Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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Decreases LDL
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Niacin/Nicotinic acid/Vit B3
Colesevelam
Upregulates LPL, apo AI, AII
Decreases LDL and TG
Must monitor creatine kinase
Decreases FFA to liver
Synergistic with statins
Cholestyramine
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Inhibits NPC1L1 transport in the gut
Take this drug to decrease flushing with Niacin
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Competitively inhibits HMG-CoA reductase
Fenofibrate
Decreases VLDL and TG, increases LPL activity
Pravastatin
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
QuestionAnswer
Gemfibrozil
Ezetimibe
Contraindicated in kidney, liver, and biliary dz
Decreases VLDL, LDL, Lp(a) and increases HDL
Decreases CRP
Colestipol
Simvastatin
Downregulates apo CIII
Lovastatin
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Contraindicated in pregnancy and liver dz
Fluvastatin
Atorvastatin
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Rosuvastatin
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
Anion exchange resin prevents bile acid binding
Single agent to treat familial dysbetalipidemia

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Created Mar 14, 2011ReportNominate
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