Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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Colesevelam
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
Contraindicated in pregnancy and liver dz
Simvastatin
Pravastatin
Ezetimibe
Contraindicated in kidney, liver, and biliary dz
Rosuvastatin
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Colestipol
Lovastatin
Cholestyramine
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Must monitor creatine kinase
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Decreases VLDL and TG, increases LPL activity
Decreases LDL
QuestionAnswer
Single agent to treat familial dysbetalipidemia
Anion exchange resin prevents bile acid binding
Fenofibrate
Decreases CRP
Decreases FFA to liver
Synergistic with statins
Upregulates LPL, apo AI, AII
Competitively inhibits HMG-CoA reductase
Inhibits NPC1L1 transport in the gut
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Atorvastatin
Decreases VLDL, LDL, Lp(a) and increases HDL
Gemfibrozil
Fluvastatin
Niacin/Nicotinic acid/Vit B3
Take this drug to decrease flushing with Niacin
Decreases LDL and TG
Downregulates apo CIII

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Created Mar 14, 2011ReportNominate
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