anti-viral agents

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Can you name the anti-viral agents?

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MOA: Inhibits __________ and interferes with the RELEASE of progeny influenza virus (early administration crucial)
Hospitalizes 2-3% of infants in the first 12 months of life
AVOID in asthma and COPD
SE: bronchospasm and psychological effects
Active against BOTH Influenza A and B
Use: For the prophylaxis and tx (if taken within 2 days of symptoms)
Blocks ___ ion channels and INHIBITS UNCOATING
Agents used in RSV infections
Active against Influenza A only
100% resistance with seasonal H3N2 and 2009 pandemic flu
________ + peg IFN alpha-2A = standard tx for HCV
SE: hemolytic anemia, skin rash, depression, fatigue, irritability, nausea, insomnia
Conditions increasing hospitalization rates by 4-5X
Neuroaminidase Inhibitors
Anti-influenza agent classes
RSV agent used only for prophylaxis
Adverse reactions: GI upset, CNS (dopaminergic effects), teratogenic potential, peripheral edema
Contraindicated in pts with uncorrected anemia, end-stage renal failure, ischemia vascular dz, and pregnancy
Used in children with severe RSV to minimize bronchiolitis or PNA.
Oral bioavailability is increased with high fat meal and decreased with antacid
A humanized monoclonal Ab directed against an epitope in the A antigen site on the F fusion protein of RSV (blocks VIRAL ENTRY to host cells)
Agent(s) used in the chemoprophylaxis and treatment of influenza A (if administered early). Also can be used in the tx of Parkinson's dz
Most common cause of bronchiolitis and PNA in children < 1 y.o.
SE: GI symptoms and psychological effects
A nucleoside analog that interferes with the synthesis of guanosine/adenosine triphosphate, inhibits capping of viral mRNA; inhibits viral RNA polymerase. Phosphorylated (activated
M2 Inhibitors
SE: anaphylaxis (hypersensitivity), infections, skin reactions, GI symptoms
Negative sense, single-stranded RNA virus

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