Goljan 5 of X: Autoimmune/neoplastic Dz marker

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Can you name the Goljan 5 of X: Disease markers and genes

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Rosenthal fibers
N-MYC implicated in what cancer
Anti-histone antibodies
Thorotrast, arsenic, polyvinyl chloride
Growth factor affected by osteosarcoma
Anti-giladin IgA
Mutated in familial adenomatous polyposis
Anti-desmoglein antibodies
Anti-Yo, Anti-P|Q, Anti-Hu
Inversion c.16
AD mutation in APC gene
Anti-ACh receptor antibodies
Anti-IgG antibodies
Pleomorphic astrocytes with brisk activity and necrosis
DCC mutation
Auto-antiobdy seen in seen in PBC
Auto-antiobdy seen in rheumatoid arthritis
Anti-thyroglobulin antibodies
NSE, Chromogranin, Synaptophysin, S100 (+)
LDH tumor marker
Anti-insulin antibodies
Anti-SS-A (Ro) antibodies
t(8;21)
Gene is involved in t(11;14)
BRAF V600E
Elevated bombesin
Causes centrilobular necrosis and fatty change of the liver
Auto-antiobdy seen in Churg-Strauss syndrome
Anti-tissue transglutiminase IgA
PML/RARa gene created by
HPV viral protein E7 target
CD10 is a positive indicator in...
Auto-antiobdy seen in drug-induced lupus
Anti-glutamate decarboxylase antibodies
c-Myc activating cancer leads to EWSFL1 over-production
Anti-proteinase 3 antibodies
CA 15-3 tumor marker
Gene mutated in NF2
Auto-antiobdy seen in mixed connective tissue disease
HintAnswer
Anti-parietal cell antibodies
Anti-intrinsic factor antibodies
What is translocation of mantle cell lymphoma?
Homer-wright rosettes
AD mutation in MLH1/MSH2
Anti-SS-B (La) antibodies
Auto-antibody seen in Wegener's granulomatosis
Auto-antiobdy seen in autoimmune hepatitis
Anti-smooth muscle antibodies
Anti-dsDNA antibodies
AFP tumor marker
HPV viral protein E6 target
Auto-antiobdy seen in CREST syndrome
Cystic brain tumor with granular eosinophilic bodies
Complement deficiency + S. pneumo septicemia + lupus-like syndrome
Anti-voltage-gated Ca2+ channel antibodies
t(11;14)
Pseudorosettes with GFAP positive processes
Anti-Sm antibodies
BCR-ABL fusion gene
Cells that stain (+) for synaptophysin
t(8;14) affects what gene
MCC1 complement deficiency
C-kit
CA 19-9 tumor marker
Anti-U1 RNP antibodies
Gene mutated in MEN 2a/2b
Anti-TSH receptor antibodies
14-3-3
C-MYC implicated in what cancer
Cause of liver angiosarcoma
Spindle cells with hair-like glial processes
AD mutation of NF1
Ki67 fraction >99%
CALLA is a positive indicator in...
Anti-LKM antibodies
Inheritance of hereditary angioedema
Hypocretin-1
Anti-GBM antibodies
HintAnswer
Mutated in Li-Fraumani syndrome
t(9;22)
Anti-microsomal antibodies
Anti-centormere antibodies
CEA tumor marker
t(15;17)
Cancer of CyclinD dysregulation
Defect in decay accelerating factor (DAF)
Anti-islet cell antibodies
Auto-antibody seen in microscopic polyangiitis
Anti-nuclear antibodies
Anti-mitochondrial antibodies
Gene involved in t(14;18)
Tumor marker for neuroblastoma
Anti-thyroperoxidase antibodies
t(14;18)
Receptor targeted by tratuzumab
Anti-ribonucleoprotein antibodies
Anti-endomysial IgA
High urinary HVA/VMA + N-Myc
Missing enzyme to degrade C3 and C4 convertase on RBCs
DPC mutation
Anti-MPO antibodies
Elevated tartrate-resistant acid phosphatase
ERB-B2 gene
Anti-SCL 70 antibodies
t(8;14)
Anti-Jo-1 antibodies
HVA in urine
AD mutation in p53 gene
Analine dyes
S-100 tumor marker
t(11;22)
Auto-antiobdy seen in Goodpasture syndrome
Anti-DNA topoisomerase 1 antibodies
Auto-antiobdy seen in Grave's disease
CA 125 tumor marker
Deficiency of C1 esterase inhibitor
Auto-antiobdy seen in polymyositis

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