Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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Decreases FFA to liver
Fenofibrate
Contraindicated in pregnancy and liver dz
Single agent to treat familial dysbetalipidemia
Cholestyramine
Synergistic with statins
Must monitor creatine kinase
Lovastatin
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Ezetimibe
Inhibits NPC1L1 transport in the gut
Pravastatin
Upregulates LPL, apo AI, AII
Atorvastatin
Decreases CRP
Decreases VLDL and TG, increases LPL activity
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Gemfibrozil
Contraindicated in kidney, liver, and biliary dz
QuestionAnswer
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
Downregulates apo CIII
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Decreases LDL
Decreases VLDL, LDL, Lp(a) and increases HDL
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Rosuvastatin
Take this drug to decrease flushing with Niacin
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
Competitively inhibits HMG-CoA reductase
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Colestipol
Niacin/Nicotinic acid/Vit B3
Decreases LDL and TG
Anion exchange resin prevents bile acid binding
Simvastatin
Fluvastatin
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Colesevelam

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Created Mar 14, 2011ReportNominate
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