| Hint | Answer |
|---|
| Use: First-line for most DM II, esp. obese. | |
| Humalog class | |
| Onset 15-30 minutes | |
| Novolin 70/30 PenFill | |
| Glimepiride (Amaryl) class | |
| P-kinetics: Eliminated by renal filtration | |
| Novolog Mix 70/30 class | |
| P-kinetics: Injected SQ BID | |
| Humulin Ultralente class | |
| Nolvin N PenFill | |
| P-kinetics: 100 mg once daily | |
| MOA: Inhibit enzymatic degradation of incretin hormones. Unlike most PO meds for DM, does not promote wt gain, there may even be slight wt loss. | |
| SE: Similar to sulfonureas but with less risk of prolonged hypoglycemia. | |
| Duration 5-7 hours (6 - 8 hours) | |
| SE: No hypoglycemia | |
| Lispro - Humalog (Lilly) class | |
| Pioglitazone and glimepiride combo | |
| Novolog Mix 70/30 PenFill class | |
| Peak 6-8 hours | |
| Humalog Mix 50/50 class | |
| P-kinetics: Rapid absorption, short duration. | |
| Regular Ileting II (Lilly) class | |
| MOA: Similar to sulfonureas. | |
| Nololin N (NPH) (Lilly) class | |
| Repalinide class | |
| Humulin N class | |
| Nololin 70/30 | |
| Rosiglitazone (Avandia) class | |
| Humulin Br class | |
| Novolin N class | |
| Contraindications: Renal dz, liver dz, CHF, dehydration, shock, acidosis, alcoholism | |
| Onset: 1-2 hours | |
| SE: Increased plasma volume, edema, CHF, ovulation in PCO, mild anemia, rare liver toxicity, risk of fx in women. No hypoglycemia | |
| | Hint | Answer |
|---|
| Use: Human insulin is made by recombinant technology | |
| Humulin R (Lilly) class | |
| Novolin R class | |
| Use: Controls blood sugar between meals and during sleep | |
| Metformin and pioglitazone combo | |
| Contraindications: Class III/IV CHF | |
| Glyburide (Micronase, Diabeta) class | |
| Detemir - Levemir class | |
| NPH Iletin III (Lilly) class | |
| Humalog 50/50 class | |
| Apidra class | |
| Glusine - Apidra (Avemtis) class | |
| Novolin R (Novo Nordisk) class | |
| Metformin and glipizide combo | |
| Humulin 50/50 | |
| Miglitol class | |
| Humulin 70/30 | |
| MOA: Lowers threshold for insulin release. Effective early; secondary failure common. | |
| Metformin class | |
| Use: Onset and duration are rough within the range listed from person to person | |
| Metformin and glyburide combo | |
| MOA: GLP-1 agonist. Has all the properties of human GLP-1. 10 lb or greater wt loss in 1 yr | |
| Novolin R PenFill | |
| MOA: Decreases insulin resistance, increase muscle and adipose tissue glucose uptake, decreased hepatic glucose output. | |
| Use: Controls blood sugar surges at mealtime | |
| SE: Nausea, other GI effects, rare reports of pancreatitis | |
| Glargine - Lantus class | |
| Humulin N (NPH) (Lilly) class | |
| SE: GI effects, increased transaminases (monitor). No hypoglycemia | |
| MOA: Effective in long-duration DM, weight loss, no hypoglycemia, lowers insuling, TG, LDL | |
| Peak 2 - 5 hours | |
| Novolin 70/30 class | |
| Rosiglitazone and glimepiride combo | |
| | Hint | Answer |
|---|
| Duration 3 - 4 hours (4-5 hours) | |
| SE: Hypoglycemia, weight gain, GI effects. | |
| Rosiglitazone and metformin combo | |
| Sitagliptin and metformin combo | |
| Onset 1-4 hours | |
| Duration: 20-24 hours | |
| SE: GI effects, occasional low B12, rare lactic acidosis, ovulation in PCO | |
| Duration 18-24 hours (12-16 hours) | |
| Peak: None | |
| MOA: Bind to SU receptor on surface of beta cells, closing K+ATP channels -> to depolarization of cell membrane, allowing Ca++ to enter cell -> in insulin secretion. | |
| Acarbose class | |
| Onset 30 minutes - 1 hour | |
| Novolog class | |
| MOA: Decreases hepatic glucose production, decreases peripheral insulin resistance, increases glucose uptake, decrease gluconeogenesis, decreases fatty liver, | |
| Peak: 1 hour | |
| Use: DM II. Most effective in lean patients. | |
| Contraindications: Intestinal dz, cirrhosis, renal dz (creatinine > 2) | |
| Humulin L (Lente) (Lilly) class | |
| Humalog 75/25 Mix class | |
| MOA: Binds to PPAR-gamma, a nuclear receptor regulating differentiation of cells (adipocytes, vascular tissue). Decreased plasma fatty acid levels, decreased central adiposity, res | |
| MOA: Lowers postprandial glucose rise by delaying CHO absorption. Decreases glucose absorption secondary to decreased digestion of carbohydrates. | |
| Use: Combines rapid-acting and intermediate-acting insulin. Controls blood sugar at mealtime and all day and night | |
| Duration: 18-20 hours | |
| MOA: Increases hepatic insulin sensitivity. Works through AMP dependent kinase, a mastor allosteric regulator of metabolism, that senses lack of energy substrates in cells. | |
| Nolovin R PenFill | |
| Novolog Mix 70/30 class | |
| Duration ~14 hours | |
| Sitagliptin (Januvia) class | |
| Avapro - Novalog (Novo Nordisk) class | |
| Humalog Mix 75/25 class | |
| Pioglitazone (Actos) class | |
| Glipizide (Glucotrol; Glucotrol XL) class | |
| Exenatide class | |
|
Famous Foursomes
'A' Game
Fast Food Restaurants
