anti-viral agents

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Can you name the anti-viral agents?

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Anti-influenza agent classes
SE: hemolytic anemia, skin rash, depression, fatigue, irritability, nausea, insomnia
Active against Influenza A only
M2 Inhibitors
Contraindicated in pts with uncorrected anemia, end-stage renal failure, ischemia vascular dz, and pregnancy
Adverse reactions: GI upset, CNS (dopaminergic effects), teratogenic potential, peripheral edema
RSV agent used only for prophylaxis
Use: For the prophylaxis and tx (if taken within 2 days of symptoms)
Conditions increasing hospitalization rates by 4-5X
Negative sense, single-stranded RNA virus
Used in children with severe RSV to minimize bronchiolitis or PNA.
Agent(s) used in the chemoprophylaxis and treatment of influenza A (if administered early). Also can be used in the tx of Parkinson's dz
AVOID in asthma and COPD
SE: GI symptoms and psychological effects
Hospitalizes 2-3% of infants in the first 12 months of life
100% resistance with seasonal H3N2 and 2009 pandemic flu
Oral bioavailability is increased with high fat meal and decreased with antacid
Agents used in RSV infections
Neuroaminidase Inhibitors
Most common cause of bronchiolitis and PNA in children < 1 y.o.
Active against BOTH Influenza A and B
________ + peg IFN alpha-2A = standard tx for HCV
SE: anaphylaxis (hypersensitivity), infections, skin reactions, GI symptoms
A humanized monoclonal Ab directed against an epitope in the A antigen site on the F fusion protein of RSV (blocks VIRAL ENTRY to host cells)
A nucleoside analog that interferes with the synthesis of guanosine/adenosine triphosphate, inhibits capping of viral mRNA; inhibits viral RNA polymerase. Phosphorylated (activated
Blocks ___ ion channels and INHIBITS UNCOATING
MOA: Inhibits __________ and interferes with the RELEASE of progeny influenza virus (early administration crucial)
SE: bronchospasm and psychological effects

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