Science / Endocrine drugs

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Can you name the Endocrinology histology?

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IndicationDrugContraindications, side effects and note
Paget's diseaseA cytotoxic antibiotic
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
PCOS (hirsutism)Hyperkalemia
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
Cortisol suppression tests, psoriasis, eczemaThinning skin
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
Kidney stones, idiopathic hypercalciuriaHypercalcemia
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
Osteoporosis (for increasing bone mass)Very expensive
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
IndicationDrugContraindications, side effects and note
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
HyperthyroidismDelayed hypothyroidism
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
Obesity (against fat absorption)Steatorrhea
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
T1DM and T2DMWeight gain, hypoglycemia
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
Obesity (against appetite)Depression, anxiety, nausea
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility

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