Tumor Supressor Genes (Goljan Table 8-4)

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Can you name the Tumor Supressor Genes (Goljan Table 8-4)?

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Gene product regulates DNA repair
Gene product Prevents nuclear transcription (degrades catenin, an activator of nuclear transcription)
Lung colon, breast carcinomas
Cerebellar hemang, retinal angioma, bilat RCC and PCC
Syndrome of brain tumors, sarcomas, breast carcinoma, an leukemia
activated by p53 product to promote apoptosis
Li Fraumeni
Gene product inhibits going from G1-S (not Rb or p53)
Regulates nuclear transcription (not WT1)
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OSTEOSARCOMA, breast carcinoma, retinoblastoma
Familial polyposis
Regulates nuclear transcription (not VHL)
Product activates BAX gene and subsequent apoptosis; also inhib G1-S
Wilms' tumor
Gene product inhibits going from G1-S (not TGF beta or p53)
Pancreatic and colorectal carcinomas
Syndrome of Cerebellar hemang, retinal angioma, bilat RCC and PCC
Breast, ovary carcinomas

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