Anti-glycemic Agents

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Can you name the Anti-glycemic Agents?

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Humulin 50/50
Nololin 70/30
P-kinetics: Eliminated by renal filtration
Use: Combines rapid-acting and intermediate-acting insulin. Controls blood sugar at mealtime and all day and night
Use: Onset and duration are rough within the range listed from person to person
MOA: Inhibit enzymatic degradation of incretin hormones. Unlike most PO meds for DM, does not promote wt gain, there may even be slight wt loss.
Sitagliptin (Januvia) class
Rosiglitazone (Avandia) class
MOA: Effective in long-duration DM, weight loss, no hypoglycemia, lowers insuling, TG, LDL
Pioglitazone (Actos) class
Humulin R (Lilly) class
P-kinetics: Injected SQ BID
Novolin 70/30 PenFill
Novolog Mix 70/30 class
Metformin and glyburide combo
Use: Controls blood sugar surges at mealtime
Duration 3 - 4 hours (4-5 hours)
SE: Nausea, other GI effects, rare reports of pancreatitis
Novolin R (Novo Nordisk) class
Humulin L (Lente) (Lilly) class
Humulin 70/30
Duration ~14 hours
Novolin 70/30 class
Duration: 18-20 hours
Novolog Mix 70/30 PenFill class
Novolog Mix 70/30 class
Exenatide class
SE: GI effects, increased transaminases (monitor). No hypoglycemia
MOA: Increases hepatic insulin sensitivity. Works through AMP dependent kinase, a mastor allosteric regulator of metabolism, that senses lack of energy substrates in cells.
Metformin class
Humulin N class
Glusine - Apidra (Avemtis) class
Repalinide class
Metformin and glipizide combo
SE: Similar to sulfonureas but with less risk of prolonged hypoglycemia.
Peak 6-8 hours
Duration: 20-24 hours
MOA: Decreases hepatic glucose production, decreases peripheral insulin resistance, increases glucose uptake, decrease gluconeogenesis, decreases fatty liver,
MOA: Bind to SU receptor on surface of beta cells, closing K+ATP channels -> to depolarization of cell membrane, allowing Ca++ to enter cell -> in insulin secretion.
Glipizide (Glucotrol; Glucotrol XL) class
Humalog Mix 50/50 class
Onset 1-4 hours
MOA: GLP-1 agonist. Has all the properties of human GLP-1. 10 lb or greater wt loss in 1 yr
Rosiglitazone and metformin combo
MOA: Decreases insulin resistance, increase muscle and adipose tissue glucose uptake, decreased hepatic glucose output.
Onset: 1-2 hours
Metformin and pioglitazone combo
Contraindications: Class III/IV CHF
MOA: Binds to PPAR-gamma, a nuclear receptor regulating differentiation of cells (adipocytes, vascular tissue). Decreased plasma fatty acid levels, decreased central adiposity, res
Novolin N class
SE: No hypoglycemia
NPH Iletin III (Lilly) class
Sitagliptin and metformin combo
Glimepiride (Amaryl) class
Humulin Br class
Regular Ileting II (Lilly) class
Onset 30 minutes - 1 hour
Humalog 50/50 class
MOA: Lowers threshold for insulin release. Effective early; secondary failure common.
Avapro - Novalog (Novo Nordisk) class
Novolin R PenFill
Apidra class
Duration 5-7 hours (6 - 8 hours)
MOA: Similar to sulfonureas.
Peak 2 - 5 hours
P-kinetics: Rapid absorption, short duration.
SE: Hypoglycemia, weight gain, GI effects.
Nolvin N PenFill
P-kinetics: 100 mg once daily
Peak: 1 hour
SE: GI effects, occasional low B12, rare lactic acidosis, ovulation in PCO
Use: DM II. Most effective in lean patients.
Glargine - Lantus class
MOA: Lowers postprandial glucose rise by delaying CHO absorption. Decreases glucose absorption secondary to decreased digestion of carbohydrates.
Contraindications: Intestinal dz, cirrhosis, renal dz (creatinine > 2)
Acarbose class
Use: Controls blood sugar between meals and during sleep
Contraindications: Renal dz, liver dz, CHF, dehydration, shock, acidosis, alcoholism
Onset 15-30 minutes
Humalog 75/25 Mix class
Peak: None
Duration 18-24 hours (12-16 hours)
Lispro - Humalog (Lilly) class
Use: First-line for most DM II, esp. obese.
Detemir - Levemir class
Humalog class
Novolog class
Humulin N (NPH) (Lilly) class
Pioglitazone and glimepiride combo
Humulin Ultralente class
Rosiglitazone and glimepiride combo
Novolin R class
Use: Human insulin is made by recombinant technology
Glyburide (Micronase, Diabeta) class
Miglitol class
Humalog Mix 75/25 class
Nololin N (NPH) (Lilly) class
SE: Increased plasma volume, edema, CHF, ovulation in PCO, mild anemia, rare liver toxicity, risk of fx in women. No hypoglycemia
Nolovin R PenFill

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Created Jan 16, 2012ReportNominate