Tumor Supressor Genes (Goljan Table 8-4)

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Can you name the Tumor Supressor Genes (Goljan Table 8-4)?

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Gene product inhibits going from G1-S (not Rb or p53)
Regulates nuclear transcription (not WT1)
Gene product regulates DNA repair
Familial polyposis
Product activates BAX gene and subsequent apoptosis; also inhib G1-S
Lung colon, breast carcinomas
Gene product inhibits going from G1-S (not TGF beta or p53)
Gene product Prevents nuclear transcription (degrades catenin, an activator of nuclear transcription)
Pancreatic and colorectal carcinomas
InfoAnswerdetails
Regulates nuclear transcription (not VHL)
OSTEOSARCOMA, breast carcinoma, retinoblastoma
Li Fraumeni
Wilms' tumor
Syndrome of brain tumors, sarcomas, breast carcinoma, an leukemia
Breast, ovary carcinomas
activated by p53 product to promote apoptosis
Syndrome of Cerebellar hemang, retinal angioma, bilat RCC and PCC
Cerebellar hemang, retinal angioma, bilat RCC and PCC

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