Endocrine drugs

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Can you name the Endocrinology histology?

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Score 0/39 Timer 10:00
IndicationDrugContraindications, side effects and note
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Osteoporosis (for increasing bone mass)Very expensive
Paget's diseaseA cytotoxic antibiotic
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones
Obesity (against fat absorption)Steatorrhea
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
Obesity (against appetite)Depression, anxiety, nausea
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
Cortisol suppression tests, psoriasis, eczemaThinning skin
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
IndicationDrugContraindications, side effects and note
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
Kidney stones, idiopathic hypercalciuriaHypercalcemia
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
HyperthyroidismDelayed hypothyroidism
T1DM and T2DMWeight gain, hypoglycemia
PCOS (hirsutism)Hyperkalemia
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis

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