Endocrine drugs

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Can you name the Endocrinology histology?

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IndicationDrugContraindications, side effects and note
Osteoporosis (for increasing bone mass)Very expensive
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
PCOS (hirsutism)Hyperkalemia
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
T1DM and T2DMWeight gain, hypoglycemia
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
Kidney stones, idiopathic hypercalciuriaHypercalcemia
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
Cortisol suppression tests, psoriasis, eczemaThinning skin
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
Obesity (against fat absorption)Steatorrhea
Paget's diseaseA cytotoxic antibiotic
IndicationDrugContraindications, side effects and note
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
Obesity (against appetite)Depression, anxiety, nausea
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
HyperthyroidismDelayed hypothyroidism

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Created Nov 7, 2011ReportNominate
Tags:drug, effect, endocrine, indication, note, side