Local Anesthetics

Random Miscellaneous or Nintendo Quiz

Can you name the Local Anesthetics?

Quiz not verified by Sporcle

 plays        
How to Play
HintAnswer
Nerve selectivity: large diameter, slow firing, myelinated 'A' type motor neuron fibers
Procaine class
Medium duration ester
Prilocaine class
Mepivacaine class
Surface active ester
SE cont: All are vasodilators (except cocaine). Heart block, arrythmias, low BP. Can form metabolites that create hypersensitivity reactions.
Class P-kinetics cont: Most bound by plasma PRO, which effects clinical effects and toxicity.
SE: similar to tetracaine. However more cardiotoxic (arrythmias and hypotension), may be irreversible. Tx with epi, atropine, and bretylium.
Short duration ester
Class P-kinetics: systemic absorption is proportional to vascularization, widely distributed in not locally injected.
Long duration amide
Benzocaine class
SE: similar to tetracaine
Cocaine class
HintAnswer
Tetracaine class
Long duration ester
SE: light headedness, sedation, restless, nystagmus, tonic-clonic convulsions (tx with sedative hypnotics). Resp and CV collapse. High [ ] may permanent damage nerves.
Lidocaine class
MOA: State dependent blockage of voltage dependent Na channels, prevent depolarization and conduction of APs in excitable cells esp. neurons when localized next to neurons
Medium duration amide
Class of P-kinetics cont: pH dependent (HH principles) ionization important. Hydrolyzed relatively rapidly via butyrylcholinesterase (except benzocaine which is topical only)
Class P-kinetics cont: Weak base which must be lipophilic to pass through cell membrane to internally block channels and hydrophilic to bind channel.
Ropivacaine class
Nerve selectivity: rapid firing, small diameter 'C' fibers and medium diameter, myelinated B sympathetic preganglionic fibers.
Class P-kinetics: Similar in absorption & distribution and ionization to esters. Metabolism via CYP in liver (longer duration), liver function important in metabolism.
SE: metabolized to products which can cause methemoglobinemia (treat with methylene blue)
Etidocaine class
SE: Can also block NE --> vasoconstriction and CV toxicity (HTN, cerebral hemorrhage, arrhythmias, and MI's)
Bupivacaine class

Friend Scores


  Player Best Score Plays Last Played
You You haven't played this game yet.

You Might Also Like...

Extras

Created Sep 18, 2011ReportNominate
Tags:Nintendo, local