Science / Endocrine drugs

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Can you name the Endocrinology histology?

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IndicationDrugContraindications, side effects and note
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
Paget's diseaseA cytotoxic antibiotic
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
Cortisol suppression tests, psoriasis, eczemaThinning skin
T1DM and T2DMWeight gain, hypoglycemia
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
HyperthyroidismDelayed hypothyroidism
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
IndicationDrugContraindications, side effects and note
Kidney stones, idiopathic hypercalciuriaHypercalcemia
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
Osteoporosis (for increasing bone mass)Very expensive
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
Obesity (against fat absorption)Steatorrhea
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
PCOS (hirsutism)Hyperkalemia
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
Obesity (against appetite)Depression, anxiety, nausea

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