Biochem

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Can you name the Biochem?

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Signs/SymptomsDeficiency OR DiseaseDisease: accumulated substance
progressive neurodegeneration, HSM, cherry red spot on macula, foam cells
mild developmental delay, mild gargoylism, mild airway obstruction, aggressive behavior, no corneal clouding
cystinuria, staghorn calculi
hyperammonia, orotic aciduria and acidemia, low BUN
progressive neurodegeneration, muscle weakness, developmental delay, cherry red spot on macula, 'onion-skin' lysosomes, NO HSM
MR, sz, fair skin, eczema, musty body odor, growth retardataion
high glycogen in muscle, painful cramps, myoglobinuria
severe fasting hypoglycemia, very high glycogen in liver, high blood lactate, hepatomegaly
cardiomegaly, liver failure, MR, hypotonia
mild fasting hypoglycemia, normal blood lactate, mild hepatomegaly
FTT, jaundice, HSM/cirrhosis, infantile cataracts, MR
lack of melanin
mild, galactosemia, infantile cataracts
Signs/SymptomsDeficiency OR DiseaseDisease: accumulated substance
hypoglycemia, jaundice, cirrhosis, CKD, N/V
peripheral neuropathy of hands/feet, angiokeratomas, cardiovascular/renal disease, corneal changes, GI symptoms
HSM, aseptic necrosis of femur, bone crises, macrophages that look like crumpled tissue paper
peripheral neuropathy, developmental delay, optic atrophy, hypertonia, irritability, globoid cells
fructosuria/asx
severe CNS defects, MR, death, urine smells sweet, excess alpha keto acids in blood/urine
hemolysis when exposed to infection or oxidizing agent
developmental delay, gargoylism, airway obstruction, corneal clouding, CAD, HSM
dark connective tissue, black urine, arthralgia
pellagra, tryptophan in urine
homocystinuria, MR, osteoporosis, marfanoid, lens subluxation, atherosclerosis
central and peripheral demyelination, ataxia, dementia

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