Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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QuestionAnswer
Contraindicated in pregnancy and liver dz
Decreases LDL and TG
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
Upregulates LPL, apo AI, AII
Synergistic with statins
Niacin/Nicotinic acid/Vit B3
Rosuvastatin
Decreases CRP
Colestipol
Take this drug to decrease flushing with Niacin
Contraindicated in kidney, liver, and biliary dz
Single agent to treat familial dysbetalipidemia
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Decreases LDL
Colesevelam
Decreases VLDL and TG, increases LPL activity
Simvastatin
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Atorvastatin
QuestionAnswer
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Fluvastatin
Cholestyramine
Inhibits NPC1L1 transport in the gut
Must monitor creatine kinase
Lovastatin
Competitively inhibits HMG-CoA reductase
Pravastatin
Decreases VLDL, LDL, Lp(a) and increases HDL
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
Anion exchange resin prevents bile acid binding
Downregulates apo CIII
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Ezetimibe
Fenofibrate
Decreases FFA to liver
Gemfibrozil

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Created Mar 14, 2011ReportNominate
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