Local Anesthetics

Random Miscellaneous or Nintendo Quiz

Can you name the Local Anesthetics?

Quiz not verified by Sporcle

How to Play
Score 0/30 Timer 20:00
HintAnswer
SE: similar to tetracaine
Class of P-kinetics cont: pH dependent (HH principles) ionization important. Hydrolyzed relatively rapidly via butyrylcholinesterase (except benzocaine which is topical only)
Long duration ester
Class P-kinetics: Similar in absorption & distribution and ionization to esters. Metabolism via CYP in liver (longer duration), liver function important in metabolism.
Short duration ester
Class P-kinetics cont: Weak base which must be lipophilic to pass through cell membrane to internally block channels and hydrophilic to bind channel.
Benzocaine class
SE: light headedness, sedation, restless, nystagmus, tonic-clonic convulsions (tx with sedative hypnotics). Resp and CV collapse. High [ ] may permanent damage nerves.
SE: metabolized to products which can cause methemoglobinemia (treat with methylene blue)
Prilocaine class
Cocaine class
Procaine class
SE: similar to tetracaine. However more cardiotoxic (arrythmias and hypotension), may be irreversible. Tx with epi, atropine, and bretylium.
SE cont: All are vasodilators (except cocaine). Heart block, arrythmias, low BP. Can form metabolites that create hypersensitivity reactions.
Medium duration amide
HintAnswer
Nerve selectivity: rapid firing, small diameter 'C' fibers and medium diameter, myelinated B sympathetic preganglionic fibers.
Medium duration ester
Tetracaine class
Class P-kinetics: systemic absorption is proportional to vascularization, widely distributed in not locally injected.
MOA: State dependent blockage of voltage dependent Na channels, prevent depolarization and conduction of APs in excitable cells esp. neurons when localized next to neurons
Etidocaine class
Long duration amide
Bupivacaine class
Lidocaine class
Nerve selectivity: large diameter, slow firing, myelinated 'A' type motor neuron fibers
Ropivacaine class
Mepivacaine class
Class P-kinetics cont: Most bound by plasma PRO, which effects clinical effects and toxicity.
Surface active ester
SE: Can also block NE --> vasoconstriction and CV toxicity (HTN, cerebral hemorrhage, arrhythmias, and MI's)

Friend Scores


  Player Best Score Plays Last Played
You You haven't played this game yet.

You Might Also Like...

Extras

Created Sep 18, 2011ReportNominate
Tags:Nintendo, local