Science / Goljan 5 of X: Autoimmune/neoplastic Dz marker

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Can you name the Goljan 5 of X: Disease markers and genes

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N-MYC implicated in what cancer
Anti-dsDNA antibodies
DPC mutation
Thorotrast, arsenic, polyvinyl chloride
PML/RARa gene created by
Anti-MPO antibodies
Auto-antiobdy seen in polymyositis
CALLA is a positive indicator in...
Auto-antiobdy seen in Goodpasture syndrome
Ki67 fraction >99%
HPV viral protein E6 target
Anti-thyroperoxidase antibodies
Anti-IgG antibodies
Anti-U1 RNP antibodies
HPV viral protein E7 target
Mutated in familial adenomatous polyposis
NSE, Chromogranin, Synaptophysin, S100 (+)
CD10 is a positive indicator in...
Auto-antibody seen in microscopic polyangiitis
AD mutation in MLH1/MSH2
AD mutation in p53 gene
Elevated tartrate-resistant acid phosphatase
BCR-ABL fusion gene
ERB-B2 gene
Auto-antiobdy seen in rheumatoid arthritis
Anti-smooth muscle antibodies
CA 125 tumor marker
Anti-histone antibodies
Anti-TSH receptor antibodies
Anti-glutamate decarboxylase antibodies
t(8;14) affects what gene
CEA tumor marker
Receptor targeted by tratuzumab
AFP tumor marker
Anti-SS-A (Ro) antibodies
Anti-tissue transglutiminase IgA
Auto-antiobdy seen in Grave's disease
Anti-GBM antibodies
Anti-ACh receptor antibodies
Anti-proteinase 3 antibodies
DCC mutation
Gene is involved in t(11;14)
Analine dyes
Homer-wright rosettes
Anti-DNA topoisomerase 1 antibodies
Auto-antiobdy seen in CREST syndrome
What is translocation of mantle cell lymphoma?
Anti-giladin IgA
Tumor marker for neuroblastoma
Anti-microsomal antibodies
Anti-thyroglobulin antibodies
Pseudorosettes with GFAP positive processes
HVA in urine
c-Myc activating cancer leads to EWSFL1 over-production
CA 15-3 tumor marker
Spindle cells with hair-like glial processes
Anti-Yo, Anti-P|Q, Anti-Hu
CA 19-9 tumor marker
High urinary HVA/VMA + N-Myc
Auto-antibody seen in Wegener's granulomatosis
Cystic brain tumor with granular eosinophilic bodies
Anti-desmoglein antibodies
Anti-centormere antibodies
Rosenthal fibers
C-MYC implicated in what cancer
Anti-insulin antibodies
Anti-Sm antibodies
Anti-intrinsic factor antibodies
Complement deficiency + S. pneumo septicemia + lupus-like syndrome
Anti-endomysial IgA
Pleomorphic astrocytes with brisk activity and necrosis
Gene involved in t(14;18)
MCC1 complement deficiency
Elevated bombesin
Gene mutated in NF2
S-100 tumor marker
Cells that stain (+) for synaptophysin
Anti-nuclear antibodies
Deficiency of C1 esterase inhibitor
Anti-parietal cell antibodies
Anti-LKM antibodies
AD mutation in APC gene
Causes centrilobular necrosis and fatty change of the liver
Anti-SCL 70 antibodies
Mutated in Li-Fraumani syndrome
Missing enzyme to degrade C3 and C4 convertase on RBCs
Anti-SS-B (La) antibodies
Auto-antiobdy seen in autoimmune hepatitis
Gene mutated in MEN 2a/2b
Anti-Jo-1 antibodies
Cause of liver angiosarcoma
Anti-voltage-gated Ca2+ channel antibodies
Cancer of CyclinD dysregulation
Inheritance of hereditary angioedema
Auto-antiobdy seen in seen in PBC
Anti-islet cell antibodies
Anti-ribonucleoprotein antibodies
Auto-antiobdy seen in drug-induced lupus
Defect in decay accelerating factor (DAF)
Anti-mitochondrial antibodies
AD mutation of NF1
LDH tumor marker
Inversion c.16
Growth factor affected by osteosarcoma
Auto-antiobdy seen in mixed connective tissue disease
Auto-antiobdy seen in Churg-Strauss syndrome

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