Goljan 5 of X: Autoimmune/neoplastic Dz marker

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Can you name the Goljan 5 of X: Disease markers and genes

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Gene mutated in MEN 2a/2b
What is translocation of mantle cell lymphoma?
Anti-glutamate decarboxylase antibodies
t(8;21)
Mutated in Li-Fraumani syndrome
Causes centrilobular necrosis and fatty change of the liver
Anti-histone antibodies
Cells that stain (+) for synaptophysin
CEA tumor marker
Anti-TSH receptor antibodies
High urinary HVA/VMA + N-Myc
N-MYC implicated in what cancer
Anti-endomysial IgA
Auto-antiobdy seen in polymyositis
Auto-antiobdy seen in seen in PBC
Anti-tissue transglutiminase IgA
DPC mutation
Auto-antibody seen in microscopic polyangiitis
t(8;14) affects what gene
Thorotrast, arsenic, polyvinyl chloride
Gene mutated in NF2
Anti-centormere antibodies
Auto-antiobdy seen in Churg-Strauss syndrome
Rosenthal fibers
Anti-nuclear antibodies
Anti-proteinase 3 antibodies
Anti-microsomal antibodies
Analine dyes
PML/RARa gene created by
Anti-intrinsic factor antibodies
Mutated in familial adenomatous polyposis
Auto-antiobdy seen in autoimmune hepatitis
Ki67 fraction >99%
Pseudorosettes with GFAP positive processes
ERB-B2 gene
Anti-U1 RNP antibodies
Homer-wright rosettes
Deficiency of C1 esterase inhibitor
AD mutation in p53 gene
HintAnswer
Anti-smooth muscle antibodies
Auto-antiobdy seen in mixed connective tissue disease
S-100 tumor marker
Auto-antiobdy seen in Grave's disease
Anti-thyroglobulin antibodies
t(11;22)
Spindle cells with hair-like glial processes
Anti-mitochondrial antibodies
t(11;14)
NSE, Chromogranin, Synaptophysin, S100 (+)
Defect in decay accelerating factor (DAF)
Anti-IgG antibodies
Anti-LKM antibodies
Elevated tartrate-resistant acid phosphatase
Elevated bombesin
AD mutation in MLH1/MSH2
Auto-antiobdy seen in CREST syndrome
Cancer of CyclinD dysregulation
Anti-giladin IgA
Anti-dsDNA antibodies
Anti-insulin antibodies
Inversion c.16
Anti-MPO antibodies
Missing enzyme to degrade C3 and C4 convertase on RBCs
Auto-antibody seen in Wegener's granulomatosis
Tumor marker for neuroblastoma
t(15;17)
BRAF V600E
Anti-DNA topoisomerase 1 antibodies
Anti-Jo-1 antibodies
Complement deficiency + S. pneumo septicemia + lupus-like syndrome
BCR-ABL fusion gene
Anti-Yo, Anti-P|Q, Anti-Hu
Pleomorphic astrocytes with brisk activity and necrosis
HPV viral protein E6 target
C-MYC implicated in what cancer
AFP tumor marker
Anti-ribonucleoprotein antibodies
AD mutation of NF1
HintAnswer
LDH tumor marker
Auto-antiobdy seen in drug-induced lupus
DCC mutation
Cystic brain tumor with granular eosinophilic bodies
Anti-thyroperoxidase antibodies
t(8;14)
HPV viral protein E7 target
Anti-ACh receptor antibodies
CD10 is a positive indicator in...
Anti-desmoglein antibodies
Anti-SS-B (La) antibodies
Anti-parietal cell antibodies
Anti-SCL 70 antibodies
Auto-antiobdy seen in rheumatoid arthritis
Anti-islet cell antibodies
CA 125 tumor marker
CA 15-3 tumor marker
Hypocretin-1
AD mutation in APC gene
Anti-GBM antibodies
CALLA is a positive indicator in...
CA 19-9 tumor marker
Gene involved in t(14;18)
HVA in urine
Growth factor affected by osteosarcoma
C-kit
t(9;22)
Anti-Sm antibodies
Cause of liver angiosarcoma
c-Myc activating cancer leads to EWSFL1 over-production
t(14;18)
Gene is involved in t(11;14)
Anti-SS-A (Ro) antibodies
Anti-voltage-gated Ca2+ channel antibodies
Receptor targeted by tratuzumab
Auto-antiobdy seen in Goodpasture syndrome
Inheritance of hereditary angioedema
MCC1 complement deficiency
14-3-3

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