Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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Decreases CRP
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Rosuvastatin
Simvastatin
Niacin/Nicotinic acid/Vit B3
Ezetimibe
Competitively inhibits HMG-CoA reductase
Colestipol
Decreases LDL and TG
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Cholestyramine
Pravastatin
Contraindicated in kidney, liver, and biliary dz
Downregulates apo CIII
Upregulates LPL, apo AI, AII
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Atorvastatin
Single agent to treat familial dysbetalipidemia
QuestionAnswer
Contraindicated in pregnancy and liver dz
Must monitor creatine kinase
Synergistic with statins
Take this drug to decrease flushing with Niacin
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Fenofibrate
Fluvastatin
Decreases VLDL and TG, increases LPL activity
Decreases LDL
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
Lovastatin
Anion exchange resin prevents bile acid binding
Colesevelam
Decreases VLDL, LDL, Lp(a) and increases HDL
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Gemfibrozil
Decreases FFA to liver
Inhibits NPC1L1 transport in the gut
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins

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Created Mar 14, 2011ReportNominate
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