Movement Disorders Drugs

Random Miscellaneous Quiz

Can you name the Movement Disorders Drugs?

Quiz not verified by Sporcle

embed
 plays        
How to Play
HintAnswer
MOA: Dopamine precursor able to cross the BBB where it is decarboxylated by dopa decarboxylase to form dopamine.
Olanzapine class
P-kinetics: Note: Antidepressant MAOIs are either nonspecific or inhibit MAO-A more specifically (5-HT & NE)
Use: Most effective drug in tx of Tourette's
SE: HA, nasal congestion, increased arousal, pulmonary infiltrates, ergoline-induced s/s, erythromelagia, vasospasm, & pleural or retroperitoneal fibroses.
Use: Reduced response to fluctuations w/ L-dopa. Decreased L-dopa clearance. Decreased dopa decarboxylase --> compensatory increase in COMT.
P-kinetics: SQ. Rapid onset ~ 10 min. Duration 2 hrs
MOA: D1 and D2 receptor agonist
Use: depression associated with Huntington's disease
P-kinetics: Similar to Pramipexole
SE: GI (L-dopa alone): anorexia, n/v (avoid anti-emetics like phenothiazines d/t their extrapyramidal effects -- dopamine antagonist; carbidopa reduces these effects.
SE: May be hepatotoxic - (needs signed pt consent & liver monitoring Q 2 wks x 1 yr)
SE: Mental Disturbances: confusion, hallucinations, delusions, other psychiatric reactions.
Use: prolong ALS survival by months
SSRI class
SE: Ergoline-induced toxicity effects unlikely. Postural hypotension, fatigue, somnolence, peripheral edema, nausea, constipation, dyskinesias, & confusion.
Amantadine class
Tetrabenxine class
Levodopa class
MOA: Preferential affinity for D3 family of receptors
Apomorphine class
SE: May interfere with uptake - Rx metabolizes L-dopa into 3-methyldopa which competes for active transport across the BBB.
SE: Increased L-dopa toxicity (dyskinesias, nausea, & confusion), diarrhea, abd pain, orthostatic hypotension, sleep disturbances, & orange urine.
MOA: Prevents the metabolism of L-dopa --> 3-O-methyldopa (3OMD) by Catechol-0-methyltransferase
SE: CV: Increased HR, PVCs, A fib (rare), postural hypotension, HTN (usually in the presence of non-specific MAOI or with large doses).
Rasagiline class
Use: Similar to Pramipexole
SE: Asthenia, dizziness, GI disorders, & elevation of liver enzymes.
SE: If adverse effects become too severe withdraw gradually. break for 3-21 days, and reinstate gradually
Haloperidol class
Selegiline class
P-kinetics: Start at low dose & gradually increase
HintAnswer
MOA: D2 receptor agonist (partial D1 agonist)
SE: GI: anorexia, n/v, constipation, dyspepsia, peptic ulcers, symptoms of reflux esophagitis. CV: postural hypotension & cardiac arrhythmias. Dyskinesias.
Use: Can be used as 1st line tx for Parkinson's dz - often in combo w/ Sinemet. Commonly used to tx hyperprolactinemia.
Quetiapine class
P-kinetics: Start with a small dose
Pramipexole class
MOA: Somewhat selective MAO-B inhibitors. Retard the breakdown of dopamine
Use: May improve tremor & rigidity in Parkinsons. Little effect on bradykinesia.
Interactions: Should not be taken w/ meperidine, TCAs, serotonin reuptake inhibitors, or in combo w/ nonspecific MAOIs
Ropinirole class
Pergolide class
Interactions: Vitamin B6 enhances the extracerebral metabolism of L-dopa. MAOI w/ L-dopa can --> HTNive crisis if given within 2 weeks of each other.
Use: Similar to Bromocriptine, but more effective. May benefit pts not receiving L-dopa. Aids pt w/ response fluctuations to L-dopa
MOA: Pure D2 receptor agonist
Carbidopa class
MOA: Inhibits the L-dopa --> dopamine conversion by dopa decarboxylase in the periphery (does not cross BBB).
Clonazepam class
TCA class
Contraindications: psychotic illness, MI hx, PVD, peptic ulcers
MOA: Central (brain) anti-cholinergic
Procyclidine class
P-kinetics: Only 1-3% enters the brain across BBB unaltered. Peak plasma levels 1-2 hrs post PO dose. Plasma t1/2 = 1-2 hrs (pts vary -- dosing 3-4x/day).
Butyrophenones class
Use: Monotherapy for mild Parkinsonism or combo tx for advanced pts. Reduces L-dopa dose & smooths response fluctuations. Putative neuroprotective effects (scavenges free radicals)
Benzotropine class
Carbidopa + levidopa (1:10 or 1:4)
P-kinetics: Readily absorbed from intestines (depends on rate of gastric emptying and pH -- delayed by food). Some other AAs can compete for transport across the BBB.
Tolcapone class
MOA: Increases dopamine release & reduces dopamine reuptake into dopaminergic nerve terminals of substantia nigra neurons. Unknown MOA.
Contraindications: Prostatic hyperplasia, obstructive GI dz, & angle-closure glaucoma
SE: CNS: drowsiness, mental slowness, inattention, restless, confusion, agitation, delusions, hallucinations, & mood changes.
Fluphenzaine class
HintAnswer
SE: Other: dry mouth, blurred vision, mydriasis, urinary retention, n/v, constipation, tachycardia, increased IOP.
Carbamazepine class
SE: Nausea (pretreat w/ anti-emetic - trimethobenzamide or domiperidone), dyskinesias, drowsiness, sweating, hypotension
MOA: Not completely known. Inhib effects on glutamate-R, NMDA antag, Inactivation of voltage gated Na+ channels. Interferes w/ intracellular events post excitatory AA-R activation
Use: Huntington's dz pts w/ psychosis or disruptive behavior. Also helpful w/ chorea
P-kinetics: Only helpful for Huntington's dz chorea at very high doses
Trihexyphenidyl class
P-kinetics: Given PO. Loses effectiveness over time.
Use: Increases amount of L-dopa able to cross the BBB. Combo with L-dopa allows for L-dopa dose reduction up to 85%.
P-kinetics: Well absorbed orally. T1/2 ~ 12 hrs. Hepatic metabolism (cytochrome P450, CYP1A2) -- caution in pts w/ hepatic insufficiency.
Group P-kinetics: Advantages: No enzymatic conversion required, crosses BBB w/o competing for amino acid transporter. No potentially toxic metabolites
P-kinetics: Response can decline over time or stop completely. Start at small dose & escalate as effects diminish. Wearing off rxs. Toxicity concern is supersensitivity develpmnt -
Entacapone class
Use: alleviation of chorea
Biperiden class
Contraindications: psychotic pts, angle closure glaucoma (Increased IOP), active peptic ulcers, hx of melanoma (melanin precursor)
Phenothiazine class
SE: Dyskinesias: chorea, ballismus, athetosis, dystonia, myoclonus, tics, tremors. Behavioral effects: anxiety/ agitation, insomnia/ somnolence, confusion/ delusions/ hallucination
P-kinetics: Variable absorption from GI, peak plasma levels 1-2 hrs post PO dose. Excreted in bile & feces. Build up dose slowly over 2-3 mo to avoid adverse effects
P-kinetics: Rapid PO absorption, excreted unchanged in urine, gradually increase dose
Bromocriptine class
Use: Enhance & prolong the effects of L-dopa; reduce response fluctuations; lowers necessary dose of L-dopa. ?Antioxidant properties?
Reserpine class
Orphenadrine class
Use: Gold standard in Parkinson's dz - most efficacious treatment
SE: Insomnia when taken late in the day
Risperidone class
Use: alleviation of chorea if refractory to atypical
P-kinetics: 2/3 appears in urine as metabolites within 8 hrs (homovanillic acid - HVA and dihydrocyphenylacetic acid - DOPAC). Best response is in the first few yrs of tx.
Clonidine class
Use: Temporary relief of off-period akinesia in Parkinsons. Also used to tx ED.
Riluzole class

Friend Scores


  Player Best Score Plays Last Played
You You haven't played this game yet.

You Might Also Like...

Extras

Created Oct 8, 2011ReportNominate
Tags:disorder, drug, movement