Endocrine drugs

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Can you name the Endocrinology histology?

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IndicationDrugContraindications, side effects and note
Obesity (against appetite)Depression, anxiety, nausea
Obesity (against fat absorption)Steatorrhea
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
HyperthyroidismDelayed hypothyroidism
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Kidney stones, idiopathic hypercalciuriaHypercalcemia
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
Cortisol suppression tests, psoriasis, eczemaThinning skin
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
T1DM and T2DMWeight gain, hypoglycemia
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
IndicationDrugContraindications, side effects and note
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
Paget's diseaseA cytotoxic antibiotic
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
Osteoporosis (for increasing bone mass)Very expensive
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
PCOS (hirsutism)Hyperkalemia
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash

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