Goljan 5 of X: Autoimmune/neoplastic Dz marker

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Can you name the Goljan 5 of X: Disease markers and genes

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NSE, Chromogranin, Synaptophysin, S100 (+)
Anti-Sm antibodies
Anti-proteinase 3 antibodies
Anti-LKM antibodies
Cause of liver angiosarcoma
Anti-TSH receptor antibodies
t(15;17)
N-MYC implicated in what cancer
AD mutation in p53 gene
ERB-B2 gene
Gene mutated in MEN 2a/2b
Anti-desmoglein antibodies
What is translocation of mantle cell lymphoma?
Missing enzyme to degrade C3 and C4 convertase on RBCs
Anti-glutamate decarboxylase antibodies
CEA tumor marker
BCR-ABL fusion gene
Anti-thyroglobulin antibodies
Elevated bombesin
Auto-antiobdy seen in autoimmune hepatitis
AD mutation in APC gene
HPV viral protein E6 target
PML/RARa gene created by
t(8;14) affects what gene
Anti-giladin IgA
Anti-Yo, Anti-P|Q, Anti-Hu
Anti-IgG antibodies
Complement deficiency + S. pneumo septicemia + lupus-like syndrome
Tumor marker for neuroblastoma
Homer-wright rosettes
t(14;18)
Anti-DNA topoisomerase 1 antibodies
Gene involved in t(14;18)
Cancer of CyclinD dysregulation
Causes centrilobular necrosis and fatty change of the liver
Auto-antibody seen in microscopic polyangiitis
Anti-dsDNA antibodies
DPC mutation
Auto-antiobdy seen in drug-induced lupus
HintAnswer
Anti-centormere antibodies
Spindle cells with hair-like glial processes
High urinary HVA/VMA + N-Myc
C-kit
Cystic brain tumor with granular eosinophilic bodies
Inversion c.16
S-100 tumor marker
Auto-antiobdy seen in rheumatoid arthritis
Auto-antiobdy seen in CREST syndrome
Anti-mitochondrial antibodies
Anti-U1 RNP antibodies
Ki67 fraction >99%
CALLA is a positive indicator in...
Auto-antiobdy seen in polymyositis
Anti-microsomal antibodies
Anti-MPO antibodies
Hypocretin-1
HVA in urine
AD mutation of NF1
Anti-histone antibodies
Analine dyes
t(9;22)
Anti-ACh receptor antibodies
LDH tumor marker
Anti-parietal cell antibodies
t(11;22)
Auto-antibody seen in Wegener's granulomatosis
BRAF V600E
Auto-antiobdy seen in Goodpasture syndrome
Cells that stain (+) for synaptophysin
Gene is involved in t(11;14)
Growth factor affected by osteosarcoma
Auto-antiobdy seen in mixed connective tissue disease
Auto-antiobdy seen in seen in PBC
Inheritance of hereditary angioedema
Anti-ribonucleoprotein antibodies
t(8;21)
Rosenthal fibers
14-3-3
HintAnswer
MCC1 complement deficiency
Anti-insulin antibodies
HPV viral protein E7 target
t(11;14)
CA 19-9 tumor marker
Thorotrast, arsenic, polyvinyl chloride
c-Myc activating cancer leads to EWSFL1 over-production
Auto-antiobdy seen in Grave's disease
Elevated tartrate-resistant acid phosphatase
Anti-smooth muscle antibodies
DCC mutation
Anti-islet cell antibodies
Anti-voltage-gated Ca2+ channel antibodies
CD10 is a positive indicator in...
CA 15-3 tumor marker
Pleomorphic astrocytes with brisk activity and necrosis
Anti-SS-A (Ro) antibodies
t(8;14)
CA 125 tumor marker
Anti-thyroperoxidase antibodies
AD mutation in MLH1/MSH2
Anti-SS-B (La) antibodies
Pseudorosettes with GFAP positive processes
Auto-antiobdy seen in Churg-Strauss syndrome
Anti-Jo-1 antibodies
AFP tumor marker
Mutated in Li-Fraumani syndrome
Anti-intrinsic factor antibodies
Anti-SCL 70 antibodies
Anti-endomysial IgA
Deficiency of C1 esterase inhibitor
Receptor targeted by tratuzumab
Anti-tissue transglutiminase IgA
Anti-nuclear antibodies
Gene mutated in NF2
Defect in decay accelerating factor (DAF)
Mutated in familial adenomatous polyposis
Anti-GBM antibodies
C-MYC implicated in what cancer

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