Science / Tumor Supressor Genes (Goljan Table 8-4)

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Can you name the Tumor Supressor Genes (Goljan Table 8-4)?

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Wilms' tumor
Regulates nuclear transcription (not WT1)
Breast, ovary carcinomas
Product activates BAX gene and subsequent apoptosis; also inhib G1-S
OSTEOSARCOMA, breast carcinoma, retinoblastoma
Familial polyposis
activated by p53 product to promote apoptosis
Gene product regulates DNA repair
Gene product Prevents nuclear transcription (degrades catenin, an activator of nuclear transcription)
Li Fraumeni
Pancreatic and colorectal carcinomas
Lung colon, breast carcinomas
Gene product inhibits going from G1-S (not Rb or p53)
Cerebellar hemang, retinal angioma, bilat RCC and PCC
Regulates nuclear transcription (not VHL)
Syndrome of brain tumors, sarcomas, breast carcinoma, an leukemia
Syndrome of Cerebellar hemang, retinal angioma, bilat RCC and PCC
Gene product inhibits going from G1-S (not TGF beta or p53)

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