Endocrine drugs

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Can you name the Endocrinology histology?

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IndicationDrugContraindications, side effects and note
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
Obesity (against appetite)Depression, anxiety, nausea
Cortisol suppression tests, psoriasis, eczemaThinning skin
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
Obesity (against fat absorption)Steatorrhea
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
Paget's diseaseA cytotoxic antibiotic
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
IndicationDrugContraindications, side effects and note
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
Osteoporosis (for increasing bone mass)Very expensive
T1DM and T2DMWeight gain, hypoglycemia
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
PCOS (hirsutism)Hyperkalemia
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
Kidney stones, idiopathic hypercalciuriaHypercalcemia
HyperthyroidismDelayed hypothyroidism
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin

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