Papulosquamous and Skin neoplasia

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Characteristics Answerdetails
organized brown􏰀nodules􏰀of􏰀fibroblasts􏰀invading􏰀the􏰀SC􏰀tissue (vs dermatofibroma, which stays in dermis, IE, is not malignant)dermatofibrosarcoma protuberans; malignant
Most􏰀common􏰀type􏰀of􏰀melanoma􏰀in􏰀dark􏰁skinned􏰀patients􏰀(AA);􏰀occurs􏰀on􏰀hands􏰀&􏰀feet; thick epidermis on feetAcral lentiginous melanoma, ALM
brown􏰀papules􏰀(raised􏰀&􏰀pigmented);􏰀present􏰀at􏰀both at􏰀the􏰀epidermal􏰁dermal􏰀junction􏰀 &􏰀in􏰀the􏰀dermisnevus
speckled patch acquired in childhoodbenign, but may degenerate to melanoma
retention of nuclei within the keratinosisparakeratosis; psoriasis
halo nevi associated with what 2 conditions in adults
Helper cells in psoriasisvs Th2s in eczematous conditions
EIC on scalppilar cyst
fleshy,􏰀pedunculated,􏰀papillomatous􏰀lesions; central􏰀connective􏰀tissue􏰀core􏰀covered􏰀by􏰀epithelial􏰀cells􏰀(aka􏰀fibro􏰁epithelial􏰀polyp); 'skiacrochordon, benign, epithelial origin
Bug in guttate psoriasisGroup A strep
melanocytic flesh􏰁colored papules􏰀(not􏰀pigmented!);􏰀confined􏰀to􏰀clusters􏰀within􏰀the􏰀dermisnevus
multiple large􏰀nevi􏰀with􏰀irregular pigmentation􏰀&􏰀irregular borders; irregularly􏰀'fried􏰁egg'􏰀looking􏰀melanocytes􏰀in􏰀the􏰀epidermal􏰁dermal􏰀j
brown􏰀macules (not􏰀raised!);􏰀confined􏰀to􏰀the􏰀epidermal􏰁dermal􏰀junctionnevus
Multiple􏰀EICs; FAP, mult soft tissue tumorsgardner's syndrome
firm, brown􏰀nodules􏰀on􏰀legs􏰀of􏰀middle􏰁aged􏰀women with􏰀'dimple􏰀sign'􏰀on􏰀compression; proliferation􏰀of􏰀fibroblasts􏰀in􏰀dermis (does􏰀NOTbenign fibrous histioma
bcc with scar-like plaques, called 'infiltrative'morpheaform
Predisposing factors to BCCSame as SCC
LP occuring􏰀on􏰀lower􏰀legs,􏰀extremely􏰀extremely􏰀itchyhypertrophic lichen planus
#1 soft tissue tumor in adultsbenign
Melanoma lacking pigmentation, spreading via nervesAmelanotic melanoma, hard to dx
Melanoma with worst prognosis;minvasive􏰀in􏰀dermis without􏰀intra􏰁epidermal􏰀involvement
Characteristics Answerdetails
common molejxnal, intradermal, compound
leser trelat assoc withor internal malignancy in general
Asymptomatic flesh􏰁colored􏰀papules􏰀(tiny􏰀bumps)􏰀that􏰀koebnerize; flexor􏰀surfaces of􏰀arms,􏰀trunk􏰀&􏰀penisLN
Multiple􏰀tiny􏰀white/yellow􏰀papules􏰀in􏰀newborns; variant of EIC, from diff part of hair follicle
Melanotic􏰀accumulation􏰀in􏰀mouth,􏰀lips,􏰀hands,􏰀genitalia; Polyps􏰀of􏰀colon􏰀&􏰀small􏰀intestine; ADpuetz jeghers
single􏰀itchy 'herald􏰀patch' plaques􏰀on􏰀trunk; then multiple􏰀symmetrical eruptions􏰀with􏰀'Christmas􏰀tree'􏰀pattern; negative RPR and VDRL pityriasis rosea
explosive onset of seborrheic keratosisleser, trelat, assoc with gastric adenocarcinoma
small􏰀red􏰀papules􏰀on􏰀skins; proliferation􏰀of􏰀dilated􏰀capillaries􏰀&􏰀venules􏰀in􏰀lobules; benignacq cherry....
rodent ulcer
'pearly'􏰀papule􏰀with􏰀telangiectasia􏰀(dilated􏰀vessels); clusters􏰀of􏰀dark􏰀cells􏰀with􏰀palisading􏰀of􏰀nuclei; NO METSbasal cell carcinoma
invasive proliferation􏰀of􏰀melanocytes􏰀into􏰀dermislentigo maligna melanoma
Asymptomatic small􏰀flat􏰁topped􏰀papules􏰀that􏰀spread􏰀along􏰀line􏰀of􏰀Blaschko on􏰀armLS
Precursor􏰀lesion􏰀to􏰀SCC􏰀due􏰀to􏰀excessive􏰀exposure􏰀to􏰀sunlightactinic keratosis; squamous cell proliferation
Variant􏰀of􏰀SCC􏰀with􏰀sudden􏰀onset􏰀&􏰀rapid􏰀growthmay resemble BCC
Which surfaces have psoriasis
dome􏰁shaped dermal􏰀cyst􏰀(tumor􏰀containing􏰀liquid) with􏰀central􏰀puncta􏰀(opening)􏰀leaking􏰀cheesy􏰀 material; epithelial􏰀cyst􏰀(a􏰀real􏰀cystepidermal inclusion cyst, 'sebaceous cyst'
virus assoc with Kaposifound in AIDS (HIV)
soft tissue tumors are of what origin
precursor􏰀lesion􏰀to􏰀LMMfreckle, lentigo maligna
􏰀increase􏰀of􏰀melanin􏰀pigment􏰀in􏰀basal keratinocytes,􏰀NO􏰀melanocyte􏰀hyperplasiafreckles
lacy􏰀Wickham's􏰀striae
Characteristics Answerdetails
'in situ SCC'Associated􏰀with􏰀arsenic exposure􏰀&􏰀increased􏰀incidence􏰀of􏰀internal􏰀malignancy; has not invaded dermis yet (in-situ)
Precursor􏰀lesion to􏰀malignant􏰀melanoma; flat at birth, thickens with agenevus
red􏰀scaling (hyperkeratosis)􏰀papules􏰀with􏰀'sandpaper􏰀feel'􏰀surface; epidermal􏰀atypia􏰀that􏰀does􏰀NOT􏰀involve􏰀full􏰁thickness􏰀&􏰀parakeratosactinic keratosis; percursor to SCC
multiple internal fibromas; cafe au laitaka Von Recksomething
Well􏰁defined,􏰀non􏰁itchy,􏰀red􏰀plaques􏰀(flat􏰀papules); Thick 'silvery􏰁white'􏰀scales􏰀&􏰀erythematous􏰀base
frecklesmelanocytic
scaling,􏰀indurated,􏰀ulcerated􏰀nodule􏰀'sore􏰀that􏰀doesn't􏰀heal'; islands􏰀of􏰀neoplastic􏰀epidermal􏰀cells􏰀with􏰀'keratin􏰀pearls'; can metssquamous cell carcinoma
firm,􏰀dermal nodular􏰀scars; proliferation􏰀of􏰀connective􏰀tissue􏰀(collagen)􏰀as􏰀a􏰀fibroblastic􏰀response􏰀to􏰀injury (e.g.􏰀ear􏰀piercing), Blacksif not bulging-> hypertrophic scar
brown􏰀macules􏰀on􏰀sun􏰁exposed􏰀skin; limited melanocyte􏰀hyperplasia in􏰀basal epidermisage spots
pigmented tumors of skin have what cellular originmelanocyte
benign proliferation of squamous cellsseborrheic keratosis
Well defined epidermal lesions with scales & symmetrical􏰀rashes (general term)PR, psoriasis, LP, LS, LN
multiple􏰀small􏰀SK􏰀on􏰀malar􏰀area of􏰀face􏰀in􏰀darker􏰀skinVariant of SK, Dermatosis papulosa nigra
Most􏰀common􏰀subtype of􏰀melanoma;􏰀occurs􏰀on􏰀trunk of􏰀men􏰀&􏰀posterior􏰀thigh of􏰀womensuperficial spreading melanoma
Predisposing factors to SCCSame as BCC
'slit􏰁like'􏰀spaces􏰀with􏰀RBC􏰀extravasation􏰀&􏰀hemosiderin􏰀deposition (greek men, HIV pts)HHV8
benign􏰀pigmented􏰀skin􏰀neoplasm􏰀that􏰀appears􏰀'stuck􏰁on'􏰀&􏰀verrucous; acanthosis􏰀with􏰀'horn􏰀pseudocyst'seborrheic keratosis
Characteristic􏰀parakeratosis􏰀(retention􏰀of􏰀nuclei); Epidermal􏰀proliferation􏰀with􏰀acanthosis􏰀(thickening); Spongiosis􏰀(epidermal􏰀edema)􏰀with􏰀􏰀
Best indicator of melanoma prognosisBreslow's thickness
hairy brown patch, fake nevus

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