Goljan 5 of X: Autoimmune/neoplastic Dz marker

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Can you name the Goljan 5 of X: Disease markers and genes

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Anti-thyroglobulin antibodies
t(11;22)
Auto-antibody seen in Wegener's granulomatosis
Anti-IgG antibodies
t(9;22)
Cystic brain tumor with granular eosinophilic bodies
Mutated in Li-Fraumani syndrome
Anti-voltage-gated Ca2+ channel antibodies
Anti-Jo-1 antibodies
Anti-SS-B (La) antibodies
t(14;18)
Thorotrast, arsenic, polyvinyl chloride
t(8;14) affects what gene
S-100 tumor marker
Pleomorphic astrocytes with brisk activity and necrosis
Anti-smooth muscle antibodies
Anti-Yo, Anti-P|Q, Anti-Hu
Auto-antiobdy seen in mixed connective tissue disease
Auto-antiobdy seen in seen in PBC
Rosenthal fibers
Complement deficiency + S. pneumo septicemia + lupus-like syndrome
Anti-proteinase 3 antibodies
Ki67 fraction >99%
Anti-DNA topoisomerase 1 antibodies
Defect in decay accelerating factor (DAF)
High urinary HVA/VMA + N-Myc
Auto-antiobdy seen in drug-induced lupus
AD mutation in p53 gene
Hypocretin-1
AD mutation of NF1
Anti-LKM antibodies
Anti-parietal cell antibodies
Anti-centormere antibodies
Inversion c.16
Anti-endomysial IgA
AD mutation in MLH1/MSH2
Anti-thyroperoxidase antibodies
ERB-B2 gene
Anti-insulin antibodies
HintAnswer
DPC mutation
Anti-ribonucleoprotein antibodies
Growth factor affected by osteosarcoma
Cause of liver angiosarcoma
CA 19-9 tumor marker
Elevated tartrate-resistant acid phosphatase
Auto-antiobdy seen in rheumatoid arthritis
NSE, Chromogranin, Synaptophysin, S100 (+)
Anti-intrinsic factor antibodies
t(15;17)
Auto-antiobdy seen in Churg-Strauss syndrome
Anti-mitochondrial antibodies
N-MYC implicated in what cancer
Anti-SS-A (Ro) antibodies
Anti-MPO antibodies
Anti-giladin IgA
Cancer of CyclinD dysregulation
Auto-antiobdy seen in Grave's disease
Anti-U1 RNP antibodies
Spindle cells with hair-like glial processes
Anti-nuclear antibodies
Anti-GBM antibodies
CD10 is a positive indicator in...
Analine dyes
PML/RARa gene created by
BRAF V600E
AFP tumor marker
Auto-antiobdy seen in autoimmune hepatitis
Anti-glutamate decarboxylase antibodies
Auto-antibody seen in microscopic polyangiitis
HPV viral protein E6 target
Gene is involved in t(11;14)
Gene mutated in NF2
Anti-ACh receptor antibodies
Tumor marker for neuroblastoma
LDH tumor marker
Elevated bombesin
Missing enzyme to degrade C3 and C4 convertase on RBCs
Anti-dsDNA antibodies
HintAnswer
Receptor targeted by tratuzumab
Anti-Sm antibodies
14-3-3
t(11;14)
CA 15-3 tumor marker
HPV viral protein E7 target
Gene involved in t(14;18)
MCC1 complement deficiency
Anti-histone antibodies
Auto-antiobdy seen in CREST syndrome
DCC mutation
t(8;21)
Anti-microsomal antibodies
Gene mutated in MEN 2a/2b
Auto-antiobdy seen in polymyositis
Cells that stain (+) for synaptophysin
Mutated in familial adenomatous polyposis
C-MYC implicated in what cancer
CALLA is a positive indicator in...
CEA tumor marker
t(8;14)
AD mutation in APC gene
c-Myc activating cancer leads to EWSFL1 over-production
Anti-desmoglein antibodies
Deficiency of C1 esterase inhibitor
Homer-wright rosettes
HVA in urine
Anti-TSH receptor antibodies
Pseudorosettes with GFAP positive processes
BCR-ABL fusion gene
C-kit
Causes centrilobular necrosis and fatty change of the liver
Anti-SCL 70 antibodies
What is translocation of mantle cell lymphoma?
Inheritance of hereditary angioedema
Auto-antiobdy seen in Goodpasture syndrome
CA 125 tumor marker
Anti-tissue transglutiminase IgA
Anti-islet cell antibodies

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