anti-viral agents

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Can you name the anti-viral agents?

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100% resistance with seasonal H3N2 and 2009 pandemic flu
SE: bronchospasm and psychological effects
Active against BOTH Influenza A and B
Agent(s) used in the chemoprophylaxis and treatment of influenza A (if administered early). Also can be used in the tx of Parkinson's dz
SE: anaphylaxis (hypersensitivity), infections, skin reactions, GI symptoms
Adverse reactions: GI upset, CNS (dopaminergic effects), teratogenic potential, peripheral edema
A humanized monoclonal Ab directed against an epitope in the A antigen site on the F fusion protein of RSV (blocks VIRAL ENTRY to host cells)
Conditions increasing hospitalization rates by 4-5X
AVOID in asthma and COPD
RSV agent used only for prophylaxis
MOA: Inhibits __________ and interferes with the RELEASE of progeny influenza virus (early administration crucial)
Neuroaminidase Inhibitors
M2 Inhibitors
Used in children with severe RSV to minimize bronchiolitis or PNA.
Negative sense, single-stranded RNA virus
Agents used in RSV infections
Blocks ___ ion channels and INHIBITS UNCOATING
Active against Influenza A only
SE: GI symptoms and psychological effects
Use: For the prophylaxis and tx (if taken within 2 days of symptoms)
Contraindicated in pts with uncorrected anemia, end-stage renal failure, ischemia vascular dz, and pregnancy
Anti-influenza agent classes
Hospitalizes 2-3% of infants in the first 12 months of life
A nucleoside analog that interferes with the synthesis of guanosine/adenosine triphosphate, inhibits capping of viral mRNA; inhibits viral RNA polymerase. Phosphorylated (activated
________ + peg IFN alpha-2A = standard tx for HCV
SE: hemolytic anemia, skin rash, depression, fatigue, irritability, nausea, insomnia
Most common cause of bronchiolitis and PNA in children < 1 y.o.
Oral bioavailability is increased with high fat meal and decreased with antacid

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Created Apr 13, 2011ReportNominate