Local Anesthetics

Random Miscellaneous or Nintendo Quiz

Can you name the Local Anesthetics?

Quiz not verified by Sporcle

 plays        
How to Play
HintAnswer
Class P-kinetics: systemic absorption is proportional to vascularization, widely distributed in not locally injected.
Surface active ester
Medium duration amide
Lidocaine class
SE: similar to tetracaine
Nerve selectivity: large diameter, slow firing, myelinated 'A' type motor neuron fibers
Class of P-kinetics cont: pH dependent (HH principles) ionization important. Hydrolyzed relatively rapidly via butyrylcholinesterase (except benzocaine which is topical only)
Class P-kinetics: Similar in absorption & distribution and ionization to esters. Metabolism via CYP in liver (longer duration), liver function important in metabolism.
Nerve selectivity: rapid firing, small diameter 'C' fibers and medium diameter, myelinated B sympathetic preganglionic fibers.
Tetracaine class
Long duration amide
Benzocaine class
Cocaine class
Prilocaine class
Class P-kinetics cont: Most bound by plasma PRO, which effects clinical effects and toxicity.
HintAnswer
Bupivacaine class
SE: metabolized to products which can cause methemoglobinemia (treat with methylene blue)
Procaine class
Medium duration ester
SE: light headedness, sedation, restless, nystagmus, tonic-clonic convulsions (tx with sedative hypnotics). Resp and CV collapse. High [ ] may permanent damage nerves.
SE: Can also block NE --> vasoconstriction and CV toxicity (HTN, cerebral hemorrhage, arrhythmias, and MI's)
SE cont: All are vasodilators (except cocaine). Heart block, arrythmias, low BP. Can form metabolites that create hypersensitivity reactions.
Etidocaine class
Ropivacaine class
MOA: State dependent blockage of voltage dependent Na channels, prevent depolarization and conduction of APs in excitable cells esp. neurons when localized next to neurons
Class P-kinetics cont: Weak base which must be lipophilic to pass through cell membrane to internally block channels and hydrophilic to bind channel.
SE: similar to tetracaine. However more cardiotoxic (arrythmias and hypotension), may be irreversible. Tx with epi, atropine, and bretylium.
Short duration ester
Long duration ester
Mepivacaine class

Friend Scores


  Player Best Score Plays Last Played
You You haven't played this game yet.

You Might Also Like...

Extras

Created Sep 18, 2011ReportNominate
Tags:Nintendo, local