| Event | Year | Description |
| Defeat of Breton resistance | |
| Treaty of Blois | |
| Philip II's successful invasion of Portugal | |
| Warbeck's arrival in Flanders and the subsequent embargo on trade with the Netherlands | |
| Mary Queen of Scots abdication | |
| Death of Isabella of Castille | |
| Seizure of Genoese treasure ships bound for the Netherlands | |
| Death of Henry VIII and accession of Edward VI (month) | |
| Treaty of Troyes | |
| Elizabeth's rejection of sovereignty in the Netherlands | |
| Death of Charles IX and accession of Henri III | |
| Loss of Calais | |
| Death of Wolsey (month) | |
| Marriage of Prince Arthur and Catherine of Aragon | |
| Death of Arthur (month) | |
| Massacre of Hawkins' men at San Juan D'Ulua | |
| Henry VIII's second war with France (inclusive dates of duration) | |
| Death of Elizabeth of York | |
| Death of Emperor Maximilian and the election of Charles to the throne of the HRE | |
| The Prayer Book Rebellion or western uprising | |
| reconciliation of southern Netherland's provinces with Philip II | |
| James IV's invasion in support of Warbeck | |
| Assassination of Henri III and accession of Henry IV | |
| 7 year truce of Ayton with Scotland | |
| Battle of Pinkie | |
| Spanish landing at Kinsdale, Ireland | |
| Death of Francis II and accession of Charles IX under regency | |
| Battle of Flodden (month) | |
| Death of Mary I and accession of Elizabeth I | |
| Treaty of Hampton court with Huguenots | |
| Assassination of William of Orange | |
| Treaty of Boulogne | |