Endocrine drugs

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Can you name the Endocrinology histology?

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IndicationDrugContraindications, side effects and note
PCOS (hirsutism)Hyperkalemia
Hyperthyroidism (less potent, does not cross placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
PCOS (hirsutism, by inhibiting binding of testosterone)Mild liver injury, GI
T1DM (long acting) Hypoglycemia, onset: 1hr, peak: 6h, lasts: 18h
PCOS (for increasing fertility, via blocking estrogen inhibition of hypothalamus)Vasomotor flushing, visual blurring, ovary enlargement
T2DM (by blocking ATP-sensitive K channel)Weight gain, hypoglycemia, nausea, vomiting, alcohol-induced flushing
Osteoporosis (for increasing bone mass)Very expensive
Myxedema coma, preparing for iodine therapyWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
HypoglycemiaSubcutaneous injection, can cause hyperglycemia
T2DM (by inhibiting carb absorption)Flatulence, diarrhea
Paget's diseaseA cytotoxic antibiotic
T2DM (by blocking ATP-sensitive K channel, weakly)Weight gain, hypoglycemia, nausea, vomiting
Kidney stones, idiopathic hypercalciuriaHypercalcemia
Obesity (against appetite)Increased heart rate, hypertension, sympathetic activation (dry mouth, constipation, nausea)
PCOS (hirsutism, by blocking T to DHT conversion)Impotence
Hypoaldosteronism, chronic adrenal insufficiencyHypokalemic alkalosis
Hyperthyroidism (more potent, crosses placenta)Cold dry skin, decreased pulse pressure, bradycardia, decreased appetite, fatigue, fever, rashes, jaundice, hepatitis, agranulocytosis
T1DM and T2DMWeight gain, hypoglycemia
Paget's disease, hyperparathyroidism, idiopathic juvenile hypercalcemia, vitamin D toxicosis, osteoporosisHypocalcemia, kidney stones
Obesity (against appetite)Depression, anxiety, nausea
IndicationDrugContraindications, side effects and note
Hypothyroidism or hyperthyroidismHypothyroidism (via Wolff-Chaikoff effect) or hyperthyroidism, hyperthyroidism if used for >8 weeks (Jod Basedow phenomenon)
T2DM (by reducing incretin degradation)Oral administration, decreases appetite with less effect
Obesity (against fat absorption)Steatorrhea
PCOS (hirsutism, by inhibiting binding of testosterone)Liver toxicity, gynecomastia, erectile dysfunction
Hyperparathyroidism, hypercalcemiaInhibit PTH synthesis at lower concentrations of calcium
Cortisol suppression tests, psoriasis, eczemaThinning skin
HypothyroidismWarm moist skin, increased CO and pulse pressure, increased appetite, weakness
Precocious pubertyHeadache, depression, insomnia, nausea and vomiting
Hyperaldosteronism (Conn's syndrome)Hyperkalemia
T1DM (intermediate acting) Hypoglycemia, onset: 30 min, peak: 2h, lasts: 8h
T1DM (short acting) Hypoglycemia, onset: 15 min, peak: 1h, lasts: 4h
T2DM (by blocking PPAR in adipocytes)Weight gain, possible liver disease and cardiac failure, bladder cancer
Paget's disease, osteoporosis, hypercalcemia of malignancyGastric irritation (abdo pain, diarrhea, loss of taste), bone pain, headache, rash
T1DM (long acting) Hypoglycemia, onset: 4hr, peak: none, lasts: 18h
HyperthyroidismDelayed hypothyroidism
T2DM (by increasing insulin release)Expensive, by injection, also decreases appetite, gastric motility
Osteoporosis, osteomalacia, rickets, hypoparathyroidismHypercalcemia, particularly dangerous in patients taking digoxin
Anything (adrenal crisis, chronic adrenal insufficiency)Cushingoid syndrome, edema, hypokalemic alkalosis, myopathy, induced ACTH insufficiency, reduced intestinal absorption of calcium
T2DM (by activating AMPPK)Lactic acidosis, anorexia, nausea, flatulence, diarrhea

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Created Nov 7, 2011ReportNominate
Tags:drug, effect, endocrine, indication, note, side