Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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QuestionAnswer
Fenofibrate
Niacin/Nicotinic acid/Vit B3
Competitively inhibits HMG-CoA reductase
Decreases VLDL, LDL, Lp(a) and increases HDL
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Colestipol
Simvastatin
Rosuvastatin
Take this drug to decrease flushing with Niacin
Downregulates apo CIII
Single agent to treat familial dysbetalipidemia
Ezetimibe
Decreases VLDL and TG, increases LPL activity
Gemfibrozil
Inhibits NPC1L1 transport in the gut
Lovastatin
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Contraindicated in kidney, liver, and biliary dz
Decreases LDL and TG
QuestionAnswer
Decreases FFA to liver
Atorvastatin
Colesevelam
Cholestyramine
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
Anion exchange resin prevents bile acid binding
Decreases CRP
Upregulates LPL, apo AI, AII
Decreases LDL
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
Synergistic with statins
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Contraindicated in pregnancy and liver dz
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Fluvastatin
Must monitor creatine kinase
Pravastatin

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Created Mar 14, 2011ReportNominate
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