anti-viral agents

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Can you name the anti-viral agents?

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SE: hemolytic anemia, skin rash, depression, fatigue, irritability, nausea, insomnia
Use: For the prophylaxis and tx (if taken within 2 days of symptoms)
SE: GI symptoms and psychological effects
Negative sense, single-stranded RNA virus
MOA: Inhibits __________ and interferes with the RELEASE of progeny influenza virus (early administration crucial)
Contraindicated in pts with uncorrected anemia, end-stage renal failure, ischemia vascular dz, and pregnancy
Hospitalizes 2-3% of infants in the first 12 months of life
________ + peg IFN alpha-2A = standard tx for HCV
Most common cause of bronchiolitis and PNA in children < 1 y.o.
M2 Inhibitors
SE: anaphylaxis (hypersensitivity), infections, skin reactions, GI symptoms
Active against BOTH Influenza A and B
RSV agent used only for prophylaxis
Adverse reactions: GI upset, CNS (dopaminergic effects), teratogenic potential, peripheral edema
AVOID in asthma and COPD
Blocks ___ ion channels and INHIBITS UNCOATING
Anti-influenza agent classes
A humanized monoclonal Ab directed against an epitope in the A antigen site on the F fusion protein of RSV (blocks VIRAL ENTRY to host cells)
SE: bronchospasm and psychological effects
Neuroaminidase Inhibitors
Agents used in RSV infections
100% resistance with seasonal H3N2 and 2009 pandemic flu
Active against Influenza A only
A nucleoside analog that interferes with the synthesis of guanosine/adenosine triphosphate, inhibits capping of viral mRNA; inhibits viral RNA polymerase. Phosphorylated (activated
Used in children with severe RSV to minimize bronchiolitis or PNA.
Oral bioavailability is increased with high fat meal and decreased with antacid
Agent(s) used in the chemoprophylaxis and treatment of influenza A (if administered early). Also can be used in the tx of Parkinson's dz
Conditions increasing hospitalization rates by 4-5X

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Created Apr 13, 2011ReportNominate