| Hint | Answer |
|---|
| SE: Well tolerated. HA, dizziness, and constipation. Prolongation of QT interval (esp. dolasetron) | |
| Granisetron class | |
| MOA: Central dopaminergic blockade | |
| SE: Euphoria, dysphoria, sedation, hallucination, dry mouth, increased appetite, autonomic effects tachycardia, orthostatic hypotension | |
| Use: Prevention of motion sickness | |
| Use: Appetite stimulant & as an antiemetic | |
| Dronabinol class | |
| Methylprednisone class | |
| Hyoscine class | |
| Dimenhydrinate class | |
| MOA: Serotonin is released by the enterochromaffin cells of the small intestine in response to chemo agents & may stim vagal afferents (via 5-HT3-R) to initiate the vomiting reflex | |
| SE: Dizziness, sedation, confusion, dry mouth, cycloplegia, urinary retention. Meclizine has less anticholinergic SE than dimenhydrinate or diphenhydramine | |
| Palonosetron class | |
| Aprepitant class | |
| MOA: The major psychoactive chemical (THC) in marijuana | |
| Lorazepam class | |
| Prochlorperazine class | |
| Thiethylperazine class | |
| Droperidol class | |
| Dexamethasone class | |
| Use: Anti-emetic / sedative | |
| Use: Chemo-induced n/v. Post-op and post-radiation n/v | |
| Promethazine class | |
| MOA: Central blockade in the area postrema. Substance P antagonist. Highly selective NK1-R antagonist that crosses BBB & occupies brain NK1-R | |
| | Hint | Answer |
|---|
| P-kinetics: Long half-life ~ 40 hours | |
| SE: EPS | |
| MOA: Bind to GABA receptor and increase the frequency of the chloride ion channel opening at the GABA-R | |
| MOA cont: The 5-HT3 receptor antagonists suppress n/v by inhibiting serotonin binding to the 5-HT3 receptors. No effect on dopamine or muscarinic receptors. No effect on esophageal | |
| Use: In combo w/ 5-HT3-R antagonists & dexametasone for the prevention of acute & delayed n/v from chemo regimens. | |
| MOA: Inhibit dopamine & muscarinic (anti-emetic). Antihistamine activity (sedative) | |
| P-kinetics: Metabolized by CYP3A4 & may inhibit other drug metabolism by the CYP3A4 pathway | |
| Use: Useful for the prevention / tx of motion sickness | |
| MOA: Muscarinic receptor antagonist | |
| Use: Antiemetic / prokinetic | |
| Dolasetron class | |
| MOA: Histamine antagonists | |
| MOA: Dopamine-R blockade. Appears to bind to dopamine D2-R & is also a mixed 5-HT3-R antagonist/5-HT4-R agonist. | |
| May prolong QT interval | |
| Meclizine class | |
| Metoclopramide class | |
| Use: Used prior to chemo to decrease anxiety-induced vomiting | |
| Ondansetron class | |
| SE: EPS & hypotension. | |
| Nabilone class | |
| SE: High anticholinergic effects (TD patches are better tolerated) | |
| Diazepam class | |
| Diphenhydramine class | |
| SE: Fatigue, dizziness, diarrhea | |
|
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