Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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QuestionAnswer
Simvastatin
Rosuvastatin
Upregulates LPL, apo AI, AII
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Decreases VLDL, LDL, Lp(a) and increases HDL
Lovastatin
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Must monitor creatine kinase
Anion exchange resin prevents bile acid binding
Contraindicated in kidney, liver, and biliary dz
Decreases CRP
Single agent to treat familial dysbetalipidemia
Fluvastatin
Synergistic with statins
Ezetimibe
Colestipol
Atorvastatin
Contraindicated in pregnancy and liver dz
QuestionAnswer
Pravastatin
Take this drug to decrease flushing with Niacin
Cholestyramine
Fenofibrate
Decreases LDL and TG
Decreases FFA to liver
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Competitively inhibits HMG-CoA reductase
Decreases LDL
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Downregulates apo CIII
Inhibits NPC1L1 transport in the gut
Niacin/Nicotinic acid/Vit B3
Decreases VLDL and TG, increases LPL activity
Colesevelam
Gemfibrozil
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants

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