Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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Decreases LDL and TG
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Competitively inhibits HMG-CoA reductase
Fluvastatin
Pravastatin
Gemfibrozil
Single agent to treat familial dysbetalipidemia
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
Contraindicated in kidney, liver, and biliary dz
Rosuvastatin
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Decreases CRP
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Anion exchange resin prevents bile acid binding
Decreases FFA to liver
Upregulates LPL, apo AI, AII
Downregulates apo CIII
Niacin/Nicotinic acid/Vit B3
QuestionAnswer
Fenofibrate
Atorvastatin
Decreases VLDL and TG, increases LPL activity
Decreases LDL
Colestipol
Colesevelam
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Must monitor creatine kinase
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Lovastatin
Synergistic with statins
Take this drug to decrease flushing with Niacin
Inhibits NPC1L1 transport in the gut
Cholestyramine
Simvastatin
Ezetimibe
Decreases VLDL, LDL, Lp(a) and increases HDL
Contraindicated in pregnancy and liver dz

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Created Mar 14, 2011ReportNominate
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