Can you name the Endocrinology histology? by klamberry

Indication	Drug	Contraindications, side effects and note
PCOS (hirsutism, by blocking T to DHT conversion)		Impotence
Anything (adrenal crisis, chronic adrenal insufficiency)		Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
Hyperthyroidism (more potent, crosses placenta)		Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
T1DM (short acting)		Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
PCOS (hirsutism)		Hyperkalemia
Kidney stones, idiopathic hypercalciuria		Hypercalcemia
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosis		Hypocalcemia, kidney stones
T1DM (long acting)		Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
Osteoporosis, osteomalacia, rickets, hypoparathyroidism		Hypercalcemia, particularly dangerous in patients taking digoxin
T2DM (by blocking ATP-sensitive K channel)		Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
T2DM (by increasing insulin release)		Expensive, by injection, also decreases appetite, gastric motility
PCOS (hirsutism, by inhibiting binding of testosterone)		Liver toxicity, gynecomastia, erectile dysfunction
Hyperthyroidism		Delayed hypothyroidism
Hypoglycemia		Subcutaneous injection, can cause hyperglycemia
Hypoaldosteronism, chronic adrenal insufficiency		Hypokalemic alkalosis
T1DM and T2DM		Weight gain, hypoglycemia
PCOS (hirsutism, by inhibiting binding of testosterone)		Mild liver injury, GI
Precocious puberty		Headache, depression, insomnia, nausea and vomiting
Hyperparathyroidism, hypercalcemia		Inhibit PTH synthesis at lower concentrations of calcium
Obesity (against fat absorption)		Steatorrhea

Indication	Drug	Contraindications, side effects and note
Hyperthyroidism (less potent, does not cross placenta)		Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
T2DM (by inhibiting carb absorption)		Flatulence, diarrhea
Osteoporosis (for increasing bone mass)		Very expensive
T2DM (by blocking PPAR in adipocytes)		Weight gain, possible liver disease and cardiac failure, bladder cancer
T1DM (long acting)		Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
T1DM (intermediate acting)		Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
T2DM (by blocking ATP-sensitive K channel, weakly)		Weight gain, hypoglycemia, nausea, vomiting
Paget's disease, osteoporosis, hypercalcemia of malignancy		Gastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
T2DM (by reducing incretin degradation)		Oral administration, decreases appetite with less effect
Hypothyroidism		Warm moist skin, increased CO and pulse pressure, increased appetite, weakness
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)		Vasomotor flushing, visual blurring, ovary enlargement
Myxedema coma, preparing for iodine therapy		Warm moist skin, increased CO and pulse pressure, increased appetite, weakness
Hypothyroidism or hyperthyroidism		Hypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
Obesity (against appetite)		Depression, anxiety, nausea
Obesity (against appetite)		Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
T2DM (by activating AMPPK)		Lactic acidosis, anorexia, nausea, flatulence, diarrhea
Cortisol suppression tests, psoriasis, eczema		Thinning skin
Paget's disease		A cytotoxic antibiotic
Hyperaldosteronism (Conn's syndrome)		Hyperkalemia

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