Immunosuppressant Drugs

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Can you name the Immunosuppressant Drugs?

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MechanismDrug (Generic)Clinical Uses
metabolized into a fraudulent nucleotide, causing chain terminationprevention of organ transplant rejection, rheumatoid arthritis, inflammatory bowel disease
binds to FKBP-12, inhibiting activity of mTOR (does NOT affect calcineurin activity), thus inhibiting cell cycle progression from G1 to S phaseprevention of organ transplant rejections in combination therapy with a calcineurin inhibitor and glucocorticoids or with mycophenolate mofetil and glucocorticoids
alkylating agent; transfers alkyl group to protein, DNA, RNA, etcorgan rejection after transplantation (blocks acute rejection)
binding activates complement and cell-mediated cytotoxicity, block lymphocyte functioninduction of immunosuppression, treatment of acute renal transplant rejection
Human monoclonal antibody that recognizes cytokine B Lymphocyte stimulator (BLYS)Systemic Lupus Erythematous
chimeric human-mouse Ab, recognizes the alpha subunit of IL-2 receptor (CD25); prevents IL-2 mediated T-cell activation and proliferation, depletion of activated T-cellsprevent acute organ rejection
humanized Ab that recognizes CD52 present on T- and B-cells; binds to CD52 on normal and malignant T- and B-cells, killing them by Ab-dependant lysisB-cell chronic lymphocytic leukemia
binds Rho antigens, prevents sensitization of Rh-negative women to an Rh-positive fetustreat Rh incompatibility and prevent hemolytic disease of the newborn
binds to FKBP, inhibititing calcineurin required for dephosphorylation of NF-ATc, thus inhibiting T-cell activationorgan transplantation, GVHD, autoimmune disorders
folic acid antagonist that inhibits dihydrofolate reductase, thus inhibiting DNA, RNA, and protein synthesisinflammatory bowel disease, rheumatoid arthritis, GVHD
MechanismDrug (Generic)Clinical Uses
recognizes human CD3 molecule on T-cells, inactivating T-cell functiontreatment of acute allograft rejection and steroid-resistant rejection
chimeric human-mouse Ab that recognizes CD20 (pan B-cell prot)
chimeric human-mouse AB that recognizes TNFα; blocks TNFα from binding receptor, leading to suppression of inflammatory cytokines (IL-1, IL-6) and adhesion moleculesrheumatoid arthritis, Crohn's disease
interferes with cell cycle of activated lymphoid cells, inhibits produciton of inflammatory mediatorsfirst-line immunosuppressive therapy for transplants; organ rejection or GVHD, rheumatoid arthritis, inflammatory bowel disease
inhibits calcineurin required for dephosphorylation of NF-ATc, thus inhibiting T-cell activationorgan transplantation, GVHD, autoimmune disorders
fusion protein of human IgG constant regions fused to TNF receptor, binds to TNFα and TNFβ; blocks TNF from binding receptor, leading to suppression of inflammatory cytokines andrheumatoid arthritis
fusion protein of human IgG Fc region and the CD2 binding portion of LFA-3; inhibits T-cell activation by binding to CD2Plaque psoriasis
human Ab that recognizes TNFα; blocks TNFα from binding receptor, leading to suppression of inflammatory cytokines and adhesion moleculesrheumatoid arthritis
inhibits purine synthesisprevention of transplant rejection in combination with glucocorticoids and calcineurin inhibitior

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