Tumor Supressor Genes (Goljan Table 8-4)

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Can you name the Tumor Supressor Genes (Goljan Table 8-4)?

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InfoAnswerdetails
Product activates BAX gene and subsequent apoptosis; also inhib G1-S
Gene product inhibits going from G1-S (not TGF beta or p53)
Pancreatic and colorectal carcinomas
Li Fraumeni
Regulates nuclear transcription (not VHL)
Breast, ovary carcinomas
Gene product inhibits going from G1-S (not Rb or p53)
Regulates nuclear transcription (not WT1)
Syndrome of brain tumors, sarcomas, breast carcinoma, an leukemia
InfoAnswerdetails
Wilms' tumor
Gene product Prevents nuclear transcription (degrades catenin, an activator of nuclear transcription)
Familial polyposis
Syndrome of Cerebellar hemang, retinal angioma, bilat RCC and PCC
Gene product regulates DNA repair
OSTEOSARCOMA, breast carcinoma, retinoblastoma
activated by p53 product to promote apoptosis
Cerebellar hemang, retinal angioma, bilat RCC and PCC
Lung colon, breast carcinomas

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