Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
Inhibits NPC1L1 transport in the gut
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Must monitor creatine kinase
Take this drug to decrease flushing with Niacin
Atorvastatin
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Simvastatin
Colestipol
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Cholestyramine
Anion exchange resin prevents bile acid binding
Fluvastatin
Contraindicated in kidney, liver, and biliary dz
Ezetimibe
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
Contraindicated in pregnancy and liver dz
Decreases LDL and TG
QuestionAnswer
Downregulates apo CIII
Decreases VLDL and TG, increases LPL activity
Decreases VLDL, LDL, Lp(a) and increases HDL
Gemfibrozil
Competitively inhibits HMG-CoA reductase
Single agent to treat familial dysbetalipidemia
Decreases CRP
Pravastatin
Colesevelam
Decreases FFA to liver
Fenofibrate
Lovastatin
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Decreases LDL
Rosuvastatin
Synergistic with statins
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Upregulates LPL, apo AI, AII
Niacin/Nicotinic acid/Vit B3

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Created Mar 14, 2011ReportNominate
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