Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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Downregulates apo CIII
Fenofibrate
Anion exchange resin prevents bile acid binding
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
Competitively inhibits HMG-CoA reductase
Gemfibrozil
Lovastatin
Must monitor creatine kinase
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Atorvastatin
Decreases LDL and TG
Niacin/Nicotinic acid/Vit B3
Take this drug to decrease flushing with Niacin
Decreases FFA to liver
Decreases VLDL, LDL, Lp(a) and increases HDL
Colesevelam
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
QuestionAnswer
Single agent to treat familial dysbetalipidemia
Upregulates LPL, apo AI, AII
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
Cholestyramine
Colestipol
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Decreases LDL
Rosuvastatin
Pravastatin
Ezetimibe
Synergistic with statins
Inhibits NPC1L1 transport in the gut
Contraindicated in pregnancy and liver dz
Simvastatin
Fluvastatin
Contraindicated in kidney, liver, and biliary dz
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Decreases CRP
Decreases VLDL and TG, increases LPL activity

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Created Mar 14, 2011ReportNominate
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