | |
| Shot by Sam | |
| Killed in a car accident | |
| Pulled into hell by Sam | |
| Crushed by a falling desk | |
| 'Sent away' by Lilith | |
| Obliterated by Lilith | |
| Run over by a car | |
| Neck snapped by Lucifer | |
| Electrocuted | |
| Killed by a demon under Ava's controls | |
| Neck snapped by Jake | |
| Stabbed by Dean | |
| Shot by a mugger | |
| Stabbed by a demon | |
|