Endocrine drugs

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Can you name the Endocrinology histology?

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Score 0/39 Timer 10:00
IndicationDrugContraindications, side effects and note
HyperthyroidismDelayed hypothyroidism
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
Osteoporosis (for increasing bone mass)Very expensive
Obesity (against appetite)Depression, anxiety, nausea
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
IndicationDrugContraindications, side effects and note
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
PCOS (hirsutism)Hyperkalemia
Paget's diseaseA cytotoxic antibiotic
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
T1DM and T2DMWeight gain, hypoglycemia
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
Cortisol suppression tests, psoriasis, eczemaThinning skin
Kidney stones, idiopathic hypercalciuriaHypercalcemia
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
Obesity (against fat absorption)Steatorrhea
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash

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