Science / Goljan 5 of X: Autoimmune/neoplastic Dz marker

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Can you name the Goljan 5 of X: Disease markers and genes

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Auto-antibody seen in microscopic polyangiitis
Missing enzyme to degrade C3 and C4 convertase on RBCs
Anti-GBM antibodies
Thorotrast, arsenic, polyvinyl chloride
Receptor targeted by tratuzumab
Growth factor affected by osteosarcoma
Complement deficiency + S. pneumo septicemia + lupus-like syndrome
Mutated in Li-Fraumani syndrome
Anti-SS-A (Ro) antibodies
AD mutation in MLH1/MSH2
Auto-antiobdy seen in mixed connective tissue disease
Anti-giladin IgA
Auto-antiobdy seen in rheumatoid arthritis
Ki67 fraction >99%
Auto-antiobdy seen in Grave's disease
Cells that stain (+) for synaptophysin
Anti-TSH receptor antibodies
Gene mutated in NF2
Pleomorphic astrocytes with brisk activity and necrosis
Auto-antiobdy seen in Churg-Strauss syndrome
NSE, Chromogranin, Synaptophysin, S100 (+)
CA 15-3 tumor marker
HPV viral protein E6 target
Anti-islet cell antibodies
Tumor marker for neuroblastoma
Anti-SS-B (La) antibodies
CALLA is a positive indicator in...
c-Myc activating cancer leads to EWSFL1 over-production
AFP tumor marker
Anti-Jo-1 antibodies
High urinary HVA/VMA + N-Myc
Auto-antiobdy seen in drug-induced lupus
AD mutation in APC gene
Anti-tissue transglutiminase IgA
Anti-DNA topoisomerase 1 antibodies
DCC mutation
C-MYC implicated in what cancer
Anti-nuclear antibodies
Cause of liver angiosarcoma
BCR-ABL fusion gene
Anti-desmoglein antibodies
Anti-thyroperoxidase antibodies
Anti-ACh receptor antibodies
Inversion c.16
Cancer of CyclinD dysregulation
Anti-dsDNA antibodies
Anti-Sm antibodies
Gene involved in t(14;18)
Gene mutated in MEN 2a/2b
Anti-Yo, Anti-P|Q, Anti-Hu
Auto-antiobdy seen in CREST syndrome
t(8;14) affects what gene
Elevated bombesin
Defect in decay accelerating factor (DAF)
ERB-B2 gene
Anti-histone antibodies
Anti-smooth muscle antibodies
AD mutation in p53 gene
Anti-intrinsic factor antibodies
What is translocation of mantle cell lymphoma?
Causes centrilobular necrosis and fatty change of the liver
Anti-proteinase 3 antibodies
Elevated tartrate-resistant acid phosphatase
CD10 is a positive indicator in...
DPC mutation
HPV viral protein E7 target
Anti-U1 RNP antibodies
Anti-insulin antibodies
Anti-voltage-gated Ca2+ channel antibodies
CA 125 tumor marker
MCC1 complement deficiency
Inheritance of hereditary angioedema
S-100 tumor marker
HVA in urine
Anti-MPO antibodies
LDH tumor marker
Rosenthal fibers
N-MYC implicated in what cancer
Anti-centormere antibodies
Anti-microsomal antibodies
AD mutation of NF1
CEA tumor marker
Anti-ribonucleoprotein antibodies
PML/RARa gene created by
Anti-mitochondrial antibodies
Auto-antibody seen in Wegener's granulomatosis
Gene is involved in t(11;14)
Pseudorosettes with GFAP positive processes
Auto-antiobdy seen in Goodpasture syndrome
Anti-endomysial IgA
Anti-SCL 70 antibodies
Analine dyes
CA 19-9 tumor marker
Deficiency of C1 esterase inhibitor
Anti-LKM antibodies
Anti-glutamate decarboxylase antibodies
Auto-antiobdy seen in autoimmune hepatitis
Mutated in familial adenomatous polyposis
Cystic brain tumor with granular eosinophilic bodies
Anti-parietal cell antibodies
Anti-thyroglobulin antibodies
Auto-antiobdy seen in seen in PBC
Homer-wright rosettes
Anti-IgG antibodies
Auto-antiobdy seen in polymyositis
Spindle cells with hair-like glial processes

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