Tumor Supressor Genes (Goljan Table 8-4)

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Can you name the Tumor Supressor Genes (Goljan Table 8-4)?

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Product activates BAX gene and subsequent apoptosis; also inhib G1-S
Gene product inhibits going from G1-S (not TGF beta or p53)
Regulates nuclear transcription (not WT1)
Pancreatic and colorectal carcinomas
Gene product Prevents nuclear transcription (degrades catenin, an activator of nuclear transcription)
OSTEOSARCOMA, breast carcinoma, retinoblastoma
Regulates nuclear transcription (not VHL)
Syndrome of brain tumors, sarcomas, breast carcinoma, an leukemia
Wilms' tumor
InfoAnswerdetails
Gene product regulates DNA repair
Lung colon, breast carcinomas
Familial polyposis
Li Fraumeni
Syndrome of Cerebellar hemang, retinal angioma, bilat RCC and PCC
Breast, ovary carcinomas
Gene product inhibits going from G1-S (not Rb or p53)
Cerebellar hemang, retinal angioma, bilat RCC and PCC
activated by p53 product to promote apoptosis

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