Endocrine drugs

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Can you name the Endocrinology histology?

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Score 0/39 Timer 10:00
IndicationDrugContraindications, side effects and note
Osteoporosis (for increasing bone mass)Very expensive
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
HyperthyroidismDelayed hypothyroidism
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
Cortisol suppression tests, psoriasis, eczemaThinning skin
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
Obesity (against appetite)Depression, anxiety, nausea
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
PCOS (hirsutism)Hyperkalemia
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
Obesity (against fat absorption)Steatorrhea
Kidney stones, idiopathic hypercalciuriaHypercalcemia
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
IndicationDrugContraindications, side effects and note
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Paget's diseaseA cytotoxic antibiotic
T1DM and T2DMWeight gain, hypoglycemia
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones

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