Anti-hepatitis Agents

Random Miscellaneous Quiz

Can you name the Anti-hepatitis Agents?

Quiz not verified by Sporcle

How to Play
Also try: 'Q', 'X', 'Z' Game
Challenge
Share
Tweet
Embed
HintAnswer
MOA: A prodrug (a guanosine nucleoside analogue). Phosphorylated by host cell enzymes; inhibits viral RNA-dependent polymerases.
MOA: An adenosine analogue. Structurally similar to adefovir.
Use: Lamivudine-resistant HBV. Adults only
P-kinetics: Oral bioavailability increased with high-fat meal, decreased with antacid.
SE: Flu-like symptoms (fever, chills, myalgias, malaise). Neurotoxicity, myelosuppression, fatigue (chronic use). Transient hepatic enzyme elevation.
Group MOA cont. (3) Protein kinase (activated by dsRNA): phosphorylates/inhibits eIF-2, therefore blocking PRO synthesis
Use: The most potent anti-HBV agent. Adults only
PEG-IFN α-2a Class
P-kinetics: Oral (TID). P450 substrates (potential rx interactions)
MOA: A guanisine analog. Inhibits all 3 functions of HBV RNA-dependent DNA polymerase (base priming, reverse transcription of the -strand, synthesis of the + strand of HBV DNA.
MOA: A cytosine analogue
Use: Effective suppression of HBV DNA, normalization of ALT & reducing HBeAg. Adults only
MOA: A thymidine analog
MOA: A prodrug of adefovir (adenosine analogue). Slows suppression of HBV DNA; least seroconversion
Group P-kinetics: Pills once a day for a year or longer
P-kinetics: Natural. SC or IM
P-kinetics: Slower clearance (less frequent dosing). Dosage adjustment is needed in renal dysfunction
SE: HA, fatigue, nausea. Potential mitochondrial toxicity (lactic acidosis & hepatic steatosis)
Contraindications: Hepatic decompensation, autoimmune dz, cardiac arrhythmia, pregnancy
Adefovir dipivoxil (Hepsera) Class
Group MOA: 3 major enzymes are activated by IFN-JNK/STAT signaling pathway: (1) 2',5' oligo A synthase: produces 2'5' oligo A.
P-kinetics: Prolonged intracellular half-life in HBV (than in HIV). Rapid oral absorption; eliminated unchanged. Used at lower doses for hepatitis than for AIDS.
Use: HBV: Safer for pts w/ decompensated liver dz. For both adults & peds
Group MOA cont: Associated with mitochondrial DNA toxicity (by inhibiting DNA polymerase gamma)
SE: Anemia, neutropenia, dysgeusia, skin rash (esp. telaprevir), increased QT intervals (telaprevir)
HintAnswer
Boceprevir Class
P-kinetics: Lipophilic (pivoxil) moiety enhances oral bioavailability.
Telbivudine (Tyzeka) Class
MOA: Serine protease inhibitors. Bind to inhibit HCV non-structural protein NS3
P-kinetics: Synthetic (consensus). SC
Contraindications: Pts w/ uncorrected anemia, ESRD, preggo. Teratogenic: avoid pregnancy for > 6 mos thereafter
P-kinetics: Higher rate of complete response & less resistance vs. adefovir
SE: Nephrotoxicity (at high doses). Potential mitochondrial DNA toxicity
SE: Increased pancreatitis in HIV/HBV pts. Emergence of resistance (mutations of DNA polymerase)
Entecavir (Baraclude) Class
Telaprevir Class
IFN α-2a/2b class
Use: Improve therapeutic response in pts (>18 yo) w/ HCV genotype 1 when combined w/ IFN/ribavirin
Lamivudine (3TC, Heptovir) Class
IFN α-2b Class
SE: Dose-dependent hemolytic anemia. Depression, fatigue, irritability, nausea, insomnia.
Group MOA: Competively inhibit HBV DNA polymerase +/- incorporate into viral DNA causing chain termination. Phosphorylated to active forms intracellularly by cellular kinases.
PEG-IFN α-2a/2b class
Use: HBV treatment adults only
IFN alfacon-1 class
P-kinetics: Clinical resistance is rare. Oral bioavailability decreased by food (taken w/ empty stomach). Renal elimination (serum concentration increased w/ altered kidney activit
Group MOA cont. (2) Ribonuclease L (activated by 2'5' oligo A): degrades mRNA.
P-kinetics:Oral bioavailability not affected by food. Emergence of resistance in long term use.
Tenofovir Class
Drug MOA: PEG = polyethylene glycol

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Sign Up with Email
OR
Log In

You Might Also Like...

Show Comments

Extras


Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.