Endocrine drugs

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Can you name the Endocrinology histology?

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IndicationDrugContraindications, side effects and note
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
Paget's diseaseA cytotoxic antibiotic
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
PCOS (hirsutism)Hyperkalemia
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
Obesity (against appetite)Depression, anxiety, nausea
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
Cortisol suppression tests, psoriasis, eczemaThinning skin
IndicationDrugContraindications, side effects and note
Obesity (against fat absorption)Steatorrhea
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
T1DM and T2DMWeight gain, hypoglycemia
Kidney stones, idiopathic hypercalciuriaHypercalcemia
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
HyperthyroidismDelayed hypothyroidism
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
Osteoporosis (for increasing bone mass)Very expensive

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Created Nov 7, 2011ReportNominate
Tags:drug, effect, endocrine, indication, note, side