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Can you name the Biochem?

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Signs/SymptomsDeficiency OR DiseaseDisease: accumulated substance
hyperammonia, orotic aciduria and acidemia, low BUN
central and peripheral demyelination, ataxia, dementia
high glycogen in muscle, painful cramps, myoglobinuria
developmental delay, gargoylism, airway obstruction, corneal clouding, CAD, HSM
homocystinuria, MR, osteoporosis, marfanoid, lens subluxation, atherosclerosis
severe fasting hypoglycemia, very high glycogen in liver, high blood lactate, hepatomegaly
lack of melanin
mild fasting hypoglycemia, normal blood lactate, mild hepatomegaly
FTT, jaundice, HSM/cirrhosis, infantile cataracts, MR
mild, galactosemia, infantile cataracts
cardiomegaly, liver failure, MR, hypotonia
progressive neurodegeneration, HSM, cherry red spot on macula, foam cells
mild developmental delay, mild gargoylism, mild airway obstruction, aggressive behavior, no corneal clouding
Signs/SymptomsDeficiency OR DiseaseDisease: accumulated substance
MR, sz, fair skin, eczema, musty body odor, growth retardataion
dark connective tissue, black urine, arthralgia
severe CNS defects, MR, death, urine smells sweet, excess alpha keto acids in blood/urine
hypoglycemia, jaundice, cirrhosis, CKD, N/V
progressive neurodegeneration, muscle weakness, developmental delay, cherry red spot on macula, 'onion-skin' lysosomes, NO HSM
pellagra, tryptophan in urine
peripheral neuropathy, developmental delay, optic atrophy, hypertonia, irritability, globoid cells
peripheral neuropathy of hands/feet, angiokeratomas, cardiovascular/renal disease, corneal changes, GI symptoms
hemolysis when exposed to infection or oxidizing agent
cystinuria, staghorn calculi
HSM, aseptic necrosis of femur, bone crises, macrophages that look like crumpled tissue paper

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