Lipid Lowering Agents

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Can you name the Lipid Lowering Agents?

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Gemfibrozil
Cholestyramine
Drug interaction with digitalis, warfarin, statins, aspirin, ascorbic acis, iron AND a decrease in fat soluble vitamins
Anion exchange resin prevents bile acid binding
Contraindicated in kidney, liver, and biliary dz
Contraindicated in pregnancy and liver dz
Decreases VLDL and TG, increases LPL activity
Ezetimibe
Downregulates apo CIII
Must monitor creatine kinase
Simvastatin
Fenofibrate
Inhibits NPC1L1 transport in the gut
Competitively inhibits HMG-CoA reductase
Fluvastatin
Decreases VLDL, LDL, Lp(a) and increases HDL
Contraindicated in DM, peptic ulcers, chronic liver dz, gout
Colestipol
SE: Gallstones, elev liver enzymes, increased action of oral anticoagulants
QuestionAnswer
Lovastatin
Niacin/Nicotinic acid/Vit B3
Upregulates LPL, apo AI, AII
SE: flushing, itching, GI upset, hepatic dysfunction, hyperuricemia, tachyarrhythmias
Contraindicated in dysbetalipoproteinemia (TG>400) and relatively contraindicated in TG >200
Decreases LDL
Use 2 - 3 of these agents to treat familial combined hyperlipoproteinemia
Rosuvastatin
Colesevelam
Decreases LDL and TG
Take this drug to decrease flushing with Niacin
Atorvastatin
Single agent to treat hyperlipoproteinemia (type I) or familial hypertriglyceridemia (type IV)
Use 2-3 of these agents to treat defective apo-B or familial hypercholesterolemia (Type IIa)
Decreases CRP
Synergistic with statins
Single agent to treat familial dysbetalipidemia
Decreases FFA to liver
Pravastatin

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Created Mar 14, 2011ReportNominate
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