Goljan 5 of X: Autoimmune/neoplastic Dz marker

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Can you name the Goljan 5 of X: Disease markers and genes

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HintAnswer
S-100 tumor marker
Anti-DNA topoisomerase 1 antibodies
t(8;14) affects what gene
Auto-antibody seen in microscopic polyangiitis
Mutated in familial adenomatous polyposis
DPC mutation
Auto-antiobdy seen in Churg-Strauss syndrome
Anti-endomysial IgA
Anti-glutamate decarboxylase antibodies
Analine dyes
Auto-antiobdy seen in autoimmune hepatitis
Anti-giladin IgA
BCR-ABL fusion gene
Gene is involved in t(11;14)
Cells that stain (+) for synaptophysin
Anti-thyroperoxidase antibodies
Anti-LKM antibodies
Cystic brain tumor with granular eosinophilic bodies
Cause of liver angiosarcoma
Anti-microsomal antibodies
Anti-Sm antibodies
CA 125 tumor marker
Gene mutated in NF2
t(15;17)
Anti-IgG antibodies
Anti-parietal cell antibodies
MCC1 complement deficiency
Auto-antiobdy seen in drug-induced lupus
Homer-wright rosettes
Anti-thyroglobulin antibodies
c-Myc activating cancer leads to EWSFL1 over-production
Pleomorphic astrocytes with brisk activity and necrosis
C-MYC implicated in what cancer
ERB-B2 gene
t(11;14)
Complement deficiency + S. pneumo septicemia + lupus-like syndrome
CD10 is a positive indicator in...
Elevated tartrate-resistant acid phosphatase
Gene involved in t(14;18)
HintAnswer
Anti-SS-B (La) antibodies
Pseudorosettes with GFAP positive processes
Anti-centormere antibodies
DCC mutation
Auto-antiobdy seen in mixed connective tissue disease
Hypocretin-1
Defect in decay accelerating factor (DAF)
AD mutation in APC gene
Deficiency of C1 esterase inhibitor
Anti-histone antibodies
t(14;18)
AD mutation in p53 gene
AFP tumor marker
Rosenthal fibers
Spindle cells with hair-like glial processes
BRAF V600E
Receptor targeted by tratuzumab
N-MYC implicated in what cancer
Anti-voltage-gated Ca2+ channel antibodies
t(8;14)
Anti-islet cell antibodies
Ki67 fraction >99%
Auto-antiobdy seen in polymyositis
Tumor marker for neuroblastoma
AD mutation of NF1
Anti-proteinase 3 antibodies
Anti-TSH receptor antibodies
Growth factor affected by osteosarcoma
Anti-tissue transglutiminase IgA
Anti-mitochondrial antibodies
Anti-U1 RNP antibodies
Anti-Jo-1 antibodies
Anti-nuclear antibodies
Inheritance of hereditary angioedema
Causes centrilobular necrosis and fatty change of the liver
Elevated bombesin
Cancer of CyclinD dysregulation
Mutated in Li-Fraumani syndrome
t(8;21)
HintAnswer
Anti-MPO antibodies
PML/RARa gene created by
Gene mutated in MEN 2a/2b
Anti-SCL 70 antibodies
CA 19-9 tumor marker
C-kit
Missing enzyme to degrade C3 and C4 convertase on RBCs
What is translocation of mantle cell lymphoma?
Anti-SS-A (Ro) antibodies
HPV viral protein E6 target
Anti-Yo, Anti-P|Q, Anti-Hu
Auto-antiobdy seen in rheumatoid arthritis
Thorotrast, arsenic, polyvinyl chloride
Anti-GBM antibodies
Auto-antiobdy seen in Goodpasture syndrome
Anti-smooth muscle antibodies
CA 15-3 tumor marker
Anti-insulin antibodies
Anti-intrinsic factor antibodies
Anti-ACh receptor antibodies
LDH tumor marker
HVA in urine
High urinary HVA/VMA + N-Myc
Auto-antibody seen in Wegener's granulomatosis
t(11;22)
Anti-ribonucleoprotein antibodies
Auto-antiobdy seen in CREST syndrome
HPV viral protein E7 target
Anti-dsDNA antibodies
Anti-desmoglein antibodies
Inversion c.16
14-3-3
t(9;22)
Auto-antiobdy seen in Grave's disease
CEA tumor marker
NSE, Chromogranin, Synaptophysin, S100 (+)
Auto-antiobdy seen in seen in PBC
CALLA is a positive indicator in...
AD mutation in MLH1/MSH2

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