Science / Tumor Supressor Genes (Goljan Table 8-4)

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Can you name the Tumor Supressor Genes (Goljan Table 8-4)?

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Cerebellar hemang, retinal angioma, bilat RCC and PCC
Syndrome of Cerebellar hemang, retinal angioma, bilat RCC and PCC
Familial polyposis
Gene product regulates DNA repair
Lung colon, breast carcinomas
Li Fraumeni
Gene product Prevents nuclear transcription (degrades catenin, an activator of nuclear transcription)
Gene product inhibits going from G1-S (not Rb or p53)
Pancreatic and colorectal carcinomas
InfoAnswerdetails
OSTEOSARCOMA, breast carcinoma, retinoblastoma
Regulates nuclear transcription (not WT1)
activated by p53 product to promote apoptosis
Product activates BAX gene and subsequent apoptosis; also inhib G1-S
Breast, ovary carcinomas
Syndrome of brain tumors, sarcomas, breast carcinoma, an leukemia
Regulates nuclear transcription (not VHL)
Gene product inhibits going from G1-S (not TGF beta or p53)
Wilms' tumor

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