Endocrine drugs

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Can you name the Endocrinology histology?

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IndicationDrugContraindications, side effects and note
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
PCOS (hirsutism)Hyperkalemia
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
Obesity (against appetite)Depression, anxiety, nausea
Kidney stones, idiopathic hypercalciuriaHypercalcemia
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
Osteoporosis (for increasing bone mass)Very expensive
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
IndicationDrugContraindications, side effects and note
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
Obesity (against fat absorption)Steatorrhea
T1DM and T2DMWeight gain, hypoglycemia
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Paget's diseaseA cytotoxic antibiotic
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
HyperthyroidismDelayed hypothyroidism
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
Cortisol suppression tests, psoriasis, eczemaThinning skin
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
T2DM (by inhibiting carb absorption)Flatulence, diarrhea

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Created Nov 7, 2011ReportNominate
Tags:drug, effect, endocrine, indication, note, side