Science / Tumor Supressor Genes (Goljan Table 8-4)

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Can you name the Tumor Supressor Genes (Goljan Table 8-4)?

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Forced Order
Gene product inhibits going from G1-S (not TGF beta or p53)
Syndrome of brain tumors, sarcomas, breast carcinoma, an leukemia
Regulates nuclear transcription (not VHL)
Gene product Prevents nuclear transcription (degrades catenin, an activator of nuclear transcription)
Gene product regulates DNA repair
Breast, ovary carcinomas
Regulates nuclear transcription (not WT1)
OSTEOSARCOMA, breast carcinoma, retinoblastoma
Gene product inhibits going from G1-S (not Rb or p53)
Lung colon, breast carcinomas
Product activates BAX gene and subsequent apoptosis; also inhib G1-S
Wilms' tumor
Li Fraumeni
Pancreatic and colorectal carcinomas
Syndrome of Cerebellar hemang, retinal angioma, bilat RCC and PCC
activated by p53 product to promote apoptosis
Cerebellar hemang, retinal angioma, bilat RCC and PCC
Familial polyposis

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