Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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Downregulates apo CIII
Single agent to treat familial dysbetalipidemia
Decreases LDL
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Upregulates LPL, apo AI, AII
Ezetimibe
Atorvastatin
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Simvastatin
Niacin/Nicotinic acid/Vit B3
Decreases VLDL, LDL, Lp(a) and increases HDL
Anion exchange resin prevents bile acid binding
Contraindicated in kidney, liver, and biliary dz
Inhibits NPC1L1 transport in the gut
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Must monitor creatine kinase
Pravastatin
Competitively inhibits HMG-CoA reductase
QuestionAnswer
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Decreases CRP
Decreases LDL and TG
Synergistic with statins
Gemfibrozil
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Fenofibrate
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Lovastatin
Colesevelam
Contraindicated in pregnancy and liver dz
Decreases FFA to liver
Rosuvastatin
Colestipol
Cholestyramine
Fluvastatin
Take this drug to decrease flushing with Niacin
Decreases VLDL and TG, increases LPL activity

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Created Mar 14, 2011ReportNominate
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