Endocrine drugs

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Can you name the Endocrinology histology?

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IndicationDrugContraindications, side effects and note
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
Osteoporosis (for increasing bone mass)Very expensive
PCOS (hirsutism)Hyperkalemia
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
Paget's diseaseA cytotoxic antibiotic
Obesity (against appetite)Depression, anxiety, nausea
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
Kidney stones, idiopathic hypercalciuriaHypercalcemia
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
Obesity (against fat absorption)Steatorrhea
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
HyperthyroidismDelayed hypothyroidism
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
IndicationDrugContraindications, side effects and note
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
T1DM and T2DMWeight gain, hypoglycemia
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
Cortisol suppression tests, psoriasis, eczemaThinning skin
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones

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