anti-viral agents

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Can you name the anti-viral agents?

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SE: GI symptoms and psychological effects
SE: bronchospasm and psychological effects
Agent(s) used in the chemoprophylaxis and treatment of influenza A (if administered early). Also can be used in the tx of Parkinson's dz
________ + peg IFN alpha-2A = standard tx for HCV
Use: For the prophylaxis and tx (if taken within 2 days of symptoms)
Agents used in RSV infections
RSV agent used only for prophylaxis
Oral bioavailability is increased with high fat meal and decreased with antacid
AVOID in asthma and COPD
Negative sense, single-stranded RNA virus
SE: hemolytic anemia, skin rash, depression, fatigue, irritability, nausea, insomnia
Neuroaminidase Inhibitors
Contraindicated in pts with uncorrected anemia, end-stage renal failure, ischemia vascular dz, and pregnancy
Used in children with severe RSV to minimize bronchiolitis or PNA.
M2 Inhibitors
Blocks ___ ion channels and INHIBITS UNCOATING
Most common cause of bronchiolitis and PNA in children < 1 y.o.
100% resistance with seasonal H3N2 and 2009 pandemic flu
Hospitalizes 2-3% of infants in the first 12 months of life
A humanized monoclonal Ab directed against an epitope in the A antigen site on the F fusion protein of RSV (blocks VIRAL ENTRY to host cells)
Active against Influenza A only
Adverse reactions: GI upset, CNS (dopaminergic effects), teratogenic potential, peripheral edema
MOA: Inhibits __________ and interferes with the RELEASE of progeny influenza virus (early administration crucial)
Active against BOTH Influenza A and B
SE: anaphylaxis (hypersensitivity), infections, skin reactions, GI symptoms
Anti-influenza agent classes
Conditions increasing hospitalization rates by 4-5X
A nucleoside analog that interferes with the synthesis of guanosine/adenosine triphosphate, inhibits capping of viral mRNA; inhibits viral RNA polymerase. Phosphorylated (activated

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Created Apr 13, 2011ReportNominate