Tumor Supressor Genes (Goljan Table 8-4)

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Can you name the Tumor Supressor Genes (Goljan Table 8-4)?

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InfoAnswerdetails
Gene product regulates DNA repair
Syndrome of Cerebellar hemang, retinal angioma, bilat RCC and PCC
Cerebellar hemang, retinal angioma, bilat RCC and PCC
Lung colon, breast carcinomas
Syndrome of brain tumors, sarcomas, breast carcinoma, an leukemia
Product activates BAX gene and subsequent apoptosis; also inhib G1-S
activated by p53 product to promote apoptosis
Gene product inhibits going from G1-S (not TGF beta or p53)
Regulates nuclear transcription (not VHL)
InfoAnswerdetails
Pancreatic and colorectal carcinomas
Familial polyposis
Gene product Prevents nuclear transcription (degrades catenin, an activator of nuclear transcription)
Gene product inhibits going from G1-S (not Rb or p53)
Regulates nuclear transcription (not WT1)
Wilms' tumor
Breast, ovary carcinomas
OSTEOSARCOMA, breast carcinoma, retinoblastoma
Li Fraumeni

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