Endocrine drugs

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Can you name the Endocrinology histology?

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IndicationDrugContraindications, side effects and note
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
Osteoporosis (for increasing bone mass)Very expensive
Obesity (against fat absorption)Steatorrhea
Paget's diseaseA cytotoxic antibiotic
HyperthyroidismDelayed hypothyroidism
Obesity (against appetite)Depression, anxiety, nausea
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
T1DM and T2DMWeight gain, hypoglycemia
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
IndicationDrugContraindications, side effects and note
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
PCOS (hirsutism)Hyperkalemia
Cortisol suppression tests, psoriasis, eczemaThinning skin
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
Kidney stones, idiopathic hypercalciuriaHypercalcemia
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness

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Created Nov 7, 2011ReportNominate
Tags:drug, effect, endocrine, indication, note, side